730 research outputs found
Postbuckling of a Circular Plate - Comparing Different Solutions
Azisymmetric problems have been often investigated in the past. Since the problem is one-dimensional, the boundary problem is suitable for analytical investigations and acts as a benchmark for numerical methods. The postbuckling of an elastic circular plate under azisymmetric loading is investigated. An analytical description is given. Solutions by means of the perturbation method and the finite element method (axisymmetric shell element) are introduced. Numerical results are presented
Remarks on Raasch’s Hook
Finite Element’s designers have always been seeking for benchmarks to judge the capability and potentiality of a numerical method. Considering shell elements many benchmark tests have been established over the years. The Raasch challenge problem, a clamped curved hook with a tip in-plane shear load, acts as a very interesting benchmark of shell elements. The structure consists of two cylindrical shells with different curvatures. In this paper the problem is also modelled as a curved beam with a rectangular cross-section. The beam model is investigated analytically. Thus an analytical expression for the tip deflection can be obtained. Further on numerical calculations with 4-node-shell elements based on a director theory are carried out and verify the elements applicability
Factorization for generic jet production
Factorization is the central ingredient in any theoretical prediction for
collider experiments. We introduce a factorization formalism that can be
applied to any desired observable, like event shapes or jet observables, for
any number of jets and a wide range of jet algorithms in leptonic or hadronic
collisions. This is achieved by using soft-collinear effective theory to prove
the formal factorization of a generic fully-differential cross section in terms
of a hard coefficient, and generic jet and soft functions. In this formalism,
whether a given observable factorizes in the usual sense, depends on whether it
is inclusive enough, so the jet functions can be calculated perturbatively. The
factorization formula for any such observable immediately follows from our
general result, including the precise definition of the jet and soft functions
appropriate for the observable in question. As examples of our formalism, we
work out several results in two-jet production for both e+e- and pp collisions.
For the latter, we also comment on how our formalism allows one to treat
underlying events and beam remnants.Comment: 33 pages, v2: minor typos corrected, journal versio
Selected vitamins and trace elements support immune function by strengthening epithelial barriers and cellular and humoral immune responses
Adequate intakes of micronutrients are required for the immune system to function efficiently. Micronutrient deficiency suppresses immunity by affecting innate, T cell mediated and adaptive antibody responses, leading to dysregulation of the balanced host response. This situation increases susceptibility to infections, with increased morbidity and mortality. In turn, infections aggravate micronutrient deficiencies by reducing nutrient intake, increasing losses, and interfering with utilization by altering metabolic pathways. Insufficient intake of micronutrients occurs in people with eating disorders, in smokers (active and passive), in individuals with chronic alcohol abuse, in certain diseases, during pregnancy and lactation, and in the elderly. This paper summarises the roles of selected vitamins and trace elements in immune function. Micronutrients contribute to the body's natural defences on three levels by supporting physical barriers (skin/mucosa), cellular immunity and antibody production. Vitamins A, C, E and the trace element zinc assist in enhancing the skin barrier function. The vitamins A, B6, B12, C, D, E and folic acid and the trace elements iron, zinc, copper and selenium work in synergy to support the protective activities of the immune cells. Finally, all these micronutrients, with the exception of vitamin C and iron, are essential for antibody production. Overall, inadequate intake and status of these vitamins and trace elements may lead to suppressed immunity, which predisposes to infections and aggravates malnutrition. Therefore, supplementation with these selected micronutrients can support the body's natural defence system by enhancing all three levels of immunit
Flux and field line conservation in 3--D nonideal MHD flows: Remarks about criteria for 3--D reconnection without magnetic neutral points
We make some remarks on reconnection in plasmas and want to present some
calculations related to the problem of finding velocity fields which conserve
magnetic flux or at least magnetic field lines. Hereby we start from views and
definitions of ideal and non-ideal flows on one hand, and of reconnective and
non-reconnective plasma dynamics on the other hand. Our considerations give
additional insights into the discussion on violations of the frozen--in field
concept which started recently with the papers by Baranov & Fahr (2003a;
2003b). We find a correlation between the nonidealness which is given by a
generalized form of the Ohm's law and a general transporting velocity, which is
field line conserving.Comment: 9 pages, 2 figures, submitted to Solar Physic
Non-global Structure of the O({\alpha}_s^2) Dijet Soft Function
High energy scattering processes involving jets generically involve matrix
elements of light- like Wilson lines, known as soft functions. These describe
the structure of soft contributions to observables and encode color and
kinematic correlations between jets. We compute the dijet soft function to
O({\alpha}_s^2) as a function of the two jet invariant masses, focusing on
terms not determined by its renormalization group evolution that have a
non-separable dependence on these masses. Our results include non-global single
and double logarithms, and analytic results for the full set of non-logarithmic
contributions as well. Using a recent result for the thrust constant, we
present the complete O({\alpha}_s^2) soft function for dijet production in both
position and momentum space.Comment: 55 pages, 8 figures. v2: extended discussion of double logs in the
hard regime. v3: minor typos corrected, version published in JHEP. v4: typos
in Eq. (3.33), (3.39), (3.43) corrected; this does not affect the main
result, numerical results, or conclusion
Stable propagation of an ordered array of cracks during directional drying
We study the appearance and evolution of an array of parallel cracks in a
thin slab of material that is directionally dried, and show that the cracks
penetrate the material uniformly if the drying front is sufficiently sharp. We
also show that cracks have a tendency to become evenly spaced during the
penetration. The typical distance between cracks is mainly governed by the
typical distance of the pattern at the surface, and it is not modified during
the penetration. Our results agree with recent experimental work, and can be
extended to three dimensions to describe the properties of columnar polygonal
patterns observed in some geological formations.Comment: 8 pages, 4 figures, to appear in PR
Recessive germline SDHA and SDHB mutations causing leukodystrophy and isolated mitochondrial complex II deficiency
Background Isolated complex II deficiency is a rare form of mitochondrial disease, accounting for approximately 2% of all respiratory chain deficiency diagnoses. The succinate dehydrogenase (SDH) genes (SDHA, SDHB, SDHC and SDHD) are autosomally-encoded and transcribe the conjugated heterotetramers of complex II via the action of two known assembly factors (SDHAF1 and SDHAF2). Only a handful of reports describe inherited SDH gene defects as a cause of paediatric mitochondrial disease, involving either SDHA (Leigh syndrome, cardiomyopathy) or SDHAF1 (infantile leukoencephalopathy). However, all four SDH genes, together with SDHAF2, have known tumour suppressor functions, with numerous germline and somatic mutations reported in association with hereditary cancer syndromes, including paraganglioma and pheochromocytoma.
Methods and results Here, we report the clinical and molecular investigations of two patients with histochemical and biochemical evidence of a severe, isolated complex II deficiency due to novel SDH gene mutations; the first patient presented with cardiomyopathy and leukodystrophy due to compound heterozygous p.Thr508Ile and p.Ser509Leu SDHA mutations, while the second patient presented with hypotonia and leukodystrophy with elevated brain succinate demonstrated by MR spectroscopy due to a novel, homozygous p.Asp48Val SDHB mutation. Western blotting and BN-PAGE studies confirmed decreased steady-state levels of the relevant SDH subunits and impairment of complex II assembly. Evidence from yeast complementation studies provided additional support for pathogenicity of the SDHB mutation.
Conclusions Our report represents the first example of SDHB mutation as a cause of inherited mitochondrial respiratory chain disease and extends the SDHA mutation spectrum in patients with isolated complex II deficiency
Jet Shapes and Jet Algorithms in SCET
Jet shapes are weighted sums over the four-momenta of the constituents of a
jet and reveal details of its internal structure, potentially allowing
discrimination of its partonic origin. In this work we make predictions for
quark and gluon jet shape distributions in N-jet final states in e+e-
collisions, defined with a cone or recombination algorithm, where we measure
some jet shape observable on a subset of these jets. Using the framework of
Soft-Collinear Effective Theory, we prove a factorization theorem for jet shape
distributions and demonstrate the consistent renormalization-group running of
the functions in the factorization theorem for any number of measured and
unmeasured jets, any number of quark and gluon jets, and any angular size R of
the jets, as long as R is much smaller than the angular separation between
jets. We calculate the jet and soft functions for angularity jet shapes \tau_a
to one-loop order (O(alpha_s)) and resum a subset of the large logarithms of
\tau_a needed for next-to-leading logarithmic (NLL) accuracy for both cone and
kT-type jets. We compare our predictions for the resummed \tau_a distribution
of a quark or a gluon jet produced in a 3-jet final state in e+e- annihilation
to the output of a Monte Carlo event generator and find that the dependence on
a and R is very similar.Comment: 62 pages plus 21 pages of Appendices, 13 figures, uses JHEP3.cls. v2:
corrections to finite parts of NLO jet functions, minor changes to plots,
clarified discussion of power corrections. v3: Journal version. Introductory
sections significantly reorganized for clarity, classification of logarithmic
accuracy clarified, results for non-Mercedes-Benz configurations adde
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