Risk faktors for fracture in middle-aged men and women

The number of fractures is increasing worldwide, and fractures frequently cause long-term disability, impaired quality of life and sometimes death. The Malmö Preventive Project, a population-based, prospective study, consisting of 22 444 men, mean age 44 and 10 902 women, mean age 50 years, provides data for evaluation of common public health conditions, such as fracture and diabetes. The follow-up was 19 and 15 years for men and women, respectively. Multiple risk factors for fracture were identified. In women, the most important risk factors were advancing age (relative risk RR 1.56, Confidence Interval 95% 1.45-1.68), previous fracture (RR 2.00, CI 95% 1.56-2.58) and diabetes (RR 1.87, CI 95% 1.26-2,79). In men, advancing age (RR 1.19, CI 95% 1.12-1.26), mental health problems (RR 1.92, CI 95% 1.47-2.51), increased levels of ? glutamyl transferase (RR 1.24, CI 95% 1.18-1.31) and diabetes (RR 2.38, CI 95% 1.65-3.42) were major risk contributors. Impaired glucose tolerance, evaluated through an oral glucose tolerance test, was in both genders associated with a substantially decreased risk of fractures, independent of age, BMI and smoking. This thesis has identified multiple risk factors for low-energy fracture, in both men and women, highlighting diabetes and mental health problems as major contributors in this age group. Current management strategies and therapeutic guidelines are not addressing a number of the identified risk factors. Subsequently, risk assessment can be substantially improved by adding these risk factors to intervention algorithms for middle-aged individuals

Viking '75 spacecraft design and test summary. Volume 1: Lander design

The Viking Mars program is summarized. The design of the Viking lander spacecraft is described

Viking '75 spacecraft design and test summary. Volume 3: Engineering test summary

The engineering test program for the lander and the orbiter are presented. The engineering program was developed to achieve confidence that the design was adequate to survive the expected mission environments and to accomplish the mission objective

NORDIC SKIING BIOMECHANICS AND PHYSIOLOGY

Cross-country skiing provides unique movement patterns and unique athletes for sport science research. The integration of physiology and biomechanics into research projects has provided insights into systemic solutions regarding high intensity, whole body exercise and how workload is distributed. Newly introduced ski sprint events have stimulated continued research to better understand performance and human capacity limitations

Completeness of case ascertainment and survival time error in English cancer registries: impact on 1-year survival estimates.

BACKGROUND: It has been suggested that cancer registries in England are too dependent on processing of information from death certificates, and consequently that cancer survival statistics reported for England are systematically biased and too low. METHODS: We have linked routine cancer registration records for colorectal, lung, and breast cancer patients with information from the Hospital Episode Statistics (HES) database for the period 2001-2007. Based on record linkage with the HES database, records missing in the cancer register were identified, and dates of diagnosis were revised. The effects of those revisions on the estimated survival time and proportion of patients surviving for 1 year or more were studied. Cases that were absent in the cancer register and present in the HES data with a relevant diagnosis code and a relevant surgery code were used to estimate (a) the completeness of the cancer register. Differences in survival times calculated from the two data sources were used to estimate (b) the possible extent of error in the recorded survival time in the cancer register. Finally, we combined (a) and (b) to estimate (c) the resulting differences in 1-year cumulative survival estimates. RESULTS: Completeness of case ascertainment in English cancer registries is high, around 98-99%. Using HES data added 1.9%, 0.4% and 2.0% to the number of colorectal, lung, and breast cancer registrations, respectively. Around 5-6% of rapidly fatal cancer registrations had survival time extended by more than a month, and almost 3% of rapidly fatal breast cancer records were extended by more than a year. The resulting impact on estimates of 1-year survival was small, amounting to 1.0, 0.8, and 0.4 percentage points for colorectal, lung, and breast cancer, respectively. INTERPRETATION: English cancer registration data cannot be dismissed as unfit for the purpose of cancer survival analysis. However, investigators should retain a critical attitude to data quality and sources of error in international cancer survival studies

Anisotropic Distribution of SDSS Satellite Galaxies: Planar (not Polar) Alignment

The distribution of satellite galaxies relative to isolated host galaxies in the Sloan Digital Sky Survey (SDSS) is investigated. Host-satellite systems are selected using three different methods, yielding samples of ~3300, ~1600, and \~950 satellites. In the plane of the sky, the distributions of all three samples show highly significant deviations from circular symmetry (> 99.99%, > 99.99%, and 99.79% confidence levels, respectively), and the degree of anisotropy is a strong function of the projected radius, r_p, at which the satellites are found. For r_p < 100 kpc, the SDSS satellites are aligned preferentially with the major axes of the hosts. This is in stark contrast to the Holmberg effect, in which satellites are aligned with the minor axes of host galaxies. The degree of anisotropy in the distribution of the SDSS satellites decreases with r_p and is consistent with an isotropic distribution at of order the 1-sigma level for 250 kpc < r_p < 500 kpc.Comment: ApJ Letters (in press); Discussion section substantially revised, SDSS DR3 included in the analysis, no significant changes to the result

Spectral Classification of Galaxies

We investigate the integrated spectra of a sample of 24 normal galaxies. A principal component analysis suggests that most of the variance present in the spectra is due to the differences in morphology of the galaxies in the sample. We show that spectroscopic parameters extracted from the spectra, like the amplitude of the 4000 \AA~ break or of the CN band, correlate well with Hubble types and are useful for quantitative classification.Comment: 7 pages uuencoded compressed PostScript file. To appear in Vistas in Astronomy, special issue on Artificial Neural Networks in Astronom

DIFFERENT TECHNICAL STRATEGIES AND BIOMECHANICAL ASPECTS OF DOUBLE POLlNG IN ELITE CROSS-COUNTRY SKIING

The purpose of this study was to analyse double poling (DP) regarding biomechanical performance determinants and different strategies. Eleven elite cross-country skiers performed DP at 85% of their maximal DP velocity (V85%) during roller skiing (treadmill; 1° inclination) while pole forces and selected joint angles were recorded. A 2D video evaluation categorised skiers into two different DP strategy groups. Strategy A group showed higher elbow (p < 0.01) and hip flexion angular velocities, smaller minimum elbow, knee and hip angles, higher peak pole force, shorter time to peak pole force and a longer relati.ve recovery time (p < 0.05), variables to which V85% was significantly correlated (p < 0.05). DP strategy A provides an effective model for technique and specific strength training while its physiological economy has to be further investigated