3,881 research outputs found
Kpc-scale Properties of Emission-line Galaxies
We perform a detailed study of the resolved properties of emission-line
galaxies at kpc-scale to investigate how small-scale and global properties of
galaxies are related. 119 galaxies with high-resolution Keck/DEIMOS spectra are
selected to cover a wide range in morphologies over the redshift range
0.2<z<1.3. Using the HST/ACS and HST/WFC3 imaging data taken as a part of the
CANDELS project, for each galaxy we perform SED fitting per resolution element,
producing resolved rest-frame U-V color, stellar mass, star formation rate, age
and extinction maps. We develop a technique to identify blue and red "regions"
within individual galaxies, using their rest-frame color maps. As expected, for
any given galaxy, the red regions are found to have higher stellar mass surface
densities and older ages compared to the blue regions. Furthermore, we quantify
the spatial distribution of red and blue regions with respect to both redshift
and stellar mass, finding that the stronger concentration of red regions toward
the centers of galaxies is not a significant function of either redshift or
stellar mass. We find that the "main sequence" of star forming galaxies exists
among both red and blue regions inside galaxies, with the median of blue
regions forming a tighter relation with a slope of 1.1+/-0.1 and a scatter of
~0.2 dex compared to red regions with a slope of 1.3+/-0.1 and a scatter of
~0.6 dex. The blue regions show higher specific Star Formation Rates (sSFR)
than their red counterparts with the sSFR decreasing since z~1, driver
primarily by the stellar mass surface densities rather than the SFRs at a giver
resolution element.Comment: 17 pages, 17 figures, Submitted to the Ap
Tissue microarray immunohistochemical detection of brachyury is not a prognostic indicator in chordoma.
Brachyury is a marker for notochord-derived tissues and neoplasms, such as chordoma. However, the prognostic relevance of brachyury expression in chordoma is still unknown. The improvement of tissue microarray technology has provided the opportunity to perform analyses of tumor tissues on a large scale in a uniform and consistent manner. This study was designed with the use of tissue microarray to determine the expression of brachyury. Brachyury expression in chordoma tissues from 78 chordoma patients was analyzed by immunohistochemical staining of tissue microarray. The clinicopathologic parameters, including gender, age, location of tumor and metastatic status were evaluated. Fifty-nine of 78 (75.64%) tumors showed nuclear staining for brachyury, and among them, 29 tumors (49.15%) showed 1+ (<30% positive cells) staining, 15 tumors (25.42%) had 2+ (31% to 60% positive cells) staining, and 15 tumors (25.42%) demonstrated 3+ (61% to 100% positive cells) staining. Brachyury nuclear staining was detected more frequently in sacral chordomas than in chordomas of the mobile spine. However, there was no significant relationship between brachyury expression and other clinical variables. By Kaplan-Meier analysis, brachyury expression failed to produce any significant relationship with the overall survival rate. In conclusion, brachyury expression is not a prognostic indicator in chordoma
On the equivalence of Eulerian and Lagrangian variables for the two-component Camassa-Holm system
The Camassa-Holm equation and its two-component Camassa-Holm system
generalization both experience wave breaking in finite time. To analyze this,
and to obtain solutions past wave breaking, it is common to reformulate the
original equation given in Eulerian coordinates, into a system of ordinary
differential equations in Lagrangian coordinates. It is of considerable
interest to study the stability of solutions and how this is manifested in
Eulerian and Lagrangian variables. We identify criteria of convergence, such
that convergence in Eulerian coordinates is equivalent to convergence in
Lagrangian coordinates. In addition, we show how one can approximate global
conservative solutions of the scalar Camassa-Holm equation by smooth solutions
of the two-component Camassa-Holm system that do not experience wave breaking
A Randomized, Double-Blinded, Phase II Trial of Gemcitabine and Nab-Paclitaxel Plus Apatorsen or Placebo in Patients with Metastatic Pancreatic Cancer: The RAINIER Trial.
Lessons learnedThe addition of the heat shock protein 27 (Hsp27)-targeting antisense oligonucleotide, apatorsen, to a standard first-line chemotherapy regimen did not result in improved survival in unselected patients with metastatic pancreatic cancer.Findings from this trial hint at the possible prognostic and predictive value of serum Hsp27 that may warrant further investigation.BackgroundThis randomized, double-blinded, phase II trial evaluated the efficacy of gemcitabine/nab-paclitaxel plus either apatorsen, an antisense oligonucleotide targeting heat shock protein 27 (Hsp27) mRNA, or placebo in patients with metastatic pancreatic cancer.MethodsPatients were randomized 1:1 to Arm A (gemcitabine/nab-paclitaxel plus apatorsen) or Arm B (gemcitabine/nab-paclitaxel plus placebo). Treatment was administered in 28-day cycles, with restaging every 2 cycles, until progression or intolerable toxicity. Serum Hsp27 levels were analyzed at baseline and on treatment. The primary endpoint was overall survival (OS).ResultsOne hundred thirty-two patients were enrolled, 66 per arm. Cytopenias and fatigue were the most frequent grade 3/4 treatment-related adverse events for both arms. Median progression-free survival (PFS) and OS were 2.7 and 5.3 months, respectively, for arm A, and 3.8 and 6.9 months, respectively, for arm B. Objective response rate was 18% for both arms. Patients with high serum level of Hsp27 represented a poor-prognosis subgroup who may have derived modest benefit from addition of apatorsen.ConclusionAddition of apatorsen to chemotherapy does not improve outcomes in unselected patients with metastatic pancreatic cancer in the first-line setting, although a trend toward prolonged PFS and OS in patients with high baseline serum Hsp27 suggests this therapy may warrant further evaluation in this subgroup
Comparison of mitotic cell death by chromosome fragmentation to premature chromosome condensation
Mitotic cell death is an important form of cell death, particularly in cancer. Chromosome fragmentation is a major form of mitotic cell death which is identifiable during common cytogenetic analysis by its unique phenotype of progressively degraded chromosomes. This morphology however, can appear similar to the morphology of premature chromosome condensation (PCC) and thus, PCC has been at times confused with chromosome fragmentation. In this analysis the phenomena of chromosome fragmentation and PCC are reviewed and their similarities and differences are discussed in order to facilitate differentiation of the similar morphologies. Furthermore, chromosome pulverization, which has been used almost synonymously with PCC, is re-examined. Interestingly, many past reports of chromosome pulverization are identified here as chromosome fragmentation and not PCC. These reports describe broad ranging mechanisms of pulverization induction and agree with recent evidence showing chromosome fragmentation is a cellular response to stress. Finally, biological aspects of chromosome fragmentation are discussed, including its application as one form of non-clonal chromosome aberration (NCCA), the driving force of cancer evolution
Understanding aneuploidy in cancer through the lens of system inheritance, fuzzy inheritance and emergence of new genome systems
Abstract
Background
In the past 15 years, impressive progress has been made to understand the molecular mechanism behind aneuploidy, largely due to the effort of using various -omics approaches to study model systems (e.g. yeast and mouse models) and patient samples, as well as the new realization that chromosome alteration-mediated genome instability plays the key role in cancer. As the molecular characterization of the causes and effects of aneuploidy progresses, the search for the general mechanism of how aneuploidy contributes to cancer becomes increasingly challenging: since aneuploidy can be linked to diverse molecular pathways (in regards to both cause and effect), the chances of it being cancerous is highly context-dependent, making it more difficult to study than individual molecular mechanisms. When so many genomic and environmental factors can be linked to aneuploidy, and most of them not commonly shared among patients, the practical value of characterizing additional genetic/epigenetic factors contributing to aneuploidy decreases.
Results
Based on the fact that cancer typically represents a complex adaptive system, where there is no linear relationship between lower-level agents (such as each individual gene mutation) and emergent properties (such as cancer phenotypes), we call for a new strategy based on the evolutionary mechanism of aneuploidy in cancer, rather than continuous analysis of various individual molecular mechanisms. To illustrate our viewpoint, we have briefly reviewed both the progress and challenges in this field, suggesting the incorporation of an evolutionary-based mechanism to unify diverse molecular mechanisms. To further clarify this rationale, we will discuss some key concepts of the genome theory of cancer evolution, including system inheritance, fuzzy inheritance, and cancer as a newly emergent cellular system.
Conclusion
Illustrating how aneuploidy impacts system inheritance, fuzzy inheritance and the emergence of new systems is of great importance. Such synthesis encourages efforts to apply the principles/approaches of complex adaptive systems to ultimately understand aneuploidy in cancer.https://deepblue.lib.umich.edu/bitstream/2027.42/143540/1/13039_2018_Article_376.pd
Jets as a Probe of Dense Matter at RHIC
Jet quenching in the matter created in high energy nucleus-nucleus collisions
provides a tomographic tool to probe the medium properties. Recent experimental
results on jet production at the Relativistic Heavy-Ion Collider (RHIC) are
reviewed. Jet properties in p+p and d+Au collisions have been measured,
establishing the baseline for studying jet modification in heavy-ion
collisions. Current progress on detailed studies of high transverse momentum
production in Au+Au collisions is discussed, with an emphasis on dihadron
correlation measurements.Comment: 8 pages, 9 figures. Plenary talk given at 17th International
Conference on Ultra Relativistic Nucleus-Nucleus Collisions (Quark Matter
2004), Oakland, California, 11-17 Jan 2004. Submitted to J.Phys.
Effect of local environment and stellar mass on galaxy quenching and morphology at
We study galactic star-formation activity as a function of environment and
stellar mass over 0.5<z<2.0 using the FourStar Galaxy Evolution (ZFOURGE)
survey. We estimate the galaxy environment using a Bayesian-motivated measure
of the distance to the third nearest neighbor for galaxies to the stellar mass
completeness of our survey, at z=1.3 (2.0). This
method, when applied to a mock catalog with the photometric-redshift precision
(), recovers galaxies in low- and high-density
environments accurately. We quantify the environmental quenching efficiency,
and show that at z> 0.5 it depends on galaxy stellar mass, demonstrating that
the effects of quenching related to (stellar) mass and environment are not
separable. In high-density environments, the mass and environmental quenching
efficiencies are comparable for massive galaxies (
10.5) at all redshifts. For lower mass galaxies (
10), the environmental quenching efficiency is very low at 1.5, but
increases rapidly with decreasing redshift. Environmental quenching can account
for nearly all quiescent lower mass galaxies ( 9-10),
which appear primarily at 1.0. The morphologies of lower mass
quiescent galaxies are inconsistent with those expected of recently quenched
star-forming galaxies. Some environmental process must transform the
morphologies on similar timescales as the environmental quenching itself. The
evolution of the environmental quenching favors models that combine gas
starvation (as galaxies become satellites) with gas exhaustion through
star-formation and outflows ("overconsumption"), and additional processes such
as galaxy interactions, tidal stripping and disk fading to account for the
morphological differences between the quiescent and star-forming galaxy
populations.Comment: 29 pages, 15 figure, accepted for publication in Ap
No More Active Galactic Nuclei in Clumpy Disks Than in Smooth Galaxies at z~2 in CANDELS / 3D-HST
We use CANDELS imaging, 3D-HST spectroscopy, and Chandra X-ray data to
investigate if active galactic nuclei (AGNs) are preferentially fueled by
violent disk instabilities funneling gas into galaxy centers at 1.3<z<2.4. We
select galaxies undergoing gravitational instabilities using the number of
clumps and degree of patchiness as proxies. The CANDELS visual classification
system is used to identify 44 clumpy disk galaxies, along with mass-matched
comparison samples of smooth and intermediate morphology galaxies. We note
that, despite being being mass-matched and having similar star formation rates,
the smoother galaxies tend to be smaller disks with more prominent bulges
compared to the clumpy galaxies. The lack of smooth extended disks is probably
a general feature of the z~2 galaxy population, and means we cannot directly
compare with the clumpy and smooth extended disks observed at lower redshift.
We find that z~2 clumpy galaxies have slightly enhanced AGN fractions selected
by integrated line ratios (in the mass-excitation method), but the spatially
resolved line ratios indicate this is likely due to extended phenomena rather
than nuclear AGNs. Meanwhile the X-ray data show that clumpy, smooth, and
intermediate galaxies have nearly indistinguishable AGN fractions derived from
both individual detections and stacked non-detections. The data demonstrate
that AGN fueling modes at z~1.85 - whether violent disk instabilities or
secular processes - are as efficient in smooth galaxies as they are in clumpy
galaxies.Comment: ApJ accepted. 17 pages, 17 figure
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