298 research outputs found
Electric-Field Gradient at Cd Impurities in In2o3. A FLAPW Study
We report an ab initio study of the electric-field gradient tensor (EFG) at
Cd impurities located at both inequivalent cationic sites in the semiconductor
In2O3. Calculations were performed with the FLAPW method, that allows us to
treat the electronic structure of the doped system and the atomic relaxations
introduced by the impurities in the host lattice in a fully self-consistent
way. From our results for the EFG (in excellent agreement with the
experiments), it is clear that the problem of the EFG at impurities in In2O3
cannot be described by the point-charge model and antishielding factors.Comment: 4 pages, 2 figures, and 2 table
The Physical Basis for Long-lived Electronic Coherence in Photosynthetic Light Harvesting Systems
The physical basis for observed long-lived electronic coherence in
photosynthetic light-harvesting systems is identified using an analytically
soluble model. Three physical features are found to be responsible for their
long coherence lifetimes: i) the small energy gap between excitonic states, ii)
the small ratio of the energy gap to the coupling between excitonic states, and
iii) the fact that the molecular characteristics place the system in an
effective low temperature regime, even at ambient conditions. Using this
approach, we obtain decoherence times for a dimer model with FMO parameters of
160 fs at 77 K and 80 fs at 277 K. As such, significant
oscillations are found to persist for 600 fs and 300 fs, respectively, in
accord with the experiment and with previous computations. Similar good
agreement is found for PC645 at room temperature, with oscillations persisting
for 400 fs. The analytic expressions obtained provide direct insight into the
parameter dependence of the decoherence time scales.Comment: 5 figures; J. Phys. Chem. Lett. (2011
Limited Macrophage Positional Dynamics in Progressing or Regressing Murine Atherosclerotic PlaquesBrief Report
Objective Macrophages play important roles in the pathogenesis of atherosclerosis, but their dynamics within plaques remain obscure. We aimed to quantify macrophage positional dynamics within progressing and regressing atherosclerotic plaques. Approach and Results In a stable intravital preparation, large asymmetrical foamy macrophages in the intima of carotid artery plaques were sessile, but smaller rounded cells nearer plaque margins, possibly newly recruited monocytes, mobilized laterally along plaque borders. Thus, to test macrophage dynamics in plaques over a longer period of time in progressing and regressing disease, we quantified displacement of nondegradable phagocytic particles within macrophages for up to 6 weeks. In progressing plaques, macrophage-associated particles appeared to mobilize to deeper layers in plaque, whereas in regressing plaques, the label was persistently located near the lumen. By measuring the distance of the particles from the floor of the plaque, we discovered that particles remained at the same distance from the floor regardless of plaque progression or regression. The apparent deeper penetration of labeled cells in progressing conditions could be attributed to monocyte recruitment that generated new superficial layers of macrophages over the labeled phagocytes. Conclusion: s Although there may be individual exceptions, as a population, newly differentiated macrophages fail to penetrate significantly deeper than the limited depth they reside on initial entry, regardless of plaque progression, or regression. These limited dynamics may prevent macrophages from escaping areas with unfavorable conditions (such as hypoxia) and pose a challenge for newly recruited macrophages to clear debris through efferocytosis deep within plaque
Am. J. Hum. Genet.
Thrombocytopenia–absent radius (TAR) syndrome is characterized by hypomegakaryocytic thrombocytopenia and bilateral radial aplasia in the presence of both thumbs. Other frequent associations are congenital heart disease and a high incidence of cow’s milk intolerance. Evidence for autosomal recessive inheritance comes from families with several affected individuals born to unaffected parents, but several other observations argue for a more complex pattern of inheritance. In this study, we describe a common interstitial microdeletion of 200 kb on chromosome 1q21.1 in all 30 investigated patients with TAR syndrome, detected by microarray-based comparative genomic hybridization. Analysis of the parents revealed that this deletion occurred de novo in 25% of affected individuals. Intriguingly, inheritance of the deletion along the maternal line as well as the paternal line was observed. The absence of this deletion in a cohort of control individuals argues for a specific role played by the microdeletion in the pathogenesis of TAR syndrome. We hypothesize that TAR syndrome is associated with a deletion on chromosome 1q21.1 but that the phenotype develops only in the presence of an additional as-yet-unknown modifier (mTAR)
Microduplications encompassing the Sonic hedgehog limb enhancer ZRS are associated with Haas-type polysyndactyly and Laurin-Sandrow syndrome
Laurin-Sandrow syndrome (LSS) is a rare autosomal dominant disorder characterized by polysyndactyly of hands and/or feet, mirror image duplication of the feet, nasal defects, and loss of identity between fibula and tibia. The genetic basis of LSS is currently unknown. LSS shows phenotypic overlap with Haas-type polysyndactyly (HTS) regarding the digital phenotype. Here we report on five unrelated families with overlapping microduplications encompassing the Sonic hedgehog (SHH) limb enhancer ZPA regulatory sequence (ZRS) on chromosome 7q36. Clinically, the patients show polysyndactyly phenotypes and various types of lower limb malformations ranging from syndactyly to mirror image polydactyly with duplications of the fibulae. We show that larger duplications of the ZRS region (>80 kb) are associated with HTS, whereas smaller duplications (<80 kb) result in the LSS phenotype. On the basis of our data, the latter can be clearly distinguished from HTS by the presence of mirror image polysyndactyly of the feet with duplication of the fibula. Our results expand the clinical phenotype of the ZRS-associated syndromes and suggest that smaller duplications (<80 kb) are associated with a more severe phenotype. In addition, we show that these small microduplications within the ZRS region are the underlying genetic cause of Laurin-Sandrow syndrome
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Constan además coordenadas según el meridiano de WashingtonRelieve : lÃneas perpendiculares normalesLeyenda de signos utilizadosInserta : Boston und Umcebunc. - Escala 1:1000000 - - New York und Umcebunc im Maassstabe von 1:1000000 - - Der Sudliche theil von Texas im Anschluss am Blatt 8
Intervalley scattering by acoustic phonons in two-dimensional MoS2 revealed by double-resonance Raman spectroscopy
Double-resonance Raman scattering is a sensitive probe to study the electron-phonon scattering pathways in crystals. For semiconducting two-dimensional transition-metal dichalcogenides, the double-resonance Raman process involves different valleys and phonons in the Brillouin zone, and it has not yet been fully understood. Here we present a multiple energy excitation Raman study in conjunction with density functional theory calculations that unveil the double-resonance Raman scattering process in monolayer and bulk MoS2. Results show that the frequency of some Raman features shifts when changing the excitation energy, and first-principle simulations confirm that such bands arise from distinct acoustic phonons, connecting different valley states. The double-resonance Raman process is affected by the indirect-to-direct bandgap transition, and a comparison of results in monolayer and bulk allows the assignment of each Raman feature near the M or K points of the Brillouin zone. Our work highlights the underlying physics of intervalley scattering of electrons by acoustic phonons, which is essential for valley depolarization in MoS2
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