28 research outputs found
Wnt and Notch signaling pathway involved in wound healing by targeting c-Myc and Hes1 separately
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Delta-like 4 inhibits choroidal neovascularization despite opposing effects on vascular endothelium and macrophages
Get PDFNotch1 controls macrophage recruitment and Notch signaling is activated at sites of endothelial cell anastomosis during retinal angiogenesis in mice
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Myeloid-Specific Blockade of Notch Signaling Attenuates Choroidal Neovascularization through Compromised Macrophage Infiltration and Polarization in Mice
No full textNotch–RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization
No full textVascular Integrity in the Pathogenesis of Brain Arteriovenous Malformation
No full textBrain arteriovenous malformation (bAVM) is an important cause of intracranial hemorrhage (ICH), particularly in the young population. ICH is the first clinical symptom in about 50 % of bAVM patients. The vessels in bAVM are fragile and prone to rupture, causing bleeding into the brain. About 30 % of unruptured and non-hemorrhagic bAVMs demonstrate microscopic evidence of hemosiderin in the vascular wall. In bAVM mouse models, vascular mural cell coverage is reduced in the AVM lesion, accompanied by vascular leakage and microhemorrhage. In this review, we discuss possible signaling pathways involved in abnormal vascular development in bAVM
