4,195 research outputs found
A Microscopic Mechanism for Muscle's Motion
The SIRM (Stochastic Inclined Rods Model) proposed by H. Matsuura and M.
Nakano can explain the muscle's motion perfectly, but the intermolecular
potential between myosin head and G-actin is too simple and only repulsive
potential is considered. In this paper we study the SIRM with different complex
potential and discuss the effect of the spring on the system. The calculation
results show that the spring, the effective radius of the G-actin and the
intermolecular potential play key roles in the motion. The sliding speed is
about calculated from the model which well agrees with
the experimental data.Comment: 9 pages, 6 figure
Do different subjective evaluation criteria reflect distinct constructs?
This is not the published version. Published version available from: http://journals.lww.com/jonmd/pages/default.asp
A scanning drift tube apparatus for spatio-temporal mapping of electron swarms
A "scanning" drift tube apparatus, capable of mapping of the spatio-temporal
evolution of electron swarms, developing between two plane electrodes under the
effect of a homogeneous electric field, is presented. The electron swarms are
initiated by photoelectron pulses and the temporal distributions of the
electron flux are recorded while the electrode gap length (at a fixed electric
field strength) is varied. Operation of the system is tested and verified with
argon gas, the measured data are used for the evaluation of the electron bulk
drift velocity. The experimental results for the space-time maps of the
electron swarms - presented here for the first time - also allow clear
observation of deviations from hydrodynamic transport. The swarm maps are also
reproduced by particle simulations
Solvable Examples of Drift and Diffusion of Ions in Non-uniform Electric Fields
The drift and diffusion of a cloud of ions in a fluid are distorted by an
inhomogeneous electric field. If the electric field carries the center of the
distribution in a straight line and the field configuration is suitably
symmetric, the distortion can be calculated analytically. We examine the
specific examples of fields with cylindrical and spherical symmetry in detail
assuming the ion distributions to be of a generally Gaussian form. The effects
of differing diffusion coefficients in the transverse and longitudinal
directions are included
Endothelial barrier dysfunction in diabetic conduit arteries: a novel method to quantify filtration
The endothelial barrier plays an important role in atherosclerosis, hyperglycemia, and hypercholesterolemia. In the present study, an accurate, reproducible, and user-friendly method was used to further understand endothelial barrier function of conduit arteries. An isovolumic method was used to measure the hydraulic conductivity (Lp) of the intact vessel wall and medial-adventitial layer. Normal arterial segments with diameters from 0.2 to 5.5 mm were used to validate the method, and femoral arteries of diabetic rats were studied as an example of pathological specimens. Various arterial segments confirmed that the volume flux of water per unit surface area was linearly related to intraluminal pressure, as confirmed in microvessels. Lp of the intact wall varied from 3.5 to 22.1 × 10−7 cm·s−1·cmH2O−1 over the pressure range of 7–180 mmHg. Over the same pressure range, Lp of the endothelial barrier changed from 4.4 to 25.1 × 10−7 cm·s−1·cmH2O−1. During perfusion with albumin-free solution, Lp of rat femoral arteries increased from 6.1 to 13.2 × 10−7 cm·s−1·cmH2O−1 over the pressure range of 10–180 mmHg. Hyperglycemia increased Lp of the femoral artery in diabetic rats from 2.9 to 5.5 × 10−7 cm·s−1·cmH2O−1 over the pressure range of 20–135 mmHg. In conclusion, the Lp of a conduit artery can be accurately and reproducibly measured using a novel isovolumic method, which in diabetic rats is hyperpermeable. This is likely due to disruption of the endothelial glycocalyx
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