397 research outputs found
Kinks in the discrete sine-Gordon model with Kac-Baker long-range interactions
We study effects of Kac-Baker long-range dispersive interaction (LRI) between
particles on kink properties in the discrete sine-Gordon model. We show that
the kink width increases indefinitely as the range of LRI grows only in the
case of strong interparticle coupling. On the contrary, the kink becomes
intrinsically localized if the coupling is under some critical value.
Correspondingly, the Peierls-Nabarro barrier vanishes as the range of LRI
increases for supercritical values of the coupling but remains finite for
subcritical values. We demonstrate that LRI essentially transforms the internal
dynamics of the kinks, specifically creating their internal localized and
quasilocalized modes. We also show that moving kinks radiate plane waves due to
break of the Lorentz invariance by LRI.Comment: 11 pages (LaTeX) and 14 figures (Postscript); submitted to Phys. Rev.
Stable two-dimensional dispersion-managed soliton
The existence of a dispersion-managed soliton in two-dimensional nonlinear
Schr\"odinger equation with periodically varying dispersion has been explored.
The averaged equations for the soliton width and chirp are obtained which
successfully describe the long time evolution of the soliton. The slow dynamics
of the soliton around the fixed points for the width and chirp are investigated
and the corresponding frequencies are calculated. Analytical predictions are
confirmed by direct PDE and ODE simulations. Application to a Bose-Einstein
condensate in optical lattice is discussed. The existence of a
dispersion-managed matter-wave soliton in such system is shown.Comment: 4 pages, 3 figures, Submitted to Phys. Rev.
Two-dimensional loosely and tightly bound solitons in optical lattices and inverted traps
We study the dynamics of nonlinear localized excitations (solitons) in
two-dimensional (2D) Bose-Einstein condensates (BECs) with repulsive
interactions, loaded into an optical lattice (OL), which is combined with an
external parabolic potential. First, we demonstrate analytically that a broad
(loosely bound, LB) soliton state, based on a 2D Bloch function near the edge
of the Brillouin zone (BZ), has a negative effective mass (while the mass of a
localized state is positive near the BZ center). The negative-mass soliton
cannot be held by the usual trap, but it is safely confined by an inverted
parabolic potential (anti-trap). Direct simulations demonstrate that the LB
solitons (including the ones with intrinsic vorticity) are stable and can
freely move on top of the OL. The frequency of elliptic motion of the
LB-soliton's center in the anti-trapping potential is very close to the
analytical prediction which treats the solition as a quasi-particle. In
addition, the LB soliton of the vortex type features real rotation around its
center. We also find an abrupt transition, which occurs with the increase of
the number of atoms, from the negative-mass LB states to tightly bound (TB)
solitons. An estimate demonstrates that, for the zero-vorticity states, the
transition occurs when the number of atoms attains a critical number N=10^3,
while for the vortex the transition takes place at N=5x10^3 atoms. The
positive-mass LB states constructed near the BZ center (including vortices) can
move freely too. The effects predicted for BECs also apply to optical spatial
solitons in bulk photonic crystals.Comment: 17 pages, 12 figure
Studies on the clinical significance of nonesterified and total cholesterol in urine
Gas-liquid chromatographic determinations of nonesterified and total urinary cholesterol were performed in 137 normals, 264 patients with various internal diseases without evidence of neoplasias or diseases of the kidney or urinary tract, 497 patients with malignancies and 236 patients with diseases of the kidney, urinary tract infections or prostatic adenoma with residual urine. A normal range (mean±2 SD) of 0.2–2.2 mg/24 hours nonesterified cholesterol (NEC) and of 0.3–3.0 mg/24 hours total cholesterol (TC) was calculated.
Values of urinary cholesterol excretion were independent of age and sex and did not correlate with cholesterol levels in plasma. Patients with various internal diseases, without evidence of neoplasias nor diseases of the kidney or obstruction of the urinary tract, showed normal urinary cholesterol excretions, as did patients with infections of the urinary tract.
However, elevated urinary cholesterol was found in patients with diseases of the kidney or urinary tract obstruction (prostatic adenoma with residual urine), malignant diseases of the urogenital tract and metastasing carcinoma of the breast. In patients with other malignant diseases urinary cholesterol was usually normal.
Lesions of the urothelial cell membranes are considered to be the most likely cause of urinary cholesterol hyperexcretion. The clinical value of urinary cholesterol determinations as a possible screening test for urogenital carcinomas in unselected populations is limited by lacking specificity, expensive methodology and low prevalence of the mentioned carcinomas, although elevated urinary cholesterol excretions have been observed in early clinical stages of urogenital cancers
Nonlinear effects in E Jahn-Teller model: Variational approach with excited phonon states and mode correlations
Interplay of nonlinear and quantum effects in the ground state of the
E Jahn-Teller model was investigated by the {\it variational
approach and exact numerical simulations}. They result in the recognition of
(i) importance of the admixture of {\it the first excited state of the
displaced harmonic oscillator} of the symmetric phonon mode in the ground state
of the system in the selftrapping-dominated regime; (ii) existence of {\it the
region of localized -undisplaced oscillator states} in the
tunneling-dominated regime. The effect (i) occurs owing to significant decrease
of the ground state energy on account of the overlapping contribution of the
symmetric phonon mode between the states of the same parity. This contribution
considerably improves variational results especially in the
selftrapping-dominated regime. Close to the Ee limit, the nonlinear
effects of {\it two-mode correlations} turn to be effective due to the
rotational symmetry of this case. In the tunneling-dominated regime the phonon
wave functions behave like the strongly localized harmonic oscillator ground
state and the effect (i) looses its significance.Comment: 28 pages,6 figure
Dynamics of positive- and negative-mass solitons in optical lattices and inverted traps
We study the dynamics of one-dimensional solitons in the attractive and
repulsive Bose-Einstein condensates (BECs) loaded into an optical lattice (OL),
which is combined with an external parabolic potential. First, we demonstrate
analytically that, in the repulsive BEC, where the soliton is of the gap type,
its effective mass is \emph{negative}. This gives rise to a prediction for the
experiment: such a soliton cannot be not held by the usual parabolic trap, but
it can be captured (performing harmonic oscillations) by an anti-trapping
inverted parabolic potential. We also study the motion of the soliton a in long
system, concluding that, in the cases of both the positive and negative mass,
it moves freely, provided that its amplitude is below a certain critical value;
above it, the soliton's velocity decreases due to the interaction with the OL.
At a late stage, the damped motion becomes chaotic. We also investigate the
evolution of a two-soliton pulse in the attractive model. The pulse generates a
persistent breather, if its amplitude is not too large; otherwise, fusion into
a single fundamental soliton takes place. Collisions between two solitons
captured in the parabolic trap or anti-trap are considered too. Depending on
their amplitudes and phase difference, the solitons either perform stable
oscillations, colliding indefinitely many times, or merge into a single
soliton. Effects reported in this work for BECs can also be formulated for
optical solitons in nonlinear photonic crystals. In particular, the capture of
the negative-mass soliton in the anti-trap implies that a bright optical
soliton in a self-defocusing medium with a periodic structure of the refractive
index may be stable in an anti-waveguide.Comment: 22pages, 9 figures, submitted to Journal of Physics
The Effects of Dietary Linoleic Acid and Hydrophilic Antioxidants on Basal, Peak, and Sustained Metabolism in Flight‐trained European Starlings
Dietary micronutrients have the ability to strongly influence animal physiology and ecology. For songbirds, dietary polyunsaturated fatty acids (PUFAs) and antioxidants are hypothesized to be particularly important micronutrients because of their influence on an individual\u27s capacity for aerobic metabolism and recovery from extended bouts of exercise. However, the influence of specific fatty acids and hydrophilic antioxidants on whole‐animal performance remains largely untested. We used diet manipulations to directly test the effects of dietary PUFA, specifically linoleic acid (18:2n6), and anthocyanins, a hydrophilic antioxidant, on basal metabolic rate (BMR), peak metabolic rate (PMR), and rates of fat catabolism, lean catabolism, and energy expenditure during sustained flight in a wind tunnel in European starlings (Sturnus vulgaris). BMR, PMR, energy expenditure, and fat metabolism decreased and lean catabolism increased over the course of the experiment in birds fed a high (32%) 18:2n6 diet, while birds fed a low (13%) 18:2n6 diet exhibited the reverse pattern. Additionally, energy expenditure, fat catabolism, and flight duration were all subject to diet‐specific effects of whole‐body fat content. Dietary antioxidants and diet‐related differences in tissue fatty acid composition were not directly related to any measure of whole‐animal performance. Together, these results suggest that the effect of dietary 18:2n6 on performance was most likely the result of the signaling properties of 18:2n6. This implies that dietary PUFA influence the energetic capabilities of songbirds and could strongly influence songbird ecology, given their availability in terrestrial systems
Recommendations from an international expert panel on the use of neoadjuvant (primary) systemic treatment of operable breast cancer: new perspectives 2006
Neoadjuvant (primary systemic) treatment has become a standard option for primary operable disease for patients who are candidates for adjuvant systemic chemotherapy, irrespective of the size of the tumor. Because of new treatments and new understandings of breast cancer, however, recommendations published in 2006 regarding neoadjuvant treatment for operable disease required updating. Therefore, a third international panel of representatives of a number of breast cancer clinical research groups was convened in September 2006 to update these recommendations. As part of this effort, data published to date were critically reviewed and indications for neoadjuvant treatment were newly define
Pegfilgrastim ± ciprofloxacin for primary prophylaxis with TAC (docetaxel/doxorubicin/cyclophosphamide) chemotherapy for breast cancer. Results from the GEPARTRIO study
Background: TAC (docetaxel/doxorubicin/cyclophosphamide) is associated with high incidences of grade 4 neutropenia and febrile neutropenia (FN). This analysis compared the efficacies of four regimens for primary prophylaxis of FN and related toxic effects in breast cancer patients receiving neoadjuvant TAC. Patients and methods: Patients with stage T2-T4 primary breast cancer were scheduled to receive 6-8 cycles of TAC. Primary prophylaxis was: ciprofloxacin 500 mg orally twice daily on days 5-14 (n = 253 patients; 1478 cycles), daily granulocyte colony-stimulating factor (G-CSF) (filgrastim 5 μg/kg/day or lenograstim 150 μg/m2/day) on days 5-10 (n = 377; 2400 cycles), pegfilgrastim 6 mg on day 2 (n = 305; 1930 cycles), or pegfilgrastim plus ciprofloxacin (n = 321; 1890 cycles). Results: Pegfilgrastim with/without ciprofloxacin was significantly more effective than daily G-CSF or ciprofloxacin in preventing FN (5% and 7% versus 18% and 22% of patients; all P < 0.001), grade 4 neutropenia, and leukopenia. Pegfilgrastim plus ciprofloxacin completely prevented first cycle FN (P < 0.01 versus pegfilgrastim alone) and fatal neutropenic events. Conclusion: Ciprofloxacin alone, or daily G-CSF from day 5-10 (as in common practice), provided suboptimal protection against FN and related toxic effects in patients receiving TAC. Pegfilgrastim was significantly more effective in this setting, especially if given with ciprofloxaci
The nonlinear Schroedinger equation for the delta-comb potential: quasi-classical chaos and bifurcations of periodic stationary solutions
The nonlinear Schroedinger equation is studied for a periodic sequence of
delta-potentials (a delta-comb) or narrow Gaussian potentials. For the
delta-comb the time-independent nonlinear Schroedinger equation can be solved
analytically in terms of Jacobi elliptic functions and thus provides useful
insight into the features of nonlinear stationary states of periodic
potentials. Phenomena well-known from classical chaos are found, such as a
bifurcation of periodic stationary states and a transition to spatial chaos.
The relation of new features of nonlinear Bloch bands, such as looped and
period doubled bands, are analyzed in detail. An analytic expression for the
critical nonlinearity for the emergence of looped bands is derived. The results
for the delta-comb are generalized to a more realistic potential consisting of
a periodic sequence of narrow Gaussian peaks and the dynamical stability of
periodic solutions in a Gaussian comb is discussed.Comment: Enhanced and revised version, to appear in J. Nonlin. Math. Phy
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