Multiprotein DNA looping

DNA looping plays a fundamental role in a wide variety of biological processes, providing the backbone for long range interactions on DNA. Here we develop the first model for DNA looping by an arbitrarily large number of proteins and solve it analytically in the case of identical binding. We uncover a switch-like transition between looped and unlooped phases and identify the key parameters that control this transition. Our results establish the basis for the quantitative understanding of fundamental cellular processes like DNA recombination, gene silencing, and telomere maintenance.Comment: 11 pages, 4 figure

Intense molecular emission from the Lagoon nebula, M8

The discovery is reported of the second strongest source of mm and submm wavelength CO line emission, towards M8, the Lagoon Nebula in Sagittarius. The ~31 M⊙ molecular core has dimensions ~0.2 x 0.3pc and is centred on the O7V star Herschel 36 (H36), near the Hourglass Nebula in the core of M8. Emission from the CO line wings extends to the north and south of the Hourglass, although a lack of near-IR H2 emission indicates that outflow activity is much less prominent than in many active star-formation regions, and suggests that the CO line wings may trace the expanding edge of a cavity around H36. The molecular line data are compared with new near-IR narrow-band, continuum-subtracted images in He I, H2, and H,+ (Brγ) lines and archival HST emission-line images in Hα, [O III], and [S II]. The optical and near-IR data are found to be broadly consistent with previous photo-ionisation models of the Hourglass, which is excited by H 36. However, there are variations in the He I/Brγ line ratio which are difficult to explain

A preliminary study of certain electrical properties of stannic oxide ceramics

Tin oxide ceramics - fabrication techniques, and electrical and optical properties determinatio

Magnetic Field Structure around Low-Mass Class 0 Protostars: B335, L1527 and IC348-SMM2

We report new 350 micron polarization observations of the thermal dust emission from the cores surrounding the low-mass, Class 0 YSOs L1527, IC348-SMM2 and B335. We have inferred magnetic field directions from these observations, and have used them together with results in the literature to determine whether magnetically regulated core-collapse and star-formation models are consistent with the observations. These models predict a pseudo-disk with its symmetry axis aligned with the core magnetic field. The models also predict a magnetic field pinch structure on a scale less than or comparable to the infall radii for these sources. In addition, if the core magnetic field aligns (or nearly aligns) the core rotation axis with the magnetic field before core collapse, then the models predict the alignment (or near alignment) of the overall pinch field structure with the bipolar outflows in these sources. We show that if one includes the distorting effects of bipolar outflows on magnetic fields, then in general the observational results for L1527 and IC348-SMM2 are consistent with these magnetically regulated models. We can say the same for B335 only if we assume the distorting effects of the bipolar outflow on the magnetic fields within the B335 core are much greater than for L1527 and IC348-SMM2. We show that the energy densities of the outflows in all three sources are large enough to distort the magnetic fields predicted by magnetically regulated models.Comment: Accepted for publication in The Astrophysical Journa

Neutral Hydrogen Associated with NGC 7129

Observations of the environment of the star-forming region NGC 7129 obtained with an angular resolution of 1' in the 21 cm line of H I are described. Two features of the image are extensively discussed: (1) a ring of H I emission about 30' in extent and (2) a relatively dense concentration of H I with unusually wide line profiles positionally coincident with the B star BD +65°1638. The H I ring is consistent with photodissociation of H2 by the interstellar UV radiation field at the surface of an extended molecular cloud in which both BD +65°1638 and NGC 7129 are situated. We further show that BD +65°1638 appears to be an unusual example of a "dissociating star" surrounded by an extensive region of photodissociated H2 and accompanied by a small H II region. The derived spectral type (B2.5) and the absolute magnitude for BD +65°1638 further suggest that the latter is very close to the birthline. The very young stellar age implied by the parameters of the H I region, considerably less than 104 yr, is discussed, and the properties of the H I region are compared with those of the prototype for this rare class of objects. We discuss both aspects within the context of star formation in NGC 7129

Multi-level study of C3H2: The first interstellar hydrocarbon ring

Cyclic species in the interstellar medium have been searched for almost since the first detection of interstellar polyatomic molecules. Eleven different C3H2 rotational transitions were detected; 9 of which were studied in TMC-1, a nearby dark dust cloud, are shown. The 1 sub 10 yields 1 sub 01 and 2 sub 20 yields 2 sub 11 transitions were observed with the 43 m NRAO telescope, while the remaining transitions were detected with the 14 m antenna of the Five College Radio Observatory (FCRAO). The lines detected in TMC-1 have energies above the ground state ranging from 0.9 to 17.1 K and consist of both ortho and para species. Limited maps were made along the ridge for several of the transitions. The HC3N J = 2 yields 1 transition were mapped simultaneously with the C3H2 1 sub 10 yields 1 sub 01 line and therefore can compare the distribution of this ring with a carbon chain in TMC-1. C3H2 is distributed along a narrow ridge with a SE - NW extension which is slightly more extended than the HC2N J = 2 yields 1. Gaussian fits gives a FWHP extension of 8'5 for C3H2 while HC3N has a FWHP of 7'. The data show variations of the two velocity components along the ridge as a function of transition. Most of the transitions show a peak at the position of strongest HC3N emission while the 2 sub 21 yields 2 sub 10 transition shows a peak at the NH3 position

QAA subject benchmark statement architecture : version for consultation December 2019

The Statement is intended to guide lecturers and course leaders in the design of academic courses leading to qualifications in architecture, it will also be useful to those developing other related courses. Higher education providers may need to consider other reference points in addition to this Statement in designing, delivering and reviewing courses. These may include requirements set out by the Architects Registration Board (ARB), the Royal Institute of British Architects (RIBA) and the Institute for Apprenticeships and Technical Education (IfATE). Providers may also need to consider industry or employer expectations. Individual higher education providers will decide how they use this information. The broad subject of architecture is both academic and vocational. The bachelor's award for architecture is the first stage of the typical education of an architect. This is typically either a BSc or a BA degree. The second stage of academic qualification is a master's level degree, typically in the form of a two-year MArch, which is defined as an undergraduate master's award. Architecture qualifications typically require a total of 360 (Credit Accumulation and Transfer Scheme, or CATS) credits at bachelor's level and 240 (CATS) credits within a master's level degree. While this may equate to five years of 120 (CATS) credits each, higher education providers may construct alternatives to enable flexibility in student learning. This Statement seeks to encapsulate the nature of a rich and diverse academic discipline. It is not intended to prescribe a curriculum, but rather describes the broad intellectual territory within which individual higher education providers will locate their courses of study in architecture