Generalization of the NpNnN_pN_n Scheme and the Structure of the Valence Space

The $N_pN_n$ scheme, which has been extensively applied to even-even nuclei, is found to be a very good benchmark for odd-even, even-odd, and doubly-odd nuclei as well. There are no apparent shifts in the correlations for these four classes of nuclei. The compact correlations highlight the deviant behavior of the Z=78 nuclei, are used to deduce effective valence proton numbers near Z=64, and to study the evolution of the Z=64 subshell gap.Comment: 10 pages, 4 figure

Extra-Thymic Physiological T Lineage Progenitor Activity Is Exclusively Confined to Cells Expressing either CD127, CD90, or High Levels of CD117

T cell development depends on continuous recruitment of progenitors from bone marrow (BM) to the thymus via peripheral blood. However, both phenotype and functional characteristics of physiological T cell precursors remain ill-defined. Here, we characterized a putative CD135+CD27+ T cell progenitor population, which lacked expression of CD127, CD90, and high levels of CD117 and was therefore termed triple negative precursor (TNP). TNPs were present in both BM and blood and displayed robust T lineage potential, but virtually no myeloid or B lineage potential, in vitro. However, TNPs did not efficiently generate T lineage progeny after intravenous or intrathymic transfer, suggesting that a physiological thymic microenvironment does not optimally support T cell differentiation from TNPs. Thus, we propose that physiological T cell precursors are confined to populations expressing either CD127, CD90, or high levels of CD117 in addition to CD135 and CD27 and that TNPs may have other physiological functions

Low-lying levels in Cu-57 and the rp process

Journals published by the American Physical Society can be found at http://publish.aps.org/The level scheme of Cu-57 is investigated via the H-1(Ni-58,Cu-57-gamma)2n reaction by using the recoil mass spectrometer MARS at the Texas AandM Cyclotron Institute. Three low-lying excited states are observed in Cu-57 at 1028 +/- 4, 1106 +/- 4, and 2398 +/- 10 keV. The results are compared with well known excited states of the mirror nucleus Ni-57. Th, measured excited states of Cu-57 allow recalculation of the astrophysical reaction rate for the stellar radiative proton capture reaction Ni-56(p,gamma)Cu-57

Decay of Cs145 to levels of Ba145

An investigation of the - decay of 0.59 s Cs145 into levels of Ba145 was undertaken to search for evidence of intrinsic reflection asymmetry in light rare-earth nuclei. E, I, - coincidence, angular correlation coefficients, and internal conversion coefficients were measured. The level scheme for Ba145 up to 1.3 MeV has been constructed. The proposed spin and parity assignments are based upon the measured transition multipolarities and the ?(hy angular correlation coefficients. The levels at 112, 175, 277, and 416 keV may be members of a decoupled K=1/2- band with a decoupling parameter of -2 and a rotational parameter of 20 keV. The octupole deformed rotational structure which is observed in the light odd-A actinides is not readily identified in Ba145. © 1986 The American Physical Society

''Bare'' single-particle energies in Ni-56

Journals published by the American Physical Society can be found at http://publish.aps.org/The structure of the low-lying levels in the mirror nuclei Ni-57 and Cu-57 is described within the extended unified model. The problem of single-particle energies in Ni-56 is treated in detail. ''Bare'' single-particle energies are extracted from existing experimental data for the energy levels in Ni-57 and Cu-57 by carefully considering the influence of the coupling to excitations of the core. Important contributions arise, influencing especially the results on the spin-orbit splitting. The differences between the Coulomb energy shifts of various orbitals in Ni-56 are discussed and compared with those resulting from Hartree-Fock calculations carried out using a broad range of Skyrme interactions. The parameters of the Woods-Saxon potential reproducing these neutron ''bare'' single-particle energies and the charge root-mean-square radius of Ni-56 are extracted. It is demonstrated that the contributions associated with the Thomas-Ehrman effect and the electromagnetic spin-orbit interaction are important and large enough to account for the differences between the Coulomb energy shifts of the single-particle levels in Ni-56

Nuclear spectroscopy of neutron rich A=147 nuclides: decay of /sup 147 /Cs, /sup 147/Ba and /sup 147/La

A study of the beta decay of neutron rich nuclides of the A=147 chain is carried out at the TRIS

T lymphoid differentiation in human bone marrow

The unique role of the thymus in the development of T cells was established >4 decades ago. To elucidate how uncommitted lymphoid progenitor cells are instructed to migrate from bone marrow to the thymus to undergo T lymphoid differentiation, we generated and analyzed a genome-wide gene expression profile of CD7(+) CD10(+) human bone marrow T cell lineage precursors (TLPs) by using the serial analysis of gene expression technique. Unexpectedly, the serial analysis of gene expression profile identified a high number of (pre-) T cell receptor antigen (TCR)-related transcripts in bone marrow TLPs. To determine the configuration of the TCRβ locus in these cells at a quantitative level, we sorted and analyzed bone marrow TLPs from five donors by single-cell PCR. Similar proportions of TLPs harbored TCRβ germ-line alleles, D-J, or V-DJ gene rearrangements. Thus, bone marrow TLPs are heterogenous with respect to TCRβ rearrangement status, suggesting an active recombination machinery that is consistent with the expression of RAG1, RAG2, and TdT in this population. As a hallmark of ongoing TCRβ V-DJ rearrangement, we could amplify broken-ended recombination-signal sequence DNA intermediates from bone marrow TLPs, but not from mature T cells by ligation-mediated PCR. Approximately half of the TCRβ rearrangements were compatible with the expression of a functional pre-TCR, which is in agreement with surface expression of pre-Tα on bone marrow TLPs as shown by confocal laser microscopy and flow cytometry. At a frequency <0.5% of mononucleated cells in human bone marrow, this population is rare, yet it exemplifies T lymphoid differentiation in the human already before immigration into the thymus

l-forbidden Gamow-Teller beta decay of Cu-57

Journals published by the American Physical Society can be found at http://publish.aps.org/Absolute branching ratios for the beta decay of Cu-57 to excited states up to 3.3 MeV in Ni-57 have been determined, including the rho-forbidden Gamow-Teller transition to the first excited state in Ni-57. Four transitions to excited states at 0.768, 1.113, 2.443, and 3.007 MeV are observed in addition to the superallowed decay to the ground state of Ni-57. The, measured branching ratio to the ground state is 89.9 +/- 0.8% and the branching ratios to the four excited states are 0.94 +/- 0.09%, 8.6 +/- 0.6%, 0.17 +/- 0.03%, and 0.35 +/- 0.04%, respectively. In addition we have measured the Cu-57 half-life and find it to be 196.3 +/- 0.7 ms, which is in good agreement with the most recent measurement. B(GT) values have been extracted from the new results and are compared to shell model calculations

Treatment of 4T1 Metastatic Breast Cancer with Combined Hypofractionated Irradiation and Autologous T-Cell Infusion

The goal of this study was to determine whether a combination of local tumor irradiation and autologous T-cell transplantation can effectively treat metastatic 4T1 breast cancer in mice. BALB/c mice were injected subcutaneously with luciferase-labeled 4T1 breast tumor cells and allowed to grow for 21 days, at which time metastases appeared in the lungs. Primary tumors were treated at that time with 3 daily fractions of 20 Gy of radiation each. Although this approach could eradicate primary tumors, tumors in the lungs grew progressively. We attempted to improve efficacy of the radiation by adding autologous T-cell infusions. Accordingly, T cells were purified from the spleens of tumor-bearing mice after completion of irradiation and cryopreserved. Cyclophosphamide was administered thereafter to induce lympho-depletion, followed by T-cell infusion. Although the addition of cyclophosphamide to irradiation did not improve survival or reduce tumor progression, the combination of radiation, cyclophosphamide and autologous T-cell infusion induced durable remissions and markedly improved survival. We conclude that the combination of radiation and autologous T-cell infusion is an effective treatment for metastatic 4T1 breast cancer. (C) 2014 by Radiation Research Societyopen1188sciescopu