1,002 research outputs found
Optimal sequential fingerprinting: Wald vs. Tardos
We study sequential collusion-resistant fingerprinting, where the
fingerprinting code is generated in advance but accusations may be made between
rounds, and show that in this setting both the dynamic Tardos scheme and
schemes building upon Wald's sequential probability ratio test (SPRT) are
asymptotically optimal. We further compare these two approaches to sequential
fingerprinting, highlighting differences between the two schemes. Based on
these differences, we argue that Wald's scheme should in general be preferred
over the dynamic Tardos scheme, even though both schemes have their merits. As
a side result, we derive an optimal sequential group testing method for the
classical model, which can easily be generalized to different group testing
models.Comment: 12 pages, 10 figure
A high resolution, high frame rate detector based on a microchannel plate read out with the Medipix2 counting CMOS pixel chip.
The future of ground-based optical astronomy lies with advancements in adaptive optics (AO) to overcome the limitations that the atmosphere places on high resolution imaging. A key technology for AO systems on future very large telescopes are the wavefront sensors (WFS) which detect the optical phase error and send corrections to deformable mirrors. Telescopes with >30 m diameters will require WFS detectors that have large pixel formats (512x512), low noise (<3 e-/pixel) and very high frame rates (~1 kHz). These requirements have led to the idea of a bare CMOS active pixel device (the Medipix2 chip) functioning in counting mode as an anode with noiseless readout for a microchannel plate (MCP) detector and at 1 kHz continuous frame rate. First measurement results obtained with this novel detector are presented both for UV photons and beta particles
Possible detection of two giant extrasolar planets orbiting the eclipsing polar UZ Fornacis
We present new high-speed, multi-observatory, multi-instrument photometry of
the eclipsing polar UZ For in order to measure precise mid-eclipse times with
the aim of detecting any orbital period variations. When combined with
published eclipse times and archival data spanning ~27 years, we detect
departures from a linear and quadratic trend of ~60 s. The departures are
strongly suggestive of two cyclic variations of 16(3) and 5.25(25) years. The
two favoured mechanisms to drive the periodicities are either two giant
extrasolar planets as companions to the binary (with minimum masses of
6.3(1.5)M(Jupiter) and 7.7(1.2)M(Jupiter)) or a magnetic cycle mechanism (e.g.
Applegate's mechanism) of the secondary star. Applegate's mechanism would
require the entire radiant energy output of the secondary and would therefore
seem to be the least likely of the two, barring any further refinements in the
effect of magnetic fieilds (e.g. those of Lanza et al.). The two planet model
can provide realistic solutions but it does not quite capture all of the
eclipse times measurements. A highly eccentric orbit for the outer planet would
fit the data nicely, but we find that such a solution would be unstable. It is
also possible that the periodicities are driven by some combination of both
mechanisms. Further observations of this system are encouraged.Comment: 10 pages, 4 figures, 2 table
Decision and function problems based on boson sampling
Boson sampling is a mathematical problem that is strongly believed to be
intractable for classical computers, whereas passive linear interferometers can
produce samples efficiently. So far, the problem remains a computational
curiosity, and the possible usefulness of boson-sampling devices is mainly
limited to the proof of quantum supremacy. The purpose of this work is to
investigate whether boson sampling can be used as a resource of decision and
function problems that are computationally hard, and may thus have
cryptographic applications. After the definition of a rather general
theoretical framework for the design of such problems, we discuss their
solution by means of a brute-force numerical approach, as well as by means of
non-boson samplers. Moreover, we estimate the sample sizes required for their
solution by passive linear interferometers, and it is shown that they are
independent of the size of the Hilbert space.Comment: Close to the version published in PR
Tema Con Variazioni: Quantum Channel Capacity
Channel capacity describes the size of the nearly ideal channels, which can
be obtained from many uses of a given channel, using an optimal error
correcting code. In this paper we collect and compare minor and major
variations in the mathematically precise statements of this idea which have
been put forward in the literature. We show that all the variations considered
lead to equivalent capacity definitions. In particular, it makes no difference
whether one requires mean or maximal errors to go to zero, and it makes no
difference whether errors are required to vanish for any sequence of block
sizes compatible with the rate, or only for one infinite sequence.Comment: 32 pages, uses iopart.cl
The selective phosphodiesterase 4 inhibitor roflumilast and phosphodiesterase 3/4 inhibitor pumafentrine reduce clinical score and TNF expression in experimental colitis in mice.
The specific inhibition of phosphodiesterase (PDE)4 and dual inhibition of PDE3 and PDE4 has been shown to decrease inflammation by suppression of pro-inflammatory cytokine synthesis. We examined the effect of roflumilast, a selective PDE4 inhibitor marketed for severe COPD, and the investigational compound pumafentrine, a dual PDE3/PDE4 inhibitor, in the preventive dextran sodium sulfate (DSS)-induced colitis model. The clinical score, colon length, histologic score and colon cytokine production from mice with DSS-induced colitis (3.5% DSS in drinking water for 11 days) receiving either roflumilast (1 or 5 mg/kg body weight/d p.o.) or pumafentrine (1.5 or 5 mg/kg/d p.o.) were determined and compared to vehicle treated control mice. In the pumafentrine-treated animals, splenocytes were analyzed for interferon-γ (IFNγ) production and CD69 expression. Roflumilast treatment resulted in dose-dependent improvements of clinical score (weight loss, stool consistency and bleeding), colon length, and local tumor necrosis factor-α (TNFα) production in the colonic tissue. These findings, however, were not associated with an improvement of the histologic score. Administration of pumafentrine at 5 mg/kg/d alleviated the clinical score, the colon length shortening, and local TNFα production. In vitro stimulated splenocytes after in vivo treatment with pumafentrine showed a significantly lower state of activation and production of IFNγ compared to no treatment in vivo. These series of experiments document the ameliorating effect of roflumilast and pumafentrine on the clinical score and TNF expression of experimental colitis in mice
Organic narrowband near-infrared photodetectors based on intermolecular charge-transfer absorption
Blending organic electron donors and acceptors yields intermolecular charge-transfer states with additional optical transitions below their optical gaps. In organic photovoltaic devices, such states play a crucial role and limit the operating voltage. Due to its extremely weak nature, direct intermolecular charge-transfer absorption often remains undetected and unused for photocurrent generation. Here, we use an optical microcavity to increase the typically negligible external quantum efficiency in the spectral region of charge-transfer absorption by more than 40 times, yielding values over 20%. We demonstrate narrowband detection with spectral widths down to 36 nm and resonance wavelengths between 810 and 1,550 nm, far below the optical gap of both donor and acceptor. The broad spectral tunability via a simple variation of the cavity thickness makes this innovative, flexible and potentially visibly transparent device principle highly suitable for integrated low-cost spectroscopic near-infrared photodetection
Large-Amplitude Ultraviolet Variations in the RR Lyrae Star ROTSE-I J143753.84+345924.8
The NASA Galaxy Evolution Explorer (GALEX) satellite has obtained
simultaneous near and far ultraviolet light curves of the ROTSE-I Catalog RR
Lyrae ab-type variable star J143753.84+345924.8. A series of 38 GALEX Deep
Imaging Survey observations well distributed in phase within the star's
0.56432d period shows an AB=4.9mag variation in the far UV (1350-1750A) band
and an AB=1.8mag variation in the near UV (1750-2750A) band, compared with only
a 0.8mag variation in the broad, unfiltered ROTSE-I (4500-10000A) band. These
GALEX UV observations are the first to reveal a large RR Lyrae amplitude
variation at wavelengths below 1800A. We compare the GALEX and ROTSE-I
observations to predictions made by recent Kurucz stellar atmosphere models. We
use published physical parameters for the comparable period (0.57433d),
well-observed RR Lyrae star WY Antliae to compute predicted FUV, NUV, and
ROTSE-I light curves for J143753.84+345924.8. The observed light curves agree
with the Kurucz predictions for [Fe/H]=-1.25 to within AB=0.2mag in the GALEX
NUV and ROTSE-I bands, and within 0.5mag in the FUV. At all metallicities
between solar and one hundredth solar, the Kurucz models predict 6-8mag of
variation at wavelengths between 1000-1700A. Other variable stars with similar
temperature variations, such as Cepheids, should also have large-amplitude FUV
light curves, observable during the ongoing GALEX imaging surveys.Comment: This paper will be published as part of the Galaxy Evolution Explorer
(GALEX) Astrophysical Journal Letters Special Issue. Links to the full set of
papers will be available at http:/www.galex.caltech.edu/PUBLICATIONS after
November 22, 200
Early N-terminal pro-B-type natriuretic peptide is associated with cardiac complications and function during pregnancy in congenital heart disease
Background: Elevated N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels at 20 weeksâ gestation predict adverse cardiovascular (CV) complications during pregnancy in women with congenital heart disease (CHD). To improve early risk assessment in these women, we investigated the predictive value of first-trimester NT-proBNP for CV complications and its association with ventricular function during pregnancy. Methods: Pregnant women with CHD, previously enrolled in a prospective national study or evaluated by an identical protocol, were included. Clinical data, echocardiographic evaluation and NT-proBNP measurements were obtained at 12, 20 and 32 weeksâ gestation. Elevated NT-proBNP was defined as >âŻ235âŻpg/ml (95th percentile reference value of healthy pregnant women in the literature). Results: We examined 126 females (mean age 29 years). Elevated NT-proBNP at 12 weeks was associated with CV complications (nâŻ= 7, 5.6%, odds ratio 10.9, pâŻ= 0.004). Arrhythmias were the most common complication (71%). The negative predictive value of low NT-proBNP to exclude CV complications was 97.2%. In women with CV complications, NT-proBNP levels remained high throughout pregnancy, while a decrease was seen in women without CV complications (pâŻ<âŻ0.001 for interaction between group and time). At 12 weeks, higher NT-proBNP levels were associated with impaired subpulmonary ventricular function (pâŻ<âŻ0.001) and also with a decline in subpulmonary ventricular function later in pregnancy (pâŻ= 0.012). Conclusions: In this study, first-trimester NT-proBNP levels were associated with adverse CV complications and a decline in subpulmonary ventricular function later in pregnancy in women with CHD. Early NT-proBNP evaluation is useful for tailored care in pregnant women with CHD
- âŠ