448 research outputs found
Mean-field analysis of a dynamical phase transition in a cellular automaton model for collective motion
A cellular automaton model is presented for random walkers with biologically
motivated interactions favoring local alignment and leading to collective
motion or swarming behavior. The degree of alignment is controlled by a
sensitivity parameter, and a dynamical phase transition exhibiting spontaneous
breaking of rotational symmetry occurs at a critical parameter value. The model
is analyzed using nonequilibrium mean field theory: Dispersion relations for
the critical modes are derived, and a phase diagram is constructed. Mean field
predictions for the two critical exponents describing the phase transition as a
function of sensitivity and density are obtained analytically.Comment: 4 pages, 4 figures, final version as publishe
The effect of skin fatty acids on Staphylococcus aureus
Staphylococcus aureus is a commensal of the human nose and skin. Human skin fatty acids, in particular cis-6-hexadecenoic acid (C-6-H), have high antistaphylococcal activity and can inhibit virulence determinant production. Here, we show that sub-MIC levels of C-6-H result in induction of increased resistance. The mechanism(s) of C-6-H activity was investigated by combined transcriptome and proteome analyses. Proteome analysis demonstrated a pleiotropic effect of C-6-H on virulence determinant production. In response to C-6-H, transcriptomics revealed altered expression of over 500 genes, involved in many aspects of virulence and cellular physiology. The expression of toxins (hla, hlb,hlgBC) was reduced, whereas that of host defence evasion components (cap, sspAB, katA) was increased. In particular, members of the SaeRS regulon had highly reduced expression, and the use of specific mutants revealed that the effect on toxin production is likely mediated via SaeRS
Global Diffusion in a Realistic Three-Dimensional Time-Dependent Nonturbulent Fluid Flow
We introduce and study the first model of an experimentally realizable
three-dimensional time-dependent nonturbulent fluid flow to display the
phenomenon of global diffusion of passive-scalar particles at arbitrarily small
values of the nonintegrable perturbation. This type of chaotic advection,
termed {\it resonance-induced diffusion\/}, is generic for a large class of
flows.Comment: 4 pages, uuencoded compressed postscript file, to appear in Phys.
Rev. Lett. Also available on the WWW from http://formentor.uib.es/~julyan/,
or on paper by reques
Stat1 nuclear translocation by nucleolin upon monocyte differentiation
BACKGROUND: Members of the signal transducer and activator of transcription (Stat) family of transcription factors traverse the nuclear membrane through a specialized structure, called the nuclear pore complex (NPC), which represents a selective filter for the import of proteins. Karyophilic molecules can bind directly to a subset of proteins of the NPC, collectively called nucleoporins. Alternatively, the transport is mediated via a carrier molecule belonging to the importin/karyopherin superfamily, which transmits the import into the nucleus through the NPC. METHODOLOGY/PRINCIPAL FINDINGS: In this study, we provide evidence for an alternative Stat1 nuclear import mechanism, which is mediated by the shuttle protein nucleolin. We observed Stat1-nucleolin association, nuclear translocation and specific binding to the regulatory DNA element GAS. Using expression of nucleolin transgenes, we found that the nuclear localization signal (NLS) of nucleolin is responsible for Stat1 nuclear translocation. We show that this mechanism is utilized upon differentiation of myeloid cells and is specific for the differentiation step from monocytes to macrophages. CONCLUSIONS/SIGNIFICANCE: Our data add the nucleolin-Stat1 complex as a novel functional partner for the cell differentiation program, which is uniquely poised to regulate the transcription machinery via Stat1 and nuclear metabolism via nucleolin
White matter integrity in mice requires continuous myelin synthesis at the inner tongue
Myelin, the electrically insulating sheath on axons, undergoes dynamic changes over time. However, it is composed of proteins with long lifetimes. This raises the question how such a stable structure is renewed. Here, we study the integrity of myelinated tracts after experi- mentally preventing the formation of new myelin in the CNS of adult mice, using an inducible Mbp null allele. Oligodendrocytes survive recombination, continue to express myelin genes, but they fail to maintain compacted myelin sheaths. Using 3D electron microscopy and mass spectrometry imaging we visualize myelin-like membranes failing to incorporate adaxonally, most prominently at juxta-paranodes. Myelinoid body formation indicates degradation of existing myelin at the abaxonal side and the inner tongue of the sheath. Thinning of compact myelin and shortening of internodes result in the loss of about 50% of myelin and axonal pathology within 20 weeks post recombination. In summary, our data suggest that functional axon-myelin units require the continuous incorporation of new myelin membranes
Keeping the collectivity in mind?
The key question in this three way debate is the role of the collectivity and of agency. Collins and Shrager debate whether cognitive psychology has, like the sociology of knowledge, always taken the mind to extend beyond the individual. They agree that irrespective of the history, socialization is key to understanding the mind and that this is compatible with Clark’s position; the novelty in Clark’s “extended mind” position appears to be the role of the material rather than the role of other minds. Collins and Clark debate the relationship between self, agency, and the human collectivity. Collins argues that the Clark’s extended mind fails to stress the asymmetry of the relationship between the self and its material “scaffolding.” Clark accepts that there is asymmetry but that an asymmetrical ensemble is sufficient to explain the self. Collins says that we know too little about the material world to pursue such a model to the exclusion of other approaches including that both the collectivity and language have agency. The collectivity must be kept in mind! (Though what follows is a robust exchange of views it is also a cooperative effort, authors communicating “backstage” with each other to try to make the disagreements as clear and to the point as possible.
Theoretical study of the absorption spectra of the sodium dimer
Absorption of radiation from the sodium dimer molecular states correlating to
Na(3s)-Na(3s) is investigated theoretically. Vibrational bound and continuum
transitions from the singlet X Sigma-g+ state to the first excited singlet A
Sigma-u+ and singlet B Pi-u states and from the triplet a Sigma-u+ state to the
first excited triplet b Sigma-g+ and triplet c Pi-g states are studied
quantum-mechanically. Theoretical and experimental data are used to
characterize the molecular properties taking advantage of knowledge recently
obtained from ab initio calculations, spectroscopy, and ultra-cold atom
collision studies. The quantum-mechanical calculations are carried out for
temperatures in the range from 500 to 3000 K and are compared with previous
calculations and measurements where available.Comment: 19 pages, 8 figures, revtex, eps
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