Role of Schizosaccharomyces pombe RecQ homolog recombination and checkpoint genes in UV Damage tolerance

The cellular responses to DNA damage are complex and include direct DNA repair pathways that remove the damage and indirect damage responses which allow cells to survive DNA damage that has not been, or cannot be, removed. We have identified the gene mutated in the rad12.502 strain as a Schizosaccharomyces pombe recQ homolog. The same gene (designated rqh1) is also mutated in the hus2.22 mutant. We show that Rqh1 is involved in a DNA damage survival mechanism which prevents cell death when UV-induced DNA damage cannot be removed. This pathway also requires the correct functioning of the recombination machinery and the six checkpoint tad gene products plus the Cds1 kinase. Our data suggest that Rqh1 operates during S phase as part of a mechanism which prevents DNA damage causing cell lethality. This process may involve the bypass of DNA damage sites by the replication fork. Finally, in contrast with the reported literature, we do not find that rqh1 (rad12) mutant cells are defective in UV dimer endonuclease activity

Effect of a moderate-intensity demonstration walk on accuracy of physical activity self-report.

Background/Objective:Providing a demonstration of a 10-minute bout of moderate-to-vigorous intensity physical activity (MVPA) immediately prior to subjective reporting of MVPA could influence self-reported activity by calibrating both duration and intensity. We assessed the effect of a demonstration of MVPA on subsequent MVPA recall, and explored whether this improved agreement with objective measures of MVPA. Methods:A total of 846 individuals participated in four different physical activity interventions; two of which included a 10-minute moderate-intensity demonstration walk on a treadmill at baseline and 6-month visits immediately prior to reporting MVPA. Participants from three studies also wore accelerometers during the week overlapping with self-reported MVPA. Results:Overall, those completing the demonstration walk reported significantly fewer minutes of MVPA per week at baseline (b = -11.69, standard error = 2.53, p < 0.01). The effect of the demonstration walk at 6 months was not significant (p = 0.06). Correlations with accelerometers at baseline were higher in the two studies with the demonstration walk (ρ = 0.28, 0.26) than the study without (ρ = 0.04). Correlations with accelerometers increased overall from baseline to follow-up. Conclusion:A 10-minute demonstration of MVPA was associated with reporting fewer minutes of MVPA and improved agreement with objective PA measures at baseline. These findings support combining self-report PA assessments with hands-on MVPA demonstrations

Working wetlands: classifying wetland potential for agriculture

Wetlands / Ecology / Natural resources / Social aspects / Case studies / Zanzibar / Tanzania / Zimbabwe / Swaziland

Stability criterion for self-similar solutions with a scalar field and those with a stiff fluid in general relativity

A stability criterion is derived in general relativity for self-similar solutions with a scalar field and those with a stiff fluid, which is a perfect fluid with the equation of state $P=\rho$. A wide class of self-similar solutions turn out to be unstable against kink mode perturbation. According to the criterion, the Evans-Coleman stiff-fluid solution is unstable and cannot be a critical solution for the spherical collapse of a stiff fluid if we allow sufficiently small discontinuity in the density gradient field in the initial data sets. The self-similar scalar-field solution, which was recently found numerically by Brady {\it et al.} (2002 {\it Class. Quantum. Grav.} {\bf 19} 6359), is also unstable. Both the flat Friedmann universe with a scalar field and that with a stiff fluid suffer from kink instability at the particle horizon scale.Comment: 15 pages, accepted for publication in Classical and Quantum Gravity, typos correcte

An atlas of CO2 storage potential in the nearshore waters of the Texas coast – American Recovery and Reinvestment Act – “Gulf of Mexico Miocene CO2 site characterization mega-transect”

Bureau of Economic Geolog

Harbor Surging

[no abstract

The Anarchical Society At 40: Contemporary Challenges and Prospects

Hedley Bull’s The Anarchical Society was published in 1977. Though considered as one of the classics in International Relations, it does not address many world political issues that concern us deeply today—volatile great power relations after the end of the Cold War, the rise of terrorism, financial crises, climate change, the impact of the Internet, deep-rooted racial inequalities, violence against women. Moreover, through the evolution of International Relations as an academic pursuit, various limitations of the type of approach followed by Bull are coming to light. Against this background, eighteen contributors to this collection, with diverse intellectual orientations and academic specializations, have revisited Bull’s book forty years on to assess its limitations and resilience. A number of contributors point to certain fundamental problems stemming from Bull’s a historical conceptual theorizing. However, several others find arguments and insights developed or hidden in his text which are still relevant, in some cases, highly so, to understanding contemporary world politics while others explore ways of augmenting Bull’s intellectual repertoire. An intricate tapestry of ideas emerges from the criss-crossing contributions to the volume and, through this, it becomes clear that there is more to The Anarchical Society than the ‘international society’ perspective with which it is conventionally associated. The contemporary relevance of Bull’s work is clearest when we recognize the flexibility of his conceptual framework and, in particular, the often overlooked potential of his concept of the ‘world political system’ of which, Bull acknowledges, modern international society is only a part

Formation of primordial black holes from non-Gaussian perturbations produced in a waterfall transition

We consider the process of primordial black hole (PBH) formation originated from primordial curvature perturbations produced during waterfall transition (with tachyonic instability), at the end of hybrid inflation. It is known that in such inflation models, rather large values of curvature perturbation amplitudes can be reached, which can potentially cause a significant PBH production in the early Universe. The probability distributions of density perturbation amplitudes in this case can be strongly non-Gaussian, which requires a special treatment. We calculated PBH abundances and PBH mass spectra for the model, and analyzed their dependence on model parameters. We obtained the constraints on the parameters of the inflationary potential, using the available limits on $\beta_{PBH}$.Comment: v2: 11 pages, 4 figures. Several comments and references added. Version accepted by Phys. Rev.