2,406 research outputs found

    Infrared radiation measurements of combustion gases third quarterly progress report, 1 jan. - 31 mar. 1965

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    Infrared absorption spectrum measurements of carbon monoxide - exhaust gase

    Role of Glutathione in the Regulation of Cisplatin Resistance in Cancer Chemotherapy

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    Three mechanisms have been proposed for the role of glutathione (GSH) in regulating cisplatin (CDDP) sensitivities that affects its ultimate cell-killing ability: (i) GSH may serve as a cofactor in facilitating multidrug resistance protein 2- (MRP2-) mediated CDDP efflux in mammalian cells, since MRP2-transfected cells were shown to confer CDDP resistance; (ii) GSH may serve as a redox-regulating cytoprotector based on the observations that many CDDP-resistant cells overexpress GSH and γ-glutamylcysteine synthesis (γ-GCS), the rate-limiting enzyme for GSH biosynthesis; (iii) GSH may function as a copper (Cu) chelator. Elevated GSH expression depletes the cellular bioavailable Cu pool, resulting in upregulation of the high-affinity Cu transporter (hCtr1) which is also a CDDP transporter. This has been demonstrated that overexpression of GSH by transfection with γ-GCS conferred sensitization to CDDP toxicity. This review describes how these three models were developed and critically reviews their importance to overall CDDP cytotoxicity in cancer cell treatments

    Mate choice promotes inbreeding avoidance in the two-spotted spider mite

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    Since inbreeding in Tetranychus urticae can reduce offspring fitness, sexual selection may favour disassortative mate choice with respect to relatedness of the mating partners. We tested whether T. urticae shows this preference for mating with unrelated partners. We chose an experimental set-up with high potential for female choosiness, since females only mate once and are therefore expected to be the choosier gender. An adult virgin female was placed together with two adult males from the same population. One male was unrelated and the other male was related—a brother with whom she had grown up. Significantly more copulations (64%) took place with the unrelated male. Time to mating did not depend on the female-to-male relatedness. The remaining (non-copulating) male tried to interfere with the ongoing mating in the majority of cases, but this interference did not depend on the female-to-male relatedness. These results imply that T. urticae (a) can recognize kin (via genetic and/or environmental similarity) and (b) has the potential to avoid inbreeding through mate choice

    Stability of Chaplygin gas thin-shell wormholes

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    In this paper we construct spherical thin-shell wormholes supported by a Chaplygin gas. For a rather general class of geometries we introduce a new approach for the stability analysis of static solutions under perturbations preserving the symmetry. We apply this to wormholes constructed from Schwarzschild, Schwarzschild-de Sitter, Schwarzschild-anti de Sitter and Reissner-Nordstrom metrics. In the last two cases, we find that there are values of the parameters for which stable static solutions exist.Comment: 14 pages, 5 figures; v2: minor changes and new references added. Accepted for publication in Physical Review

    Discrete Model of Ideological Struggle Accounting for Migration

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    A discrete in time model of ideological competition is formulated taking into account population migration. The model is based on interactions between global populations of non-believers and followers of different ideologies. The complex dynamics of the attracting manifolds is investigated. Conversion from one ideology to another by means of (i) mass media influence and (ii) interpersonal relations is considered. Moreover a different birth rate is assumed for different ideologies, the rate being assumed to be positive for the reference population, made of initially non-believers. Ideological competition can happen in one or several regions in space. In the latter case, migration of non-believers and adepts is allowed; this leads to an enrichment of the ideological dynamics. Finally, the current ideological situation in the Arab countries and China is commented upon from the point of view of the presently developed mathematical model. The massive forced conversion by Ottoman Turks in the Balkans is briefly discussed.Comment: 24 pages, with 5 figures and 52 refs.; prepared for a Special issue of Advances in Complex System

    Measurement in Quantum Physics

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    The conceptual problems in quantum mechanics -- related to the collapse of the wave function, the particle-wave duality, the meaning of measurement -- arise from the need to ascribe particle character to the wave function. As will be shown, all these problems dissolve when working instead with quantum fields, which have both wave and particle character. Otherwise the predictions of quantum physics, including Bell's inequalities, coincide with those of the standard treatments. The transfer of the results of the quantum measurement to the classical realm is also discussed.Comment: 34 pages, in Latex, revised and expanded version with an extra appendix on decoherenc
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