Evolution of the Dust Coma in Comet 67P/Churyumov-Gerasimenko Before 2009 Perihelion

Comet 67P/Churyumov-Gerasimenko is the main target of ESA's Rosetta mission and will be encountered in May 2014. As the spacecraft shall be in orbit the comet nucleus before and after release of the lander {\it Philae}, it is necessary necessary to know the conditions in the coma. Study the dust environment, including the dust production rate and its variations along its preperihelion orbit. The comet was observed during its approach to the Sun on four epochs between early-June 2008 and mid-January 2009, over a large range of heliocentric distances that will be covered by the mission in 2014. An anomalous enhancement of the coma dust density was measured towards the comet nucleus. The scalelength of this enhancement increased with decreasing heliocentric distance of the comet. This is interpreted as a result of an unusually slow expansion of the dust coma. Assuming a spherical symmetric coma, the average amount of dust as well as its ejection velocity have been derived. The latter increases exponentially with decreasing heliocentric distance (\rh), ranging from about 1 m/s at 3 AU to about 25-35 m/s at 1.4 AU. Based on these results we describe the dust environment at those nucleocentric distances at which the spacecraft will presumably be in orbit. Astronomy and Astrophysics, in pressComment: 5 pages, 4 figure

Acidic Extracellular pH Promotes Activation of Integrin αvβ3

Acidic extracellular pH is characteristic of the cell microenvironment in several important physiological and pathological contexts. Although it is well established that acidic extracellular pH can have profound effects on processes such as cell adhesion and migration, the underlying molecular mechanisms are largely unknown. Integrin receptors physically connect cells to the extracellular matrix, and are thus likely to modulate cell responses to extracellular conditions. Here, we examine the role of acidic extracellular pH in regulating activation of integrin [alpha]v[beta]3. Through computational molecular dynamics simulations, we find that acidic extracellular pH promotes opening of the [alpha]v[beta]3 headpiece, indicating that acidic pH can thereby facilitate integrin activation. This prediction is consistent with our flow cytometry and atomic force microscope-mediated force spectroscopy assays of integrin [alpha]v[beta]3 on live cells, which both demonstrate that acidic pH promotes activation at the intact cell surface. Finally, quantification of cell morphology and migration measurements shows that acidic extracellular pH affects cell behavior in a manner that is consistent with increased integrin activation. Taken together, these computational and experimental results suggest a new and complementary mechanism of integrin activation regulation, with associated implications for cell adhesion and migration in regions of altered pH that are relevant to wound healing and cancer.National Institute of Biomedical Imaging and Bioengineering (U.S.) (Award Number T32EB006348)Massachusetts Institute of Technology (Collamore-Rogers Fellowship)National Institutes of Health (U.S.) (NIH Cell Migration Consortium Grant U54-GM069668)National Science Foundation (U.S.) (CAREER Award)Singapore-MIT Alliance for Research and Technology (BioSystem and Micromechanics (BioSyM) Interdisciplinary Research Group

Characterization of stardust target comet 81P/Wild 2 from 1996 to 1998

We present the results of our monitoring of comet 81P/Wild 2, the target of the STARDUST mission. Broad-band filter images and medium resolution spectra of this comet obtained along its pre- and postperihelion orbit between 1996 and 1998 were analysed in terms of coma morphology and activity. The morphological coma investigation revealed the presence of long-lasting fan structures, which remained essentially unchanged for at least three months. The (B-V) and (V-R) colour indices were determined at three different positions along the orbit. The two-dimensional analysis showed a uniform colour over the entire coma. Hence, the material composing the structures is not different from that of the underlying coma. The distribution of coma brightness as a function of projected distance from the nucleus shows no peculiarities. The evolution of the comet's activity during the pre- and postperihelion phase appears to be asymmetric in that activity increases faster preperihelion than it decreases postperihelion. The production rates (or their upper limits in the case on a non-detection) of CN, C2, C3, and NH2 were determined from the spectrophotometric observations and compared to other values published in the literature. based on observations obtained at ESO La Silla within ESO programmes No. 57.F-0290, 58.F-0413, 58.F-0431 and 60.F-0266