Pengaruh Aktivitas Shalat terhadap Kontrol Glikemik Penderita DM Tipe 2 di Wilayah Kerja Dinas Kesehatan Kabupaten Kuningan

Type 2 Diabetes mellitus (DM) is a chronic disease of carbohydrate, fat, and protein metabolism disorders, which is characterized by elevated chronic blood glucose (hyperglycemia) levels. The sustainable hyperglycemia is able to cause disruption of the entire system of body. This research aimed at finding out the influence of the five-time prayer implementation on the decrease of fasting blood glucose level of type 2 diabetes mellitus. The study employed a quasi experimental research by one group pre and post test design without control group. The number of samples of 15 respondents was determined by purposive sampling technique. The result of statistical analysis showed that there was the significant influence between the five-time prayer implementation and the decrease of fasting blood glucose, the average decrease was 93,113 and p value=0,000. The decrease in fasting blood glucose after the intervention of prayer activity in the form of the implementation of five-day prayers for 3 days caused by the body's physiological effects enhanced GLUT 4 translocation and increase the psychological effects of mind relaxation that occurred during the five-time prayer practic

Prenylated Dihydrostilbenes From Macaranga rubiginosa

Phytochemical isolation of the methanol extract of Macaranga rubiginosa leaves afforded five prenylated dihydrostilbenes. Two of them were known dihydrostilbenes laevifolins A (1) and B (2), while the other three were new compounds, trivially named macarubiginosins A–C (3–5). The structures of the new compounds were elucidated based on their UV, 1D and 2D NMR, and HR-ESI-MS spectral data. Compounds 1–5 were tested for their cytotoxicity against P-388 cells, showing that compound 1 was the most active with IC 50 4.3 µM

Efektifitas Foot Care Education terhadap Praktik Perawatan Kaki dalam Upaya Pencegahan Risiko Ulkus Kaki Diabetik pada Penderita Diabetes di Wilayah Kabupaten Kuningan

Kejadian ulkus kaki diabetik memiliki kecenderungan mengalami peningkatan seiring dengan meningkatnya diabetisi dan sering kali berakhir dengan kecacatan dan kematian. Kabupaten Kuningan menempatkan diabetes pada urutan pertama penyakit yang paling banyak menjalani perawatan inap di Rumah Sakit dengan jumlah kasus 968 penderita pada tahun 2015. Penelitian ini bertujuan untuk mengetahui efektifitas foot care education terhadap perbaikan praktik perawatan kaki dalam upaya pencegahan ulkus kaki diabetik pada diabetisi di Wilayah Kabupaten Kuningan. Penelitian ini menggunakan 2 jenis rancangan penelitian yakni cross sectional dan quasi experimental yang melibatkan 317 diabetisi (cross sectional) dan 220 diabetisi yang tidak pernah mendapatkan informasi tentang perawatan kaki (quasi experimental) sebagai sampel. Hasil penelitian ini adalah (1) status foot care education merupakan faktor yang memiliki hubungan yang signifikan dengan praktik perawatan kaki diabetisi dan perkembangan risiko ulkus kaki dengan p-value 0,01; 0,02 (Chi Square Test). (2) Terdapat perbedaan status praktik perawatan kaki yang signifikan antara kelompok intervensi dan kelompok kontrol pada posttest dengan p-value 0,000 < ? 0,05 (Mann Whitney U Test). Dengan hasil ini, diharapkan pelayanan edukasi perawatan kaki pada tatanan pelayanan kesehatan dapat dioptimalkan guna meningkatkan praktik perawatan kaki oleh diabetisi untuk mencegah terjadinya komplikasi ulkus kaki terutama pada mereka yang berisiko tinggi

Evidence of Inter- and Intra-Molecular Crosslinking of Tyrosine Residues of Calmodulin Induced by Photo-Activation of Ruthenium(II)

Tris(2,2′-bipyridyl)ruthenium(II) upon illumination with light at a wavelength of 450 nm in the presence of an electron acceptor induces dityrosine crosslinking in proteins

Modeling of bioenergy impact on food security of EU countries

Ensuring the energy and food independence of each state will not only remain important but that its importance will continue to grow given the constant need for the state to properly guarantee the basic needs of the population. However, the rapid development of bioenergy is a potential precondition for the fuel and food conflict over agricultural raw materials. The article examines the relationship between food safety indices and the overall share of energy from renewable sources and bioenergy production in 13 European countries. The main factors characterizing the food security of these countries for the period from 2012 to 2018 are identified. Statistical methods of correlation analysis are used to determine the links between the outlined factors. It is studied that in most countries the prosperity of the bioenergy sector of agricultural enterprises does not affect the main indices of food security. In 5 countries (Poland, Germany, Norway, Spain, the Czech Republic) correlations were found, but for the most part, they are direct. It means that large values of one variable are associated with large values of the other, in other words with increasing the share of bioenergy production and overall share of energy from renewable sources, food safety indices also increase

Dihydroflavonol and Flavonol Derivatives from Macaranga recurvata

Two new dihydroflavonol derivatives, macarecurvatins A and B, have been isolated from the leaves of Macaranga recurvata (Euphorbiaceaae), along with the known compounds diisoprenylaromadendrin, glyasperin A and broussoflavonol F. The structures of the new compounds were determined on the basis of of 0.83 M. spectroscopic evidence. Upon cytotoxic evaluation against P-388 cells, macarecurvatin B showed strong activity with an IC 5

Flavonoid and stilbene derivatives from Macaranga trichocarpa

A new farnesylated flavonol (4′-O-methylmacagigantin) and a new geranylated stilbene (macatrichocarpin H), together with eight known phenolic compounds, have been isolated from the leaves of Macaranga trichocarpa. Structures of these compounds were determined based on NMR and mass spectrroscopic data. Cytotoxic properties of the isolated compounds were tested against P-388 cells showing that mactrichocarpin G was the most active compound with IC 50 was 3.5 μM