Antibacterial activity of the five South African Erythroxylaceae species

Until recently, no medicinal uses were recorded for the South African Erythroxylaceae species, although, this family is used world wide in traditional medicine. This study reveals for the first time that Erythroxylum delagoense and Erythroxylum pictum roots were used to treat dysentery and diarrhoea and that Erythroxylum emarginatum leaves decoction was used to treat asthma, kidney problems, arthritis, child bearing problems and influenza in South Africa. To validate some of the medicinal uses, antibacterial testing was done for the first time on all five South African species. Leaf and bark extracts of four of the five South African Erythroxylaceae species (E. delagoense, E. emarginatum, E. pictum and Nectaropetalum capense) showed some good antibacterial activities with MIC <1 mg/ml. E. delagoense showed good results against Bacillus subtilis, Klebsiella pneumoniae and Staphylococcus aureus; E. emarginatum against Klebsiella pneumoniae; E. pictum against Bacillus subtilis and Klebsiella pneumonia; N. capense against Klebsiella pneumonia.Key words: Antimicrobial activity, Erythroxylaceae, medicinal uses, South Africa

'N vergelykende studie van vismeel, sonneblomoliekoekmeel en formaldehiedbehandelde sonneblomoliekoekmeel as proteïen supplemente vir skape

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Prevalence of hearing loss at primary health care clinics in South Africa

Background: Hearing loss prevalence data in South Africa is scarce, especially within primary health care settings. Objectives: To determine; (i) the prevalence of hearing disorders in patients ≥3 years of age attending two primary health care clinics, and (ii) the nature and characteristics of hearing disorders at these primary health care clinics. Method: A cross-sectional design was used at two primary health care clinics. Non-probability purposive sampling was used to screen participants at clinics for hearing loss with pure tone audiometry. A total of 1236 participants were screened (mean age 37.8 ±17.9 years). Diagnostic testing was available for confirmation of hearing loss on participants who failed the screening. Results: Hearing loss prevalence was 17.5% across both clinics. Most hearing losses were bilateral (70.0%) and were of a sensorineural nature (84.2%). Conclusion: Hearing loss prevalence was comparable at both primary health care clinics. Participants 40 years and older were at significantly higher risk for hearing loss. The current study is the first attempt to establish hearing loss prevalence for primary health care clinics in South Africa.Keywords: Hearing loss, primary health care clinics, South Africa

Applying the trigger review method after a brief educational intervention: potential for teaching and improving safety in GP specialty training?

<p>Background: The Trigger Review Method (TRM) is a structured approach to screening clinical records for undetected patient safety incidents (PSIs) and identifying learning and improvement opportunities. In Scotland, TRM participation can inform GP appraisal and has been included as a core component of the national primary care patient safety programme that was launched in March 2013. However, the clinical workforce needs up-skilled and the potential of TRM in GP training has yet to be tested. Current TRM training utilizes a workplace face-to-face session by a GP expert, which is not feasible. A less costly, more sustainable educational intervention is necessary to build capability at scale. We aimed to determine the feasibility and impact of TRM and a related training intervention in GP training.</p> Methods We recruited 25 west of Scotland GP trainees to attend a 2-hour TRM workshop. Trainees then applied TRM to 25 clinical records and returned findings within 4-weeks. A follow-up feedback workshop was held. <p>Results: 21/25 trainees (84%) completed the task. 520 records yielded 80 undetected PSIs (15.4%). 36/80 were judged potentially preventable (45%) with 35/80 classified as causing moderate to severe harm (44%). Trainees described a range of potential learning and improvement plans. Training was positively received and appeared to be successful given these findings. TRM was valued as a safety improvement tool by most participants.</p> <p>Conclusion: This small study provides further evidence of TRM utility and how to teach it pragmatically. TRM is of potential value in GP patient safety curriculum delivery and preparing trainees for future safety improvement expectations.</p&gt

Paediatric trauma care

Paediatric trauma care varies in different countries. In South Africa injury is the leading cause of death in the 5 - 14-yearold age group - 1,5 - 3,8 times higher than in the USA. In 1978 the Child Safety Centre was established and prospectively collected data on paediatric injuries. The various types of injuries are discussed. Trauma is responsible for the highest percentage of years of life lost but the least amount of money is being spent on research and prevention of injuries. The Child Accident Prevention Foundation of Southern Africa has been constituted to research, prevent and reduce the risk factors of the injuries and to improve facilities for the injured child

International survey of audiologists' attitudes toward telehealth

PURPOSE : A better understanding of the attitudes of audiologists toward teleaudiology and their willingness to use teleaudiology is required to progress the application of teleaudiology technologies and services into clinical practice. Audiologists around the world were surveyed on their attitudes toward teleaudiology and their willingness to use it. METHOD : An online survey was sent to audiologists through professional associations' mailing lists. The survey included questions on the use of computer and video-conferencing technologies, awareness and previous use of teleaudiology, and willingness to use teleaudiology. RESULTS : Responses were provided by 269 people from 28 different countries, representing a wide cross-section of experience, qualification, and work settings; 77.8% of respondents were women. Almost all respondents had used PC-based video-conferencing; most had used related technologies and reported positive attitudes toward using these. However, less than 25% had used teleaudiology. CONCLUSIONS : Despite positive attitudes toward telehealth and associated technology, the low number of audiologists who have used teleaudiology for services indicates limited clinical adoption.Portions of this work were presented at the Second International Meeting on Internet & Audiology, Snekkersten, Denmark (September 2015).http://aja.pubs.asha.org/Speech-Language Pathology and Audiolog

Chemical Changes of Flattened Enamel Surfaces with in Vitro Weak Acid Demineralization

Infrared internal reflection spectroscopy (IRS) was used to study changes in surface chemistry of enamel after in vitro weak acid demineralization. Hypotheses that relate previous histomorphologic observations to current IRS findings are discussed.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68276/2/10.1177_00220345710500064001.pd

Identification of depression in a rural general practice

Major depression is underdiagnosed by general practitioners, but the reasons for this are not clear. This study aimed to establish the prevalence of major depression and coexisting generalised anxiety disorder in a rural general practice in the Orange Free State. It also assessed the predictive value of a screening questionnaire for use by general practitioners. The two practitioners evaluated 858 patients over a 4-week period. Those who met the screening criteria, together with a random sample of 60 patients who did not, were re-evaluated by a registrar in psychiatry who was unaware of the findings of his colleagues. Of the patients studied, 134 (15,6%) had major depression; 59 of these (44,0%) also had coexisting generalised anxiety disorder. The general practitioners had . correctly diagnosed major depression in 32 patients (3,7%) before the study started. The screening questionnaire had a 42% chance of correctly identifying a patient with depression and a 97% chance of correctly identifying a patient who did not have major depression. Both practitioners were equally capable at identifying major depression. The study confirmed both the high prevalence of depression in a rural general practice and its low identification rate. It also showed the advantage of using a screening questionnaire to alert practitioners to the possibility of depression in their patients

Intact Polar brGDGTs in Arctic Lake Catchments: Implications for Lipid Sources and Paleoclimate Applications

Paleotemperature histories derived from lake sediment archives provide valuable context for modern and future climate changes. Branched glycerol dialkyl glycerol tetraether (brGDGT) lipids are a valuable tool in such pursuits due to their empirical correlation with temperature and near ubiquity in nature. However, the relative contributions of terrestrial and lacustrine sources of brGDGTs to lake sediments is site-dependent and difficult to constrain. Here, we explored the potential for intact brGDGTs—the complete lipids with polar head groups (HGs) still attached—to provide insight into the sources of brGDGTs on the landscape and their contributions to the sedimentary record in a set of Arctic lakes. We measured core and intact brGDGTs in soils, surface and downcore sediments, water filtrates, and sediment traps across five lake catchments in the Eastern Canadian Arctic, with an emphasis on Lake Qaupat (QPT), Baffin Island. Soils were dominated by brGDGTs with a monoglycosyl (1G) HG, while lacustrine samples contained more phosphohexose (PH) brGDGTs, providing evidence for in situ brGDGT production in both settings. Core- and PH-brGDGT-IIIa were more abundant in sediments than in the soils or water column, implying an additional post-depositional source of brGDGTs. A hierarchical clustering analysis indicated that core brGDGTs in Lake QPT sediments were largely lacustrine in origin, while 1G-brGDGTs were primarily soil-derived. Additionally, we found evidence for preservation of intact brGDGTs—especially 1G-brGDGTs—downcore on thousand-year timespans, though in situ production deeper in the sediment column cannot be ruled out. Finally, we explored the possibility of reconstructing 1G-brGDGT-derived soil temperatures and core-brGDGT-derived lake temperatures in tandem from sedimentary archives