Two-dimensional, Time-dependent, Multi-group, Multi-angle Radiation Hydrodynamics Test Simulation in the Core-Collapse Supernova Context

We have developed a time-dependent, multi-energy-group, and multi-angle (S$_n$) Boltzmann transport scheme for radiation hydrodynamics simulations, in one and two spatial dimensions. The implicit transport is coupled to both 1D (spherically-symmetric) and 2D (axially-symmetric) versions of the explicit Newtonian hydrodynamics code VULCAN. The 2D variant, VULCAN/2D, can be operated in general structured or unstructured grids and though the code can address many problems in astrophysics it was constructed specifically to study the core-collapse supernova problem. Furthermore, VULCAN/2D can simulate the radiation/hydrodynamic evolution of differentially rotating bodies. We summarize the equations solved and methods incorporated into the algorithm and present results of a time-dependent 2D test calculation. A more complete description of the algorithm is postponed to another paper. We highlight a 2D test run that follows for 22 milliseconds the immediate post-bounce evolution of a collapsed core. We present the relationship between the anisotropies of the overturning matter field and the distribution of the corresponding flux vectors, as a function of energy group. This is the first 2D multi-group, multi-angle, time-dependent radiation/hydro calculation ever performed in core collapse studies. Though the transport module of the code is not gray and does not use flux limiters (however, there is a flux-limited variant of VULCAN/2D), it still does not include energy redistribution and most velocity-dependent terms.Comment: 19 pages, plus 13 figures in JPEG format. Submitted to the Astrophysical Journa

A critique of the evidence for active host defence against cancer, based on personal studies of 27 murine tumours of spontaneous origin.

Extensive experience with isotransplants of 27 different tumours (leukaemias, sarcomata, carcinomata), all of strictly spontaneous origin in laboratory bred mice of low cancer strains CBA/Ht and WHT/Ht, has revealed no evidence of tumour immunogenicity. Of approximately 20,000 maintenance transplants, none failed and none regressed; of almost 10,000 carefully observed tumours arising from small or minimal inocula of tumour cells, none spontaneously regressed. The number of injected viable tumour cells required to give a 50% probability of successful transplantation (the TD50) ranged from approximately 1 cell to greater than 10,000 cells among the 27 tumours; high TD50 values, which were dramatically reduced by various procedures having no immunological significance, did not signify active "resistance" of the hosts. In the case of all of 7 randomly selected tumours, prior "immunization" of recipients with homologous lethally irradiated cells increased their tumour receptivity. Several experiments using various tumours failed to give evidence that immunity could be non-specifically induced or that a massive preponderance of lymphocytes from specifically sensitized mice could inhibit tumour transplantation or growth in vivo; no trace of "resistance" to tumour was adopted by isogeneic recipients of lymphocytes from regional nodes of tumour bearers. A limited review of the recent literature on tumour immunity shows that practically all the animal data presented in support of a general theory of tumour immunogenicity or to provide a basis for active clinical immunotherapy have been obtained from transplanted tumour systems which entail artefactual immunity associated with viral or chemical induction of the tumours or their allogeneic transplantation. It is suggested that isotransplants of spontaneously arising tumours are the only appropriate models of human cancer and that any genuine rapport between the animal laboratory and the clinic requires their exclusive use

Gravitational Waves from Axisymmetric, Rotational Stellar Core Collapse

We have carried out an extensive set of two-dimensional, axisymmetric, purely-hydrodynamic calculations of rotational stellar core collapse with a realistic, finite-temperature nuclear equation of state and realistic massive star progenitor models. For each of the total number of 72 different simulations we performed, the gravitational wave signature was extracted via the quadrupole formula in the slow-motion, weak-field approximation. We investigate the consequences of variation in the initial ratio of rotational kinetic energy to gravitational potential energy and in the initial degree of differential rotation. Furthermore, we include in our model suite progenitors from recent evolutionary calculations that take into account the effects of rotation and magnetic torques. For each model, we calculate gravitational radiation wave forms, characteristic wave strain spectra, energy spectra, final rotational profiles, and total radiated energy. In addition, we compare our model signals with the anticipated sensitivities of the 1st- and 2nd-generation LIGO detectors coming on line. We find that most of our models are detectable by LIGO from anywhere in the Milky Way.Comment: 13 pages, 22 figures, accepted for publication in ApJ (v600, Jan. 2004). Revised version: Corrected typos and minor mistakes in text and references. Minor additions to the text according to the referee's suggestions, conclusions unchange

Marxism, Maoism, and Social Change

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68502/2/10.1177_009770047700300201.pd

Light-to-light readout system of the CMS electromagnetic calorimeter

For the Compact Muon Solenoid (CMS) experiment at the Large Hadron Collider (LHC) at CERN, an 80,000-crystal electromagnetic calorimeter will measure electron and photon energies with high precision over a dynamic range of roughly 16 bits. The readout electronics will be located directly behind the crystals, and must survive a total dose of up to 2×104 Gy along with 5×1013 n/cm 2. A readout chain consisting of a custom wide-range acquisition circuit, commercial ADC and custom optical link for each crystal is presently under construction. An overview of the design is presented, with emphasis on the large-scale fiber communication syste

Anisotropies in the Neutrino Fluxes and Heating Profiles in Two-dimensional, Time-dependent, Multi-group Radiation Hydrodynamics Simulations of Rotating Core-Collapse Supernovae

Using the 2D multi-group, flux-limited diffusion version of the code VULCAN/2D, that also incorporates rotation, we have calculated the collapse, bounce, shock formation, and early post-bounce evolutionary phases of a core-collapse supernova for a variety of initial rotation rates. This is the first series of such multi-group calculations undertaken in supernova theory with fully multi-D tools. We find that though rotation generates pole-to-equator angular anisotropies in the neutrino radiation fields, the magnitude of the asymmetries is not as large as previously estimated. Moreover, we find that the radiation field is always more spherically symmetric than the matter distribution, with its plumes and convective eddies. We present the dependence of the angular anisotropy of the neutrino fields on neutrino species, neutrino energy, and initial rotation rate. Only for our most rapidly rotating model do we start to see qualitatively different hydrodynamics, but for the lower rates consistent with the pre-collapse rotational profiles derived in the literature the anisotropies, though interesting, are modest. This does not mean that rotation does not play a key role in supernova dynamics. The decrease in the effective gravity due to the centripetal effect can be quite important. Rather, it means that when a realistic mapping between initial and final rotational profiles and 2D multi-group radiation-hydrodynamics are incorporated into collapse simulations the anisotropy of the radiation fields may be only a secondary, not a pivotal factor, in the supernova mechanism.Comment: Includes 11 low-resolution color figures, accepted to the Astrophysical Journal (June 10, 2005; V. 626); high-resolution figures and movies available from the authors upon reques

Silver fir (Abies alba Mill.) is able to thrive and prosper under meso-Mediterranean conditions

The potential ecological envelope of silver fir (Abies alba Mill.) based on its present distribution suggests a high suitability for moist rather than warm and dry environments. This contrasts with paleoecological evidence reporting its former presence at low elevations under meso-Mediterranean conditions. In this study, we evaluated the growth performance of silver fir at low elevation (20–60 m a.s.l.) under meso-Mediterranean climatic conditions in Tuscany (central Italy). We conducted a dendroecological analysis on Abies alba trees along a geomorphological gradient (from depression to upper slope conditions). Climate-growth relationships were assessed by means of correlations, response functions, pointer years, and superposed epoch analysis. Silver fir was found to grow and regenerate well in these stands mixed with evergreen (e.g., Quercus ilex L.) and thermophilous deciduous Mediterranean tree species (e.g., Q. cerris L.). Summer drought was the most growth-influencing factor, with immediate (i.e., current season) negative impacts on tree-ring widths (TRW). No significant impacts were observed in the four years following extreme summer droughts, but the TRW series (which started between the 1930s and 1950s) showed a growth decline since the mid-1990s that is likely drought-related. Our results show that, provided there is a sufficiently large soil water holding capacity, silver fir provenances exist which are able to withstand Mediterranean summer droughts, can naturally and regularly regenerate in these systems, and may even dominate over typical meso-Mediterranean species. As long as annual precipitation is not too low (i.e., >850 mm) and summer drought conditions not too extreme (i.e., less than three months), silver fir has thus the potential to thrive under warm Mediterranean conditions.ISSN:0378-1127ISSN:1872-704

Association of differential gene expression with imatinib mesylate and omacetaxine mepesuccinate toxicity in lymphoblastoid cell lines

BackgroundImatinib mesylate is currently the drug of choice to treat chronic myeloid leukemia. However, patient resistance and cytotoxicity make secondary lines of treatment, such as omacetaxine mepesuccinate, a necessity. Given that drug cytotoxicity represents a major problem during treatment, it is essential to understand the biological pathways affected to better predict poor drug response and prioritize a treatment regime.MethodsWe conducted cell viability and gene expression assays to determine heritability and gene expression changes associated with imatinib and omacetaxine treatment of 55 non-cancerous lymphoblastoid cell lines, derived from 17 pedigrees. In total, 48,803 transcripts derived from Illumina Human WG-6 BeadChips were analyzed for each sample using SOLAR, whilst correcting for kinship structure.ResultsCytotoxicity within cell lines was highly heritable following imatinib treatment (h2&thinsp;=&thinsp;0.60-0.73), but not omacetaxine treatment. Cell lines treated with an IC20 dose of imatinib or omacetaxine showed differential gene expression for 956 (1.96%) and 3,892 transcripts (7.97%), respectively; 395 of these (0.8%) were significantly influenced by both imatinib and omacetaxine treatment. k-means clustering and DAVID functional annotation showed expression changes in genes related to kinase binding and vacuole-related functions following imatinib treatment, whilst expression changes in genes related to cell division and apoptosis were evident following treatment with omacetaxine. The enrichment scores for these ontologies were very high (mostly &gt;10).ConclusionsInduction of gene expression changes related to different pathways following imatinib and omacetaxine treatment suggests that the cytotoxicity of such drugs may be differentially tolerated by individuals based on their genetic background.<br /

An Exact Integration Scheme for Radiative Cooling in Hydrodynamical Simulations

A new scheme for incorporating radiative cooling in hydrodynamical codes is presented, centered around exact integration of the governing semi-discrete cooling equation. Using benchmark calculations based on the cooling downstream of a radiative shock, I demonstrate that the new scheme outperforms traditional explicit and implicit approaches in terms of accuracy, while remaining competitive in terms of execution speed.Comment: 7 pages, accepted by ApJS. Revision 2, with error in eqn. 13 fixe