A theoretical study of microwave beam absorption by a rectenna

The rectenna's microwave power beam absorption limit was theoretically confirmed by two mathematical models descriptive of the microwave absorption process; first one model was based on the current sheet equivalency of a large planar array above a reflector and the second model, which was based on the properties of a waveguide with special imaging characteristics, quantified the electromagnetic modes (field configurations) in the immediate vicinity of a Rectenna element spacing which permit total power beam absorption by preventing unwanted modes from propagating (scattering) were derived using these models. Several factors causing unwanted scattering are discussed

alpha-Synuclein promotes dilation of the exocytotic fusion pore

The protein α-synuclein has a central role in the pathogenesis of Parkinson's disease. Like that of other proteins that accumulate in neurodegenerative disease, however, the function of α-synuclein remains unknown. Localization to the nerve terminal suggests a role in neurotransmitter release, and overexpression inhibits regulated exocytosis, but previous work has failed to identify a clear physiological defect in mice lacking all three synuclein isoforms. Using adrenal chromaffin cells and neurons, we now find that both overexpressed and endogenous synuclein accelerate the kinetics of individual exocytotic events, promoting cargo discharge and reducing pore closure ('kiss-and-run'). Thus, synuclein exerts dose-dependent effects on dilation of the exocytotic fusion pore. Remarkably, mutations that cause Parkinson's disease abrogate this property of α-synuclein without impairing its ability to inhibit exocytosis when overexpressed, indicating a selective defect in normal function

Activation of nonselective cation channels by physiological cholecystokinin concentrations in mouse pancreatic acinar cells

The activation of the nonselective cation channels in mouse pancreatic acinar cells has been assessed at low agonist concentrations using patch-clamp whole cell, cell-attached patch, and isolated inside-out patch recordings. Application of acetylcholine (ACh) (25-1,000 nM) and cholecystokinin (CCK) (2-10 pM) evoked oscillatory responses in both cation and chloride currents measured in whole cell experiments. In cell-attached patch experiments we demonstrate CCK and ACh evoked opening of single 25-pS cation channels in the basolateral membrane. Therefore, at least a component of the whole cell cation current is due to activation of cation channels in the basolateral acinar cell membrane. To further investigate the reported sensitivity of the cation channel to intracellular ATP and calcium we used excised inside-out patches. Micromolar Ca2+ concentrations were required for significant channel activation. Application of ATP and ADP to the intracellular surface of the patch blocked channel opening at concentrations between 0.2 and 4 mM. The nonmetabolizable ATP analogue, 5'- adenylylimidodiphosphate (AMP-PNP, 0.2-2 mM), also effectively blocked channel opening. The subsequent removal of ATP caused a transient increase in channel activity not seen with the removal of ADP or AMP- PNP. Patches isolated into solutions containing 2 mM ATP showed channel activation at micromolar Ca2+ concentrations. Our results show that ATP has two separate effects. The continuous presence of the nucleotide is required for operation of the cation channels and this action seems to depend on ATP hydrolysis. ATP can also close the channel and this effect can be demonstrated in excised inside-out patches when ATP is added to the bath after a period of exposure to an ATP-free solution. This action does not require ATP hydrolysis. Under physiological conditions hormonal stimulation can open the nonselective cation channels and this can be explained by the rise in the intracellular free Ca2+ concentration

String Bit Models for Superstring

We extend the model of string as a polymer of string bits to the case of superstring. We mainly concentrate on type II-B superstring, with some discussion of the obstacles presented by not II-B superstring, together with possible strategies for surmounting them. As with previous work on bosonic string we work within the light-cone gauge. The bit model possesses a good deal less symmetry than the continuous string theory. For one thing, the bit model is formulated as a Galilei invariant theory in $(D-2)+1$ dimensional space-time. This means that Poincar\'e invariance is reduced to the Galilei subgroup in $D-2$ space dimensions. Naturally the supersymmetry present in the bit model is likewise dramatically reduced. Continuous string can arise in the bit models with the formation of infinitely long polymers of string bits. Under the right circumstances (at the critical dimension) these polymers can behave as string moving in $D$ dimensional space-time enjoying the full $N=2$ Poincar\'e supersymmetric dynamics of type II-B superstring.Comment: 43 pages, phyzzx require

1+11+1-Dimensional Large NN QCD coupled to Adjoint Fermions

We consider 1+1-dimensional QCD coupled to Majorana fermions in the adjoint representation of the gauge group $SU(N)$. Pair creation of partons (fermion quanta) is not suppressed in the large-$N$ limit, where the glueball-like bound states become free. In this limit the spectrum is given by a linear \lc\ Schr\" odinger equation, which we study numerically using the discretized \lcq. We find a discrete spectrum of bound states, with the logarithm of the level density growing approximately linearly with the mass. The wave function of a typical excited state is a complicated mixture of components with different parton numbers. A few low-lying states, however, are surprisingly close to being eigenstates of the parton number, and their masses can be accurately calculated by truncated diagonalizations.Comment: 22 pages + 9 figures (available by request from [email protected]), uses phyzzx.tex + tables.tex PUPT-1413, IASSNS-HEP-93/4

Quantum Newtonian Dynamics on a Light Front

We recall the special features of quantum dynamics on a light-front (in an infinite momentum frame) in string and field theory. The reason this approach is more effective for string than for fields is stressed: the light-front dynamics for string is that of a true Newtonian many particle system, since a string bit has a fixed Newtonian mass. In contrast, each particle of a field theory has a variable Newtonian mass P^+, so the Newtonian analogy actually requires an infinite number of species of elementary Newtonian particles. This complication substantially weakens the value of the Newtonian analogy in applying light-front dynamics to nonperturbative problems. Motivated by the fact that conventional field theories can be obtained as infinite tension limits of string theories, we propose a way to recast field theory as a standard Newtonian system. We devise and analyze some simple quantum mechanical systems that display the essence of the proposal, and we discuss prospects for applying these ideas to large N_c QCD.Comment: 13 pages, 3 figures, LaTex, psfig, references added, APS copyrigh

Qualitative research within trials: developing a standard operating procedure for a clinical trials unit

<p>BACKGROUND: Qualitative research methods are increasingly used within clinical trials to address broader research questions than can be addressed by quantitative methods alone. These methods enable health professionals, service users, and other stakeholders to contribute their views and experiences to evaluation of healthcare treatments, interventions, or policies, and influence the design of trials. Qualitative data often contribute information that is better able to reform policy or influence design.</p> <p>METHODS: Health services researchers, including trialists, clinicians, and qualitative researchers, worked collaboratively to develop a comprehensive portfolio of standard operating procedures (SOPs) for the West Wales Organisation for Rigorous Trials in Health (WWORTH), a clinical trials unit (CTU) at Swansea University, which has recently achieved registration with the UK Clinical Research Collaboration (UKCRC). Although the UKCRC requires a total of 25 SOPs from registered CTUs, WWORTH chose to add an additional qualitative-methods SOP (QM-SOP).</p> <p>RESULTS: The qualitative methods SOP (QM-SOP) defines good practice in designing and implementing qualitative components of trials, while allowing flexibility of approach and method. Its basic principles are that: qualitative researchers should be contributors from the start of trials with qualitative potential; the qualitative component should have clear aims; and the main study publication should report on the qualitative component.</p> <p>CONCLUSIONS: We recommend that CTUs consider developing a QM-SOP to enhance the conduct of quantitative trials by adding qualitative data and analysis. We judge that this improves the value of quantitative trials, and contributes to the future development of multi-method trials.</p&gt