Hybrid cities and new working spaces – The case of Oslo

Recent decades have seen the emergence of hybrid models of living and working associated typologies. These developments have been analysed from the perspective of different disciplines, each with their own interpretation of this phenomenon. Planning and architecture have addressed hybridization as a specific form of interaction between spatio-functional features (such as mixed use, multi-functionality and flexibility) and social features (such as formal and informal interactions and the spontaneous appropriation of spaces) or have sometimes simply focused on the spatio-functional dimension in urban spaces. Studies from other disciplines (e.g. mobility networks, transportation, sociology and information technology) have shown that hybrid spaces cannot exist without access to digitalization technologies. Such technologies are accelerating hybridization processes. This study examines the complex and layered phenomenon of hybridization as a possible combination of (or interaction between) spatio-functional, social and digital features within the planning debate and related fields. Most of the case studies explored by scholars so far have focused on interactions occurring between residential, social and recreational functions, but working functions are playing an increasingly important role. Furthermore, the COVID-19 pandemic has accelerated the development of new forms of hybridity in cities. As a consequence, the rising use of hybrid (on-site and on-line) working practices, planners, policy makers and stakeholders, as well as scholars, have increasingly discussed the concept of hybridization. In this context, various hybrid typologies of urban spaces have materialized in forms such as new working spaces (NWS) which include co-working spaces, incubators, as well as some cafés and multi-functional public libraries, which have recently provided working spaces. This paper focuses on the evolving concept of hybridity from the planning perspective. Based on five hybrid NWS including their surrounding neighbourhoods in Oslo, it provides empirical evidence for an understanding of the phenomenon that may support the development of hybrid spaces and buildings and develops suggestions for planning strategies. © 2022 The Author

In vitro gas production of wheat grain flour coated with different fat types and levels

Gas production (GP) is a rapid method for feedstuffs assessment. A study was done to investigate wheat grain coated with hydrogenated tallow (HT) and hydrogenated palm oil (HP) of different fatty acids types and levels to study total gas production. Approximately, 200 mg (DM basis) of sample was weighed and inserted in glass syringes, mixed with the inoculum and artificial saliva, then incubated at 39°C in a ventilated oven. The outcome of this study showed that experimental fat reduced in vitro degradability using the gas test technique. The addition of experimental fat (HT or HP) to wheat grains significantly decreased GP during incubation (P < 0.01). In comparison to HP fat, coating wheat grains with HT fat resulted in significantly reduced GP (P < 0.01). Accordingly, it seems that experimental fats could be used as a coating substance to reduce the speed of cereal grains (like barley and wheat grains) fermentation in the rumen. Consequently, it could prevent dairy cows from metabolic diseases like acidosis. Moreover, this processing could alter the amount of starch reaching the small intestine to produce more glucose for high producing animals like dairy cows.Key words: Wheat grain, fat coating method, gas production, hydrogenated tallow, hydrogenated palm oil

A fully integrated autonomous power management system with high power capacity and novel MPPT for thermoelectric energy harvesters in IoT/wearable applications

This paper reports a fully integrated autonomous power management system for thermoelectric energy harvesting with application in batteryless IoT/Wearable devices. The novel maximum power point tracking (MPPT) algorithm does not require open circuit voltage measurement. The proposed system delivers 0.5 mA current with 1 V regulated output based on simulations, which is the highest output current for a fully integrated converter reported in the literature for ultra-low voltage applications, to the best knowledge of the authors. Regulated 1 V output can be achieved for load range >2 k Omega, and input voltage range >140 mV. The circuit has been implemented in UMC-180nm standard CMOS technology and simulated

Classical and quantum spinor cosmology with signature change

We study the classical and quantum cosmology of a universe in which the matter source is a massive Dirac spinor field and consider cases where such fields are either free or self-interacting. We focus attention on the spatially flat Robertson-Walker cosmology and classify the solutions of the Einstein-Dirac system in the case of zero, negative and positive cosmological constant $\Lambda$. For $\Lambda<0$, these solutions exhibit signature transitions from a Euclidean to a Lorentzian domain. In the case of massless spinor fields it is found that signature changing solutions do not exist when the field is free while in the case of a self-interacting spinor field such solutions may exist. The resulting quantum cosmology and the corresponding Wheeler-DeWitt equation are also studied for both free and self interacting spinor fields and closed form expressions for the wavefunction of the universe are presented. These solutions suggest a quantization rule for the energy.Comment: 13 pages, 4 figure

Cerebrospinal Fluid Inflammatory Biomarkers Reflect Clinical Severity in Huntington's Disease

INTRODUCTION: Immune system activation is involved in Huntington’s disease (HD) pathogenesis and biomarkers for this process could be relevant to study the disease and characterise the therapeutic response to specific interventions. We aimed to study inflammatory cytokines and microglial markers in the CSF of HD patients. METHODS: CSF TNF-α, IL-1β, IL-6, IL-8, YKL-40, chitotriosidase, total tau and neurofilament light chain (NFL) from 23 mutation carriers and 14 healthy controls were assayed. RESULTS: CSF TNF-α and IL-1β were below the limit of detection. Mutation carriers had higher YKL-40 (p = 0.003), chitotriosidase (p = 0.015) and IL-6 (p = 0.041) than controls. YKL-40 significantly correlated with disease stage (p = 0.007), UHDRS total functional capacity score (r = -0.46, p = 0.016), and UHDRS total motor score (r = 0.59, p = 4.5*10−4) after adjustment for age. CONCLUSION: YKL-40 levels in CSF may, after further study, come to have a role as biomarkers for some aspects of HD. Further investigation is needed to support our exploratory findings

Developing performance indicators for clinical governance in dimensions of risk management and clinical effectiveness

Objective: This study has been designed and conducted to develop domestic indicators for evaluating the performance of clinical governance in dimensions of risk management and clinical effectiveness. Design: This study implemented a 5-stage process including conducting a comprehensive literature review, expert panel (~1000 h per person per session, 11 experts), semi-structured interviews, a 2-round Delphi study (33 experts were in attendance) and a final expert panel (8 experts were in attendance). Setting: East Azerbaijan-Iran Province. Participants: Fifty-six specialists and experts in different fields of medical sciences. Main Outcome Measures: Importance and applicability of indicators. Results: Using a thorough literature review, 361 indicators (129 risk management indicators in 4 dimensions and 232 clinical effectiveness indicators in 18 dimensions) were found. After conducting expert panels and interviews, the number of indicators decreased to 168 cases (65 risk management indicators in 4 dimensions and 103 clinical effectiveness indicators in 12 dimensions). Two rounds of Delphi identified four indicators that were omitted. The members of the final expert panel agreed on 113 indicators (43 risk management indicators in 4 dimensions and 70 clinical effectiveness indicators in 11 dimensions). Conclusion: In this study, indicators for assessing clinical governance in domains of risk management and clinical effectiveness were designed that can be used by policy-makers and other authorities for improving the quality of services and evaluating the performance of clinical governance. Those indicators can be used with slight modifications in other countries having healthcare systems similar to that of Iran. © The Author 2015. Published by Oxford University Press in association with the International Society for Quality in Health Care; all rights reserved

Canonical wave packets in quantum cosmology

We discuss the construction of wave packets resulting from the solutions of a class of Wheeler-DeWitt equations in Robertson-Walker type cosmologies, for arbitrary curvature. We show that there always exists a ``canonical initial slope" for a given initial wave function, which optimizes some desirable properties of the resulting wave packet, most importantly good classical-quantum correspondence. This can be properly denoted as a canonical wave packet. We introduce a general method for finding these canonical initial slopes which is generalization of our earlier work.Comment: 19 pages, 8 figure

Wild-type huntingtin regulates human macrophage function

The huntingtin (HTT) protein in its mutant form is the cause of the inherited neurodegenerative disorder, Huntington\u27s disease. Beyond its effects in the central nervous system, disease-associated mutant HTT causes aberrant phenotypes in myeloid-lineage innate immune system cells, namely monocytes and macrophages. Whether the wild-type form of the protein, however, has a role in normal human macrophage function has not been determined. Here, the effects of lowering the expression of wild-type (wt)HTT on the function of primary monocyte-derived macrophages from healthy, non-disease human subjects were examined. This demonstrated a previously undescribed role for wtHTT in maintaining normal macrophage health and function. Lowered wtHTT expression was associated, for instance, with a diminished release of induced cytokines, elevated phagocytosis and increased vulnerability to cellular stress. These may well occur by mechanisms different to that associated with the mutant form of the protein, given an absence of any effect on the intracellular signalling pathway predominantly associated with macrophage dysfunction in Huntington\u27s disease