Sous-groupes alg\'ebriques du groupe de Cremona

We give a complete classification of maximal algebraic subgroups of the Cremona group of the plane and provide algebraic varieties that parametrize the conjugacy classes. ----- Nous donnons une classification compl\`ete des sous-groupes alg\'ebriques maximaux du groupe de Cremona du plan et explicitons les vari\'et\'es qui param\`etrent les classes de conjugaison.Comment: Text in French, Translated introduction, 35 pages, 1 figure, to appear in Transform. Group

Rational real algebraic models of compact differential surfaces with circle actions

We give an algebro-geometric classification of smooth real affine algebraic surfaces endowed with an effective action of the real algebraic circle group $\mathbb{S}^1$ up to equivariant isomorphisms. As an application, we show that every compact differentiable surface endowed with an action of the circle $S^1$ admits a unique smooth rational real quasi-projective model up to $\mathbb{S}^1$-equivariant birational diffeomorphism

Gpr176 is a Gz-linked orphan G-protein-coupled receptor that sets the pace of circadian behaviour.

体内時計を調節するオーファンGPCRの同定 －生体リズム調整薬の開発に期待－. 京都大学プレスリリース. 2016-02-18.G-protein-coupled receptors (GPCRs) participate in a broad range of physiological functions. A priority for fundamental and clinical research, therefore, is to decipher the function of over 140 remaining orphan GPCRs. The suprachiasmatic nucleus (SCN), the brain's circadian pacemaker, governs daily rhythms in behaviour and physiology. Here we launch the SCN orphan GPCR project to (i) search for murine orphan GPCRs with enriched expression in the SCN, (ii) generate mutant animals deficient in candidate GPCRs, and (iii) analyse the impact on circadian rhythms. We thereby identify Gpr176 as an SCN-enriched orphan GPCR that sets the pace of circadian behaviour. Gpr176 is expressed in a circadian manner by SCN neurons, and molecular characterization reveals that it represses cAMP signalling in an agonist-independent manner. Gpr176 acts independently of, and in parallel to, the Vipr2 GPCR, not through the canonical Gi, but via the unique G-protein subclass Gz