686 research outputs found

    Graph-based Approaches to Protein Structure- and Function Prediction

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    The social construct of climate and climate change

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    Different time scales of climate change and their differential perception in society are discussed. A historical examination of natural climate changes during the past millennium suggests that short-term changes, especially crucial changes, trigger a significant response in and by society. Short-term changes correspond to the "time horizon of everyday life", that is, to a time scale from days and weeks to a few years. The anticipated anthropogenic climate changes, however, are expected to occur on a longer time scale. They require a response by society not on the basis of primary experience but on the basis of scientifically constructed scenarios and ways in which such information is represented in the modern media for example. Socio—economic impact research relies on concepts that are based on the premise of perfectly informed actors for the development of optimal adaptation strategies. In contrast to such a conception, we develop the concept of a "social construct of climate" as decisive for the public perception of scientiïŹc knowledge about climate and for public policy on climate change. The concept is illustrated using a number of examples

    TWINLATIN: Twinning European and Latin-American river basins for research enabling sustainable water resources management. Combined Report D3.1 Hydrological modelling report and D3.2 Evaluation report

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    Water use has almost tripled over the past 50 years and in some regions the water demand already exceeds supply (Vorosmarty et al., 2000). The world is facing a “global water crisis”; in many countries, current levels of water use are unsustainable, with systems vulnerable to collapse from even small changes in water availability. The need for a scientifically-based assessment of the potential impacts on water resources of future changes, as a basis for society to adapt to such changes, is strong for most parts of the world. Although the focus of such assessments has tended to be climate change, socio-economic changes can have as significant an impact on water availability across the four main use sectors i.e. domestic, agricultural, industrial (including energy) and environmental. Withdrawal and consumption of water is expected to continue to grow substantially over the next 20-50 years (Cosgrove & Rijsberman, 2002), and consequent changes in availability may drastically affect society and economies. One of the most needed improvements in Latin American river basin management is a higher level of detail in hydrological modelling and erosion risk assessment, as a basis for identification and analysis of mitigation actions, as well as for analysis of global change scenarios. Flow measurements are too costly to be realised at more than a few locations, which means that modelled data are required for the rest of the basin. Hence, TWINLATIN Work Package 3 “Hydrological modelling and extremes” was formulated to provide methods and tools to be used by other WPs, in particular WP6 on “Pollution pressure and impact analysis” and WP8 on “Change effects and vulnerability assessment”. With an emphasis on high and low flows and their impacts, WP3 was originally called “Hydrological modelling, flooding, erosion, water scarcity and water abstraction”. However, at the TWINLATIN kick-off meeting it was agreed that some of these issues resided more appropriately in WP6 and WP8, and so WP3 was renamed to focus on hydrological modelling and hydrological extremes. The specific objectives of WP3 as set out in the Description of Work are

    124-Color Super-resolution Imaging by Engineering DNA-PAINT Blinking Kinetics

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    Optical super-resolution techniques reach unprecedented spatial resolution down to a few nanometers. However, efficient multiplexing strategies for the simultaneous detection of hundreds of molecular species are still elusive. Here, we introduce an entirely new approach to multiplexed super-resolution microscopy by designing the blinking behavior of targets with engineered binding frequency and duration in DNA-PAINT. We assay this kinetic barcoding approach in silico and in vitro using DNA origami structures, show the applicability for multiplexed RNA and protein detection in cells, and finally experimentally demonstrate 124-plex super-resolution imaging within minutes.We thank Martin Spitaler and the imaging facility of the MPI of Biochemistry for confocal imaging support

    Re-Inventing Public Education:The New Role of Knowledge in Education Policy-Making

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    This article focuses on the changing role of knowledge in education policy making within the knowledge society. Through an examination of key policy texts, the Scottish case of Integrated Children Services provision is used to exemplify this new trend. We discuss the ways in which knowledge is being used in order to re-configure education as part of a range of public services designed to meet individuals' needs. This, we argue, has led to a 'scientization' of education governance where it is only knowledge, closely intertwined with action (expressed as 'measures') that can reveal problems and shape solutions. The article concludes by highlighting the key role of knowledge policy and governance in orienting education policy making through a re-invention of the public role of education

    Evaluation of GEOS-5 Sulfur Dioxide Simulations During the Frostburg, MD 2010 Field Campaign.

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    Sulfur dioxide (SO2) is a major atmospheric pollutant with a strong anthropogenic component mostly produced by the combustion of fossil fuel and other industrial activities. As a precursor of sulfate aerosols that affect climate, air quality, and human health, this gas needs to be monitored on a global scale. Global climate and chemistry models including aerosol processes along with their radiative effects are important tools for climate and air quality research. Validation of these models against in-situ and satellite measurements is essential to ascertain the credibility of these models and to guide model improvements. In this study the Goddard Chemistry, Aerosol, Radiation, and Transport (GOCART) module running on-line inside the Goddard Earth Observing System version 5 (GEOS-5) model is used to simulate aerosol and SO2 concentrations. Data taken in November 2010 over Frostburg, Maryland during an SO2 field campaign involving ground instrumentation and aircraft are used to evaluate GEOS-5 simulated SO2 concentrations. Preliminary data analysis indicated the model overestimated surface SO2 concentration, which motivated the examination of mixing processes in the model and the specification of SO2 anthropogenic emission rates. As a result of this analysis, a revision of anthropogenic emission inventories in GEOS-5 was implemented, and the vertical placement of SO2 sources was updated. Results show that these revisions improve the model agreement with observations locally and in regions outside the area of this field campaign. In particular, we use the ground-based measurements collected by the United States Environmental Protection Agency (US EPA) for the year 2010 to evaluate the revised model simulations over North America

    Aircraft Observations of Dust and Pollutants over NE China: Insight into the Meteorological Mechanisms of Long-Range Transport

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    Substantial concentrations of trace gases and aerosols are lofted and carried from Asia over the Pacific producing an inter-hemispheric impact on atmospheric chemistry and climate. The meteorological mechanism leading to this large-scale transport of dust and pollutants remains a major uncertainty in quantifying the global effects of emissions from the developing world. Models and downwind measurements have identified isentropic advection associated with wave cyclones (warm conveyor belt circulation) as an important mechanism. We present data from a case study conducted over Shenyang in NE China as part of EAST-AIRE in April 2005 in which upstream convection, rather than WCB lofting appears to dominate. Observations from instrumented aircraft flights, back trajectories, and satellite images of clouds (GOES) and aerosols (MODIS) are analyzed. In this heavily industrialized and populated region, the warm-sector PBL air ahead of a cold front was highly polluted. In the free troposphere, between ~1000 and 4000 m altitude, concentrations of trace gases and aerosols were lower, but well above background; we measured ~70 ppb O3, ~300 ppb CO, ~2 ppb SO2, and ~ 8x10-5 m-1 aerosol scattering. These observations show that dry (non-precipitating) convection can be an important mechanism for converting local air pollution problems into regional or global atmospheric chemistry problems. Climatological data indicate that spring (MAM) precipitation over NE China is low, about 90 mm compared to 290 mm over the NE US. Cloud cover, however, is similar with cumulus clouds reported about 7% of the time over NE China and about 9% of the time over the NE US suggesting that lofting in dry convective events may be common over NE Asia. Evaluation of models’ convective schemes and further observations near the source regions are called for.NS

    Modelling the hydrologic response of a mesoscale Andean watershed to changes in land use patterns for environmental planning

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    A multidisciplinary approach is followed for analysis of the effect of changes in land use patterns on the hydrologic response of the Vergara watershed (4340 km<sup>2</sup>) located in central Chile. Probable future land use scenarios were generated using heuristic rules and logistic regression models, in order to identify and represent the main pressure on the watershed, namely forestation of extensive areas used for agriculture with rapid growing exotic species. The hydrologic response of the watershed was computed with a physically based distributed precipitation-runoff model, which was calibrated and validated for the current period. Results show that mean annual discharge increase with agricultural land use and diminish with introduced forest coverage. Thus, forestation of areas with introduced species like <I>Pinus radiata</I> and <I>Eucalyptus globulus</I> might be regulated in order to protect the water resources of the watershed
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