40 research outputs found
Results of the cementless Plasmacup in revision total hip arthroplasty: a retrospective study of 72 cases with an average follow-up of eight years
Walking on common ground: a cross-disciplinary scoping review on the clinical utility of digital mobility outcomes
Physical mobility is essential to health, and patients often rate it as a high-priority clinical outcome. Digital mobility outcomes (DMOs), such as real-world gait speed or step count, show promise as clinical measures in many medical conditions. However, current research is nascent and fragmented by discipline. This scoping review maps existing evidence on the clinical utility of DMOs, identifying commonalities across traditional disciplinary divides. In November 2019, 11 databases were searched for records investigating the validity and responsiveness of 34 DMOs in four diverse medical conditions (Parkinson’s disease, multiple sclerosis, chronic obstructive pulmonary disease, hip fracture). Searches yielded 19,672 unique records. After screening, 855 records representing 775 studies were included and charted in systematic maps. Studies frequently investigated gait speed (70.4% of studies), step length (30.7%), cadence (21.4%), and daily step count (20.7%). They studied differences between healthy and pathological gait (36.4%), associations between DMOs and clinical measures (48.8%) or outcomes (4.3%), and responsiveness to interventions (26.8%). Gait speed, step length, cadence, step time and step count exhibited consistent evidence of validity and responsiveness in multiple conditions, although the evidence was inconsistent or lacking for other DMOs. If DMOs are to be adopted as mainstream tools, further work is needed to establish their predictive validity, responsiveness, and ecological validity. Cross-disciplinary efforts to align methodology and validate DMOs may facilitate their adoption into clinical practice
Walking on common ground: a cross-disciplinary scoping review on the clinical utility of digital mobility outcomes
Physical mobility is essential to health, and patients often rate it as a high-priority clinical outcome. Digital mobility outcomes (DMOs), such as real-world gait speed or step count, show promise as clinical measures in many medical conditions. However, current research is nascent and fragmented by discipline. This scoping review maps existing evidence on the clinical utility of DMOs, identifying commonalities across traditional disciplinary divides. In November 2019, 11 databases were searched for records investigating the validity and responsiveness of 34 DMOs in four diverse medical conditions (Parkinson’s disease, multiple sclerosis, chronic obstructive pulmonary disease, hip fracture). Searches yielded 19,672 unique records. After screening, 855 records representing 775 studies were included and charted in systematic maps. Studies frequently investigated gait speed (70.4% of studies), step length (30.7%), cadence (21.4%), and daily step count (20.7%). They studied differences between healthy and pathological gait (36.4%), associations between DMOs and clinical measures (48.8%) or outcomes (4.3%), and responsiveness to interventions (26.8%). Gait speed, step length, cadence, step time and step count exhibited consistent evidence of validity and responsiveness in multiple conditions, although the evidence was inconsistent or lacking for other DMOs. If DMOs are to be adopted as mainstream tools, further work is needed to establish their predictive validity, responsiveness, and ecological validity. Cross-disciplinary efforts to align methodology and validate DMOs may facilitate their adoption into clinical practice
Experimental examination of the effectiveness of a supporting screw in condylar plate osteosynthesis of the proximal femur
Total Synthesis of Legionaminic Acid as Basis for Serological Studies
Legionaminic
acid is a nine-carbon diamino monosaccharide that
is found coating the surface of various bacterial human pathogens.
Its unique structure makes it a valuable biological probe, but access
via isolation is difficult and no practical synthesis has been reported.
We describe a stereoselective synthesis that yields a legionaminic
acid building block as well as linker-equipped conjugation-ready legionaminic
acid starting from cheap d-threonine. To set the desired
amino and hydroxyl group pattern of the target, we designed a concise
sequence of stereoselective reactions. The key transformations rely
on chelation-controlled organometallic additions and a Petasis multicomponent
reaction. The legionaminic acid was synthesized in a form that enables
attachment to surfaces. Glycan microarray containing legionaminic
acid revealed that human antibodies bind the synthetic glycoside.
The synthetic bacterial monosaccharide is a valuable probe to detect
an immune response to bacterial pathogens such as Legionella
pneumophila, the causative agent of Legionnaire’s
disease
Total Synthesis of Legionaminic Acid as Basis for Serological Studies
Legionaminic
acid is a nine-carbon diamino monosaccharide that
is found coating the surface of various bacterial human pathogens.
Its unique structure makes it a valuable biological probe, but access
via isolation is difficult and no practical synthesis has been reported.
We describe a stereoselective synthesis that yields a legionaminic
acid building block as well as linker-equipped conjugation-ready legionaminic
acid starting from cheap d-threonine. To set the desired
amino and hydroxyl group pattern of the target, we designed a concise
sequence of stereoselective reactions. The key transformations rely
on chelation-controlled organometallic additions and a Petasis multicomponent
reaction. The legionaminic acid was synthesized in a form that enables
attachment to surfaces. Glycan microarray containing legionaminic
acid revealed that human antibodies bind the synthetic glycoside.
The synthetic bacterial monosaccharide is a valuable probe to detect
an immune response to bacterial pathogens such as Legionella
pneumophila, the causative agent of Legionnaire’s
disease