History of water and health from ancient civilizations to modern times

Abstract This paper examines the influence of water on public health throughout history. Farming, settling down and building of villages and towns meant the start of the problems mankind suffers from this very day -how to get drinkable water for humans and cattle and how to manage the waste we produce. The availability of water in large quantities has been considered an essential part of a civilized way of life in different periods: Roman baths needed a lot of water as does the current Western way of life with water closets and showers. The importance of good quality drinking water was realized already in antiquity, yet the importance of proper sanitation was not understood until the 19th century

Heavy flavor diffusion in weakly coupled N=4 Super Yang-Mills theory

We use perturbation theory to compute the diffusion coefficient of a heavy quark or scalar moving in N=4 SU(N_c) Super Yang-Mills plasma to leading order in the coupling and the ratio T/M<<1. The result is compared both to recent strong coupling calculations in the same theory and to the corresponding weak coupling result in QCD. Finally, we present a compact and simple formulation of the Lagrangian of our theory, N=4 SYM coupled to a massive fundamental N=2 hypermultiplet, which is well-suited for weak coupling expansions.Comment: 22 pages, 4 figures; v3: error corrected in calculations, figures and discussion modified accordingl

Host--parasite models on graphs

The behavior of two interacting populations, ``hosts''and ``parasites'', is investigated on Cayley trees and scale-free networks. In the former case analytical and numerical arguments elucidate a phase diagram, whose most interesting feature is the absence of a tri-critical point as a function of the two independent spreading parameters. For scale-free graphs, the parasite population can be described effectively by Susceptible-Infected-Susceptible-type dynamics in a host background. This is shown both by considering the appropriate dynamical equations and by numerical simulations on Barab\'asi-Albert networks with the major implication that in the termodynamic limit the critical parasite spreading parameter vanishes.Comment: 10 pages, 6 figures, submitted to PRE; analytics redone, new calculations added, references added, appendix remove

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Anomalous specific heat in high-density QED and QCD

Long-range quasi-static gauge-boson interactions lead to anomalous (non-Fermi-liquid) behavior of the specific heat in the low-temperature limit of an electron or quark gas with a leading $T\ln T^{-1}$ term. We obtain perturbative results beyond the leading log approximation and find that dynamical screening gives rise to a low-temperature series involving also anomalous fractional powers $T^{(3+2n)/3}$. We determine their coefficients in perturbation theory up to and including order $T^{7/3}$ and compare with exact numerical results obtained in the large-$N_f$ limit of QED and QCD.Comment: REVTEX4, 6 pages, 2 figures; v2: minor improvements, references added; v3: factor of 2 error in the T^(7/3) coefficient corrected and plots update

Nuclear forces from chiral EFT: The unfinished business

In spite of the great progress we have seen in recent years in the derivation of nuclear forces from chiral effective field theory (EFT), some important issues are still unresolved. In this contribution, we discuss the open problems which have particular relevance for microscopic nuclear structure, namely, the proper renormalization of chiral nuclear potentials and sub-leading many-body forces.Comment: 16 pages, 3 figures; contribution to J. Phys. G, Special Issue, Focus Section: Open Problems in Nuclear Structur

Towards flavour diffusion coefficient and electrical conductivity without ultraviolet contamination

By subtracting from a recent lattice measurement of the thermal vector-current correlator the known 5-loop vacuum contribution, we demonstrate that the remainder is small and shows no visible short-distance divergence. It can therefore in principle be subjected to model-independent analytic continuation. Testing a particular implementation, we obtain estimates for the flavour-diffusion coefficient (2 pi T D \gsim 0.8) and electrical conductivity which are significantly smaller than previous results. Although systematic errors remain beyond control at present, some aspects of our approach could be of a wider applicability.Comment: 7 pages. v2: clarifications added, published versio

Prenatal maternal distress associates with a blunted cortisol response in rhinovirus-positive infants

Introduction: Prenatal exposure to maternal psychological distress (PD) may have programming effects on the fetus/infant hypothalamic-pituitary-adrenal (HPA) axis and subsequently on the development of the fetus’ immune function. Therefore, our aim was to study whether prenatal exposure to PD is related to early infant HPA axis reactivity in the context of a subclinical rhinovirus infection that challenges infants HPA axis postnatally.Methods: This study included 336 10-week-old infants from the nested case control Focus Cohort of the FinnBrain Birth Cohort Study. The outcome was infant HPA axis reactivity in a stress test. The acute stressor comprised of pediatric examination with venipuncture and nasal swabs for virus assessment. Saliva cortisol samples were collected at 5 time points: baseline, 0, 15, 25 and 35 min after the stressor. HPA axis reactivity was defined by the cumulative post-stressor cortisol concentration.Results: HPA axis reactivity was blunted in the PD/rhinovirus + group compared to the average of control/rhinovirus+, PD/rhinovirus-, and control/rhinovirus- groups (difference: 14.7 ln [nmol/L] × min, 95% confidence interval 3.8–25.6, p =  .008). HPA axis reactivity was significantly blunted only in boys with rhinovirus detected when separately tested for boys and girls (p =  .04).Conclusion: Our finding of PD-exposed rhinovirus-positive infants having blunted cortisol secretion gives rise to a hypothesis that maternal PD during pregnancy influences infant HPA axis functioning and the functioning of the immune system. Future studies are needed to test whether this suppression of the HPA axis that co-occurs with rhinovirus infection associates with later disease development (e.g., asthma).</p

Nanomolar Protein-Protein Interaction Monitoring with a Label-Free Protein-Probe Technique

Protein-protein interactions (PPIs) are an essential part of correct cellular functionality, making them increasingly interesting drug targets. While Forster resonance energy transfer-based methods have traditionally been widely used for PPI studies, label-free techniques have recently drawn significant attention. These methods are ideal for studying PPIs, most importantly as there is no need for labeling of either interaction partner, reducing potential interferences and overall costs. Already, several different label-free methods are available, such as differential scanning calorimetry and surface plasmon resonance, but these biophysical methods suffer from low to medium throughput, which reduces suitability for high-throughput screening (HTS) of PPI inhibitors. Differential scanning fluorimetry, utilizing external fluorescent probes, is an HTS compatible technique, but high protein concentration is needed for experiments. To improve the current concepts, we have developed a method based on time-resolved luminescence, enabling PPI monitoring even at low nanomolar protein concentrations. This method, called the protein probe technique, is based on a peptide conjugated with Eu3+ chelate, and it has already been applied to monitor protein structural changes and small molecule interactions at elevated temperatures. Here, the applicability of the protein probe technique was demonstrated by monitoring single-protein pairing and multiprotein complexes at room and elevated temperatures. The concept functionality was proven by using both artificial and multiple natural protein pairs, such as KRAS and eIF4A together with their binding partners, and C-reactive protein in a complex with its antibody