373 research outputs found
Negatief in het nieuws:Een experimenteel onderzoek naar de invloed van negatieve publiciteit op het bedrijfsimago
State of the science on controversial topics: orthodontic therapy and gingival recession (a report of the Angle Society of Europe 2013 meeting).
BACKGROUND: Controversy exists in the literature between the role of orthodontic treatment and gingival recession. Whilst movement of teeth outside the alveolar bone has been reported as a risk factor for gingival recession, others have found no such association. FINDINGS: The Angle Society of Europe devoted a study day to explore the evidence surrounding these controversies. The aim of the day was for a panel of experts to evaluate the current evidence base in relation to either the beneficial or detrimental effects of orthodontic treatment on the gingival tissue. CONCLUSIONS: There remains a relatively weak evidence base for the role of orthodontic treatment and gingival recession and thus a need to undertake a risk assessment and appropriate consent prior to the commencement of treatment. In further prospective, well designed trials are needed
Triggers of defensive medical behaviours: a cross-sectional study among physicians in the Netherlands.
Objectives This study investigated whether the attitudes
of physicians towards justified and unjustified litigation,
and their perception of patient pressure in demanding
care, influence their use of defensive medical behaviours.
Design Cross-sectional survey using exploratory factor
analysis was conducted to determine litigation attitude and
perceived patient pressure factors. Regression analyses
were used to regress these factors on to the ordering of
extra tests or procedures (defensive assurance behaviour)
or the avoidance of high-risk patients or procedures
(defensive avoidance behaviour).
Setting Data were collected from eight Dutch hospitals.
Participants Respondents were 160 physicians and 54
residents (response rate 25%) of
Lifespan-Extending Caloric Restriction or mTOR Inhibition Impair Adaptive Immunity of Old Mice By Distinct Mechanisms
Aging of the world population and a concomitant increase in age-related diseases and disabilities mandates the search for strategies to increase healthspan, the length of time an individual lives healthy and productively. Due to the age-related decline of the immune system, infectious diseases remain among the top 5–10 causes of mortality and morbidity in the elderly, and improving immune function during aging remains an important aspect of healthspan extension. Calorie restriction (CR) and more recently rapamycin (rapa) feeding have both been used to extend lifespan in mice. Preciously few studies have actually investigated the impact of each of these interventions upon in vivo immune defense against relevant microbial challenge in old organisms. We tested how rapa and CR each impacted the immune system in adult and old mice. We report that each intervention differentially altered T-cell development in the thymus, peripheral T-cell maintenance, T-cell function and host survival after West Nile virus infection, inducing distinct but deleterious consequences to the aging immune system. We conclude that neither rapa feeding nor CR, in the current form/administration regimen, may be optimal strategies for extending healthy immune function and, with it, lifespan
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