Nonminimal supersymmetric standard model with lepton number violation

We carry out a detailed analysis of the nonminimal supersymmetric standard model with lepton number violation. The model contains a unique trilinear lepton number violating term in the superpotential which can give rise to neutrino masses at the tree level. We search for the gauged discrete symmetries realized by cyclic groups which preserve the structure of the associated trilinear superpotential of this model, and which satisfy the constraints of the anomaly cancellation. The implications of this trilinear lepton number violating term in the superpotential and the associated soft supersymmetry breaking term on the phenomenology of the light neutrino masses and mixing is studied in detail. We evaluate the tree and loop level contributions to the neutrino mass matrix in this model. We search for possible suppression mechanism which could explain large hierarchies and maximal mixing angles.Comment: Latex file, 43 pages, 2 figure

Probing SO(10) symmetry breaking patterns through sfermion mass relations

We consider supersymmetric SO(10) grand unification where the unified gauge group can break to the Standard Model gauge group through different chains. The breaking of SO(10) necessarily involves the reduction of the rank, and consequent generation of non-universal supersymmetry breaking scalar mass terms. We derive squark and slepton mass relations, taking into account these non-universal contributions to the sfermion masses, which can help distinguish between the different chains through which the SO(10) gauge group breaks to the Standard Model gauge group. We then study some implications of these non-universal supersymmetry breaking scalar masses for the low energy phenomenology.Comment: 13 pages, latex using revtex4, contains 2 figures, replaced with version accepted for publicatio

Squark and slepton masses as probes of supersymmetric SO(10) unification

We carry out an analysis of the non-universal supersymmetry breaking scalar masses arising in SO(10) supersymmetric unification. By considering patterns of squark and slepton masses, we derive a set of sum rules for the sfermion masses which are independent of the manner in which SO(10) breaks to the Standard Model gauge group via its SU(5) subgroups. The phenomenology arising from such non-universality is unaffected by the symmetry breaking pattern, so long as the breaking occurs via any of the SU(5) subgroups of the SO(10) group.Comment: 15 pages using RevTe

Defects in coding joint formation in vivo in developing ATM-deficient B and T lymphocytes

Ataxia-telangiectasia mutated (ATM)–deficient lymphocytes exhibit defects in coding joint formation during V(D)J recombination in vitro. Similar defects in vivo should affect both T and B cell development, yet the lymphoid phenotypes of ATM deficiency are more pronounced in the T cell compartment. In this regard, ATM-deficient mice exhibit a preferential T lymphopenia and have an increased incidence of nontransformed and transformed T cells with T cell receptor α/δ locus translocations. We demonstrate that there is an increase in the accumulation of unrepaired coding ends during different steps of antigen receptor gene assembly at both the immunoglobulin and T cell receptor loci in developing ATM-deficient B and T lymphocytes. Furthermore, we show that the frequency of ATM-deficient αβ T cells with translocations involving the T cell receptor α/δ locus is directly related to the number of T cell receptor α rearrangements that these cells can make during development. Collectively, these findings demonstrate that ATM deficiency leads to broad defects in coding joint formation in developing B and T lymphocytes in vivo, and they provide a potential molecular explanation as to why the developmental impact of these defects could be more pronounced in the T cell compartment

The Minimal Solution to the mu/B_mu Problem in Gauge Mediation

We provide a minimal solution to the mu/B_mu problem in the gauge mediated supersymmetry breaking by introducing a Standard Model singlet filed S with a mass around the messenger scale which couples to the Higgs and messenger fields. This singlet is nearly supersymmetric and acquires a relatively small Vacuum Expectation Value (VEV) from its radiatively generated tadpole term. Consequently, both mu and B_mu parameters receive the tree-level and one-loop contributions, which are comparable due to the small S VEV. Because there exists a proper cancellation in such two kinds of contributions to B_mu, we can have a viable Higgs sector for electroweak symmetry breaking.Comment: 15 pages, 2 figures, version published on JHE

Production and Two-photon Decay of the MSSM Scalar Higgs Bosons at the LHC

We consider the production and two-photon decay of the $CP$-even Higgs bosons ($h^0$ and $H^0$) of the Minimal Supersymmetric Standard Model (MSSM) at the Large Hadron Collider. We study in detail the dependence of the cross section on various parameters of the MSSM, especially the dependence on the mixing effects in the squark sector due to the Higgs bilinear parameter $\mu$ and the soft supersymmetry breaking parameter $A$. We find that the cross section for the production of these Higgs bosons has a significant dependence on the parameters which determine the chiral mixing in the squark sector. The cross section times the two-photon branching ratio of $h^0$ is of the order of 15--25~fb in much of the parameter space that remains after imposing the present experimental constraints. For the $H^0$ the two-photon branching ratio is only significant if the $H^0$ is light, but then the cross section times the branching ratio may exceed 200~fb. The QCD corrections due to quark loop contributions are known to increase the cross section by 50\%. We find the dependence of the cross section on the gluon distribution function used to be rather insignificant.Comment: 16 pages, LaTex, plus 9 uuencoded figures attached Full ps file available at ftp://vsfys1.fi.uib.no/anonymous/pub/ as nordita-9548.ps or nordita-9548.ps-gz or via http://vsfys1.fi.uib.no/thpubl/publications.htm

Early rise in brain damage markers and high ICOS expression in CD4+ and CD8+ T cells during checkpoint inhibitor-induced encephalomyelitis

We report a case of rapid eradication of melanoma brain metastases and simultaneous near-fatal encephalomyelitis following double immune checkpoint blockade. Brain damage marker S-100B and C reactive protein increased before symptoms or signs of encephalomyelitis and peaked when the patient fell into a coma. At that point, additional brain damage markers and peripheral T cell phenotype was analyzed. The analyses were repeated four times during the patient’s recovery. Axonal damage marker neurofilament light polypeptide (NFL) and astrocytic damage marker glial fibrillar acidic protein (GFAP) were very high in blood and cerebrospinal fluid and gradually normalized after immunosuppression and intensive care. The costimulatory receptor inducible T cell costimulatory receptor (ICOS) was expressed on a high proportion of CD4+ and CD8+T cells as encephalomyelitis symptoms peaked and then gradually decreased in parallel with clinical improvement. Both single and double immune checkpoint inhibitor-treated melanoma patients with other serious immune-related adverse events (irAE) (n=9) also expressed ICOS on a significantly higher proportion of CD4+ and CD8+T cells compared with controls without irAE (n=12). In conclusion, our results suggest a potential role for ICOS on CD4+ and CD8+T cells in mediating encephalomyelitis and other serious irAE. In addition, brain damage markers in blood could facilitate early diagnosis of encephalitis

Zeroing In On the Top Quark, LSP and Scalar Higgs Masses

We estimate the top quark, lightest sparticle (LSP) and scalar higgs masses within a supersymmetric grand unified framework in which $\tan\beta \simeq m_t/m_b$ and the electroweak symmetry is radiatively broken. The requirement that the calculated $b$ quark mass lie close to its measured value, together with the cosmological constraint $\Omega_{LSP} \approx 1$, fixes the top quark mass to be $m_t(m_t) \approx 170 \pm 15\ GeV$. The LSP (of bino purity $\stackrel{_>}{_\sim} 98\%)$ has mass $\sim 200 - 350\ GeV$. In the scalar higgs sector the CP-odd scalar mass $m_A \stackrel{_<}{_\sim} 220\ GeV$. With $m_A \stackrel{_>}{_\sim} M_Z$, as suggested by the decay $b \rightarrow s\gamma$, we find $M_Z \stackrel{_<}{_\sim} m_{h^0} (m_{H^0}) \stackrel{_<}{_\sim} 140 (220)\ GeV$ and $120\ GeV \stackrel{_<}{_\sim} m_{H^\pm} \stackrel{_<}{_\sim} 240\ GeV$.Comment: 14 pages in plain LaTeX, BA-93-25, PRL-TH-93/

Higgs and SUSY searches at future colliders

In this talk, I discuss some aspects of Higgs searches at future colliders, particularly comparing and contrasting the capabilities of LHC and Next Linear Collider (NLC), including the aspects of Higgs searches in supersymmetric theories. After this, I will discuss how the search and study of sparticles other than the Higgs can give information about the parameters of the Minimal Supersymmetric Standard Model (MSSM).Comment: 20 pages, 12 figures, laTeX, requires pramana.sty,ias.sty added. In the Proceedings of XII DAE symposium, Chandigarh, December 199