Total Body Sodium Depletion and Poor Weight Gain in Children and Young Adults With an Ileostomy

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141860/1/ncp0397.pd

Andreev Reflections in Micrometer-Scale Normal-Insulator-Superconductor Tunnel Junctions

Understanding the subgap behavior of Normal-Insulator-Superconductor (NIS) tunnel junctions is important in order to be able to accurately model the thermal properties of the junctions. Hekking and Nazarov developed a theory in which NIS subgap current in thin-film structures can be modeled by multiple Andreev reflections. In their theory, the current due to Andreev reflections depends on the junction area and the junction resistance area product. We have measured the current due to Andreev reflections in NIS tunnel junctions for various junction sizes and junction resistance area products and found that the multiple reflection theory is in agreement with our data

Point vortices and classical orthogonal polynomials

Stationary equilibria of point vortices with arbitrary choice of circulations in a background flow are studied. Differential equations satisfied by generating polynomials of vortex configurations are derived. It is shown that these equations can be reduced to a single one. It is found that polynomials that are Wronskians of classical orthogonal polynomials solve the latter equation. As a consequence vortex equilibria at a certain choice of background flows can be described with the help of Wronskians of classical orthogonal polynomials.Comment: 20 pages, 12 figure

The invisible power of fairness. How machine learning shapes democracy

Many machine learning systems make extensive use of large amounts of data regarding human behaviors. Several researchers have found various discriminatory practices related to the use of human-related machine learning systems, for example in the field of criminal justice, credit scoring and advertising. Fair machine learning is therefore emerging as a new field of study to mitigate biases that are inadvertently incorporated into algorithms. Data scientists and computer engineers are making various efforts to provide definitions of fairness. In this paper, we provide an overview of the most widespread definitions of fairness in the field of machine learning, arguing that the ideas highlighting each formalization are closely related to different ideas of justice and to different interpretations of democracy embedded in our culture. This work intends to analyze the definitions of fairness that have been proposed to date to interpret the underlying criteria and to relate them to different ideas of democracy.Comment: 12 pages, 1 figure, preprint version, submitted to The 32nd Canadian Conference on Artificial Intelligence that will take place in Kingston, Ontario, May 28 to May 31, 201

Sorafenib Effectiveness in Advanced Hepatocellular Carcinoma

Phase III trials show sorafenib improves survival in advanced hepatocellular carcinoma (HCC). Because of narrow trial eligibility, results may not be generalizable to a broader HCC population. We sought to evaluate the effectiveness of initial sorafenib versus no treatment among Medicare beneficiaries with advanced HCC

Mental Health Outcomes during Colorectal Cancer Survivorship: A Review of the Literature

Objective This article reviews literature on adults’ mental health outcomes during acute and long-term colorectal cancer (CRC) survivorship. Methods We identified articles that included at least one measure of psychological symptoms or mental quality of life or well-being through a search of databases (CINAHL, MEDLINE, PsycINFO, and PsycARTICLES). Articles were published between January 2004 and April 2015. Results A significant proportion of CRC survivors experience clinically meaningful levels of anxiety and depressive symptoms or reduced mental well-being across the trajectory of the illness. Demographic, medical, and psychosocial predictors of mental health outcomes were identified. However, few studies were theory-driven, and gaps remain in our understanding of risk and protective factors with respect to mental health outcomes, especially during long-term CRC survivorship. Conclusions Theory-driven longitudinal research with larger samples is required to identify subgroups of CRC survivors with different trajectories of psychological adjustment. Such research would assess adjustment as a function of internal resources (e.g., personality, coping) and external resources (e.g., finances, social support) to inform future interventions for CRC survivors

A threshold phenomenon for embeddings of H0mH^m_0 into Orlicz spaces

We consider a sequence of positive smooth critical points of the Adams-Moser-Trudinger embedding of $H^m_0$ into Orlicz spaces. We study its concentration-compactness behavior and show that if the sequence is not precompact, then the liminf of the $H^m_0$-norms of the functions is greater than or equal to a positive geometric constant.Comment: 14 Page

Spitzer Observations of Low Luminosity Isolated and Low Surface Brightness Galaxies

We examine the infrared properties of five low surface brightness galaxies (LSBGs) and compare them with related but higher surface brightness galaxies, using Spitzer Space Telescope images and spectra. All the LSBGs are detected in the 3.6 and 4.5um bands, representing the stellar population. All but one are detected at 5.8 and 8.0um, revealing emission from hot dust and aromatic molecules, though many are faint or point-like at these wavelengths. Detections of LSBGs at the far-infrared wavelengths, 24, 70, and 160um, are varied in morphology and brightness, with only two detections at 160um, resulting in highly varied spectral energy distributions. Consistent with previous expectations for these galaxies, we find that detectable dust components exist for only some LSBGs, with the strength of dust emission dependent on the existence of bright star forming regions. However, the far-infrared emission may be relatively weak compared with normal star-forming galaxies.Comment: 20 pages, 8 figures, accepted to Ap

Locoregional and systemic therapy for hepatocellular carcinoma

The management of hepatocellular carcinoma (HCC) remains challenging due to late presentation and the presence of accompanying liver dysfunction. As such, most patients are not eligible for curative resection and liver transplant. Management in this scenario depends on a number of factors including hepatic function, tumor burden, patency of hepatic vasculature and patients' functional status. Based on these, patients can be offered catheter based intra-arterial therapy for intermediate stage disease and in more advanced disease, sorafenib. Given recent data, regorafenib is now an option following failure of sorafenib. Catheter directed intra-arterial therapy takes advantage of tumor hypervascularity and the unique dual blood supply of the liver, as hepatic tumors receive arterial perfusion via the hepatic artery while the rest of the liver is supplied by the portal vein. This allows selective embolization and delivery of chemotherapeutic agents to the tumor. Compared to best supportive care, intra-arterial therapy offers a survival benefit in intermediate stage HCC and is the recommended approach for treatment. None of the catheter based approaches; including bland embolization, conventional trans-arterial chemoembolization (cTACE), drug eluting bead trans-arterial chemoembolization (DEB-TACE) or trans-arterial radioembolization (TARE) offers a clear advantage over the other, although DEB-TACE may be characterized by less systemic toxicity. All of these approaches are contraindicated in patients with portal vein thrombosis (PVT). On the other hand, intra-arterial, radio embolization, with Yttrium-90 (Y90) can be offered to patients with PVT. The place of this modality in management of HCC is still being investigated. The role of sorafenib in advanced HCC is not in doubt, as until recently, it was the only systemic therapy approved for the management in this setting. This is despite multiple trials evaluating other agents. The addition of sorafenib to catheter-based therapy in intermediate stage disease has also failed to show any benefit. The modest survival benefit with sorafenib and the failure of other targeted agents suggest that it is important to look beyond inhibition of angiogenesis in advanced HCC. Identification of key drivers and mediators of HCC remains paramount for successful drug development. In line with this, it is refreshing that the excitement that has followed developments in cancer immunotherapy is finding its way to HCC with early trials of anti-PD1 monoclonal antibodies showing sufficient activity that phase III trials are now ongoing for Pembrolizumab and Nivolumab in advanced HCC. Future drug development efforts will focus on defining the feasibility of combining different treatment approaches targeting multiple important modulators of HCC

Implementation of Multidimensional Databases with Document-Oriented NoSQL

International audienceNoSQL (Not Only SQL) systems are becoming popular due to known advantages such as horizontal scalability and elasticity. In this paper, we study the implementation of data warehouses with document-oriented NoSQL systems. We propose mapping rules that transform the multidimensional data model to logical document-oriented models. We consider three different logical models and we use them to instantiate data warehouses. We focus on data loading, model-to-model conversion and OLAP cuboid computation