38 research outputs found
The Interleukin-6 inflammation pathway from cholesterol to aging – Role of statins, bisphosphonates and plant polyphenols in aging and age-related diseases
Get PDFWe describe the inflammation pathway from Cholesterol to Aging. Interleukin 6 mediated inflammation is implicated in age-related disorders including Atherosclerosis, Peripheral Vascular Disease, Coronary Artery Disease, Osteoporosis, Type 2 Diabetes, Dementia and Alzheimer's disease and some forms of Arthritis and Cancer. Statins and Bisphosphonates inhibit Interleukin 6 mediated inflammation indirectly through regulation of endogenous cholesterol synthesis and isoprenoid depletion. Polyphenolic compounds found in plants, fruits and vegetables inhibit Interleukin 6 mediated inflammation by direct inhibition of the signal transduction pathway. Therapeutic targets for the control of all the above diseases should include inhibition of Interleukin-6 mediated inflammation
A novel and selective motilin receptor antagonist, GM-109, inhibits contractile response to GM-611, an acid-stable erythromycin a derivative, in the rabbit small intestine
No full textSrc family kinases and nitric oxide production are required for hepatocyte growth factor-stimulated endothelial cell growth
No full textRolling characteristics and optimum roll diameter of symmetric cluster mill
No full text30.00; Translated from Japanese (J. Jpn. Soc. Technol. Plast. 1986 v. 27(304) p. 606-612)Available from British Library Document Supply Centre- DSC:9022.06(BISI--25393)T / BLDSC - British Library Document Supply CentreSIGLEGBUnited Kingdo
Estimation of kelp forest, Laminaria spp., distributions in coastal waters of the Shiretoko Peninsula, Hokkaido, Japan, using echosounder and geostatistical analysis
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