503 research outputs found
Precision control of thermal transport in cryogenic single-crystal silicon devices
We report on the diffusive-ballistic thermal conductance of multi-moded
single-crystal silicon beams measured below 1 K. It is shown that the phonon
mean-free-path is a strong function of the surface roughness
characteristics of the beams. This effect is enhanced in diffuse beams with
lengths much larger than , even when the surface is fairly smooth, 5-10
nm rms, and the peak thermal wavelength is 0.6 m. Resonant phonon
scattering has been observed in beams with a pitted surface morphology and
characteristic pit depth of 30 nm. Hence, if the surface roughness is not
adequately controlled, the thermal conductance can vary significantly for
diffuse beams fabricated across a wafer. In contrast, when the beam length is
of order , the conductance is dominated by ballistic transport and is
effectively set by the beam area. We have demonstrated a uniformity of 8%
in fractional deviation for ballistic beams, and this deviation is largely set
by the thermal conductance of diffuse beams that support the
micro-electro-mechanical device and electrical leads. In addition, we have
found no evidence for excess specific heat in single-crystal silicon membranes.
This allows for the precise control of the device heat capacity with normal
metal films. We discuss the results in the context of the design and
fabrication of large-format arrays of far-infrared and millimeter wavelength
cryogenic detectors
Quantum Effects in the Mechanical Properties of Suspended Nanomechanical Systems
We explore the quantum aspects of an elastic bar supported at both ends and
subject to compression. If strain rather than stress is held fixed, the system
remains stable beyond the buckling instability, supporting two potential
minima. The classical equilibrium transverse displacement is analogous to a
Ginsburg-Landau order parameter, with strain playing the role of temperature.
We calculate the quantum fluctuations about the classical value as a function
of strain. Excitation energies and quantum fluctuation amplitudes are compared
for silicon beams and carbon nanotubes.Comment: RevTeX4. 5 pages, 3 eps figures. Submitted to Physical Review Letter
Measurement of the Induced Proton Polarization P_n in the 12C(e,e'\vec{p}) Reaction
The first measurements of the induced proton polarization, P_n, for the 12C
(e,e'\vec{p}) reaction are reported. The experiment was performed at quasifree
kinematics for energy and momentum transfer (\omega,q) \approx (294 MeV, 756
MeV/c) and sampled a recoil momentum range of 0-250 MeV/c. The induced
polarization arises from final-state interactions and for these kinematics is
dominated by the real part of the spin-orbit optical potential. The
distorted-wave impulse approximation provides good agreement with data for the
1p_{3/2} shell. The data for the continuum suggest that both the 1s_{1/2} shell
and underlying l > 1 configurations contribute.Comment: 5 pages LaTeX, 2 postscript figures, accepted by Physical Reveiw
Letter
Quasielastic 12C(e,e'p) Reaction at High Momentum Transfer
We measured the 12C(e,e'p) cross section as a function of missing energy in
parallel kinematics for (q,w) = (970 MeV/c, 330 MeV) and (990 MeV/c, 475 MeV).
At w=475 MeV, at the maximum of the quasielastic peak, there is a large
continuum (E_m > 50 MeV) cross section extending out to the deepest missing
energy measured, amounting to almost 50% of the measured cross section. The
ratio of data to DWIA calculation is 0.4 for both the p- and s-shells. At w=330
MeV, well below the maximum of the quasielastic peak, the continuum cross
section is much smaller and the ratio of data to DWIA calculation is 0.85 for
the p-shell and 1.0 for the s-shell. We infer that one or more mechanisms that
increase with transform some of the single-nucleon-knockout into
multinucleon knockout, decreasing the valence knockout cross section and
increasing the continuum cross section.Comment: 14 pages, 7 figures, Revtex (multicol, prc and aps styles), to appear
in Phys Rev
Glucocorticoids alleviate intestinal ER stress by enhancing protein folding and degradation of misfolded proteins
Endoplasmic reticulum (ER) stress in intestinal secretory cells has been linked with colitis in mice and inflammatory bowel disease (IBD). Endogenous intestinal glucocorticoids are important for homeostasis and glucocorticoid drugs are efficacious in IBD. In Winnie mice with intestinal ER stress caused by misfolding of the Muc2 mucin, the glucocorticoid dexamethasone (DEX) suppressed ER stress and activation of the unfolded protein response (UPR), substantially restoring goblet cell Muc2 production. In mice lacking inflammation, a glucocorticoid receptor antagonist increased ER stress, and DEX suppressed ER stress induced by the N-glycosylation inhibitor, tunicamycin (Tm). In cultured human intestinal secretory cells, in a glucocorticoid receptor-dependent manner, DEX suppressed ER stress and UPR activation induced by blocking N-glycosylation, reducing ER Ca2+ or depleting glucose. DEX up-regulated genes encoding chaperones and elements of ER-associated degradation (ERAD), including EDEM1. Silencing EDEM1 partially inhibited DEX's suppression of misfolding-induced ER stress, showing that DEX enhances ERAD. DEX inhibited Tm-induced MUC2 precursor accumulation, promoted production of mature mucin, and restored ER exit and secretion of Winnie mutant recombinant Muc2 domains, consistent with enhanced protein folding. In IBD, glucocorticoids are likely to ameliorate ER stress by promoting correct folding of secreted proteins and enhancing removal of misfolded proteins from the ER
Fabrication of Silicon Backshorts with Improved Out-of-Band Rejection for Waveguide-Coupled Superconducting Detectors
The Cosmology Large Angular Scale Surveyor (CLASS) is a ground-based instrument that will measure the polarization of the cosmic microqave background to search for gravitational waves form a posited epoch of inflation early in the universe's history. This measurement will require integration of superconducting transition-edge sensors with microwave waveguide inputs with good conrol of systematic errors, such as unwanted coupling to stray signals at frequencies outside of a precisely defined microwave band. To address these needs we will present work on the fabrication of silicon quarter-wave backshorts for the CLASS 40GHz focal plane. The 40GHz backshort consists of three degeneratively doped silicon wafers. Two spacer wafers are micromachined with through wafer vins to provide a 2.0mm long square waveguide. The third wafer acts as the backshort cap. The three wafers are bonded at the wafer level by Au-Au thermal compression bonding then aligned and flip chip bonded to the CLASS detector at the chip level. The micromachining techniques used have been optimized to create high aspect ratio waveguides, silicon pillars, and relief trenches with the goal of providing improved out of band signal rejection. We will discuss the fabrication of integrated CLASS superconducting detectors with silicon quarter wave backshorts and present current measurement results
A Measurement of the Electric Form Factor of the Neutron through at (GeV/c)
We report the first measurement of the neutron electric form factor
via using a solid polarized target. was
determined from the beam-target asymmetry in the scattering of longitudinally
polarized electrons from polarized deuterated ammonia, ND. The
measurement was performed in Hall C at Thomas Jefferson National Accelerator
Facility (TJNAF) in quasi free kinematics with the target polarization
perpendicular to the momentum transfer. The electrons were detected in a
magnetic spectrometer in coincidence with neutrons in a large solid angle
segmented detector. We find at (GeV/c).Comment: Latex2e 5 pages, 3 figure
A Measurement of the Interference Structure Function, R_LT, for the 12C(e,e'p) reaction in the Quasielastic Region
The coincidence cross-section and the interference structure function, R_LT,
were measured for the 12C(e,e'p) 11B reaction at quasielastic kinematics and
central momentum transfer of q=400 MeV/c. The measurement was at an opening
angle of theta_pq=11 degrees, covering a range in missing energy of E_m = 0 to
65 MeV. The R_LT structure function is found to be consistent with zero for E_m
> 50 MeV, confirming an earlier study which indicated that R_L vanishes in this
region. The integrated strengths of the p- and s-shell are compared with a
Distorted Wave Impulse Approximation calculation. The s-shell strength and
shape are compared with a Hartree Fock-Random Phase Approximation calculation.
The DWIA calculation overestimates the cross sections for p- and s-shell proton
knockout as expected, but surprisingly agrees with the extracted R_LT value for
both shells. The HF-RPA calculation describes the data more consistently, which
may be due to the inclusion of 2-body currents in this calculation.Comment: 8 Pages LaTex, 5 postscript figures. Submitted to Phys. Rev.
Measurement of the recoil polarization in the p (\vec e, e' \vec p) pi^0 reaction at the \Delta(1232) resonance
The recoil proton polarization has been measured in the p (\vec e,e'\vec p)
pi^0 reaction in parallel kinematics around W = 1232 MeV, Q^2 = 0.121 (GeV/c)^2
and epsilon = 0.718 using the polarized c.w. electron beam of the Mainz
Microtron. Due to the spin precession in a magnetic spectrometer, all three
proton polarization components P_x/P_e = (-11.4 \pm 1.3 \pm 1.4) %, P_y =
(-43.1 \pm 1.3 \pm 2.2) %, and P_z/P_e = (56.2 \pm 1.5 \pm 2.6) % could be
measured simultaneously. The Coulomb quadrupole to magnetic dipole ratio CMR =
(-6.4\pm 0.7_{stat}\pm 0.8_{syst}) % was determined from P_x in the framework
of the Mainz Unitary Isobar Model. The consistency among the reduced
polarizations and the extraction of the ratio of longitudinal to transverse
response is discussed.Comment: 5 pages LaTeX, 1 table, 2 eps figure
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