2,072 research outputs found
Finite-time Lyapunov exponents of deep neural networks
We compute how small input perturbations affect the output of deep neural
networks, exploring an analogy between deep networks and dynamical systems,
where the growth or decay of local perturbations is characterised by
finite-time Lyapunov exponents. We show that the maximal exponent forms
geometrical structures in input space, akin to coherent structures in dynamical
systems. Ridges of large positive exponents divide input space into different
regions that the network associates with different classes. These ridges
visualise the geometry that deep networks construct in input space, shedding
light on the fundamental mechanisms underlying their learning capabilities.Comment: 6 pages, 4 figure
InAs nanowire transistors with multiple, independent wrap-gate segments
We report a method for making horizontal wrap-gate nanowire transistors with
up to four independently controllable wrap-gated segments. While the step up to
two independent wrap-gates requires a major change in fabrication methodology,
a key advantage to this new approach, and the horizontal orientation more
generally, is that achieving more than two wrap-gate segments then requires no
extra fabrication steps. This is in contrast to the vertical orientation, where
a significant subset of the fabrication steps needs to be repeated for each
additional gate. We show that cross-talk between adjacent wrap-gate segments is
negligible despite separations less than 200 nm. We also demonstrate the
ability to make multiple wrap-gate transistors on a single nanowire using the
exact same process. The excellent scalability potential of horizontal wrap-gate
nanowire transistors makes them highly favourable for the development of
advanced nanowire devices and possible integration with vertical wrap-gate
nanowire transistors in 3D nanowire network architectures.Comment: 18 pages, 5 figures, In press for Nano Letters (DOI below
Search for the second forbidden beta decay of 8B to the ground state of 8Be
A significant decay branch of 8B to the ground state of 8Be would extend the
solar neutrino spectrum to higher energies than anticipated in the standard
solar models. These high-energy neutrinos would affect current neutrino
oscillation results and also would be a background to measurements of the hep
process. We have measured the delayed alpha particles from the decay of 8B,
with the goal of observing the two 46-keV alpha particles arising from the
ground-state decay. The 8B was produced using an in-flight radioactive beam
technique. It was implanted in a silicon PIN-diode detector that was capable of
identifying the alpha-particles from the 8Be ground state. From this
measurement we find an upper limit (at 90% confidence level) of 7.3 x 10^{-5}
for the branching ratio to the ground state. In addition to describing this
measurement, we present a theoretical calculation for this branching ratio.Comment: One reference corrected. Minor edits in tex
CARMA Large Area Star Formation Survey: Observational Analysis of Filaments in the Serpens South Molecular Cloud
We present the N2H+(J=1-0) map of the Serpens South molecular cloud obtained
as part of the CARMA Large Area Star Formation Survey (CLASSy). The
observations cover 250 square arcminutes and fully sample structures from 3000
AU to 3 pc with a velocity resolution of 0.16 km/s, and they can be used to
constrain the origin and evolution of molecular cloud filaments. The spatial
distribution of the N2H+ emission is characterized by long filaments that
resemble those observed in the dust continuum emission by Herschel. However,
the gas filaments are typically narrower such that, in some cases, two or three
quasi-parallel N2H+ filaments comprise a single observed dust continuum
filament. The difference between the dust and gas filament widths casts doubt
on Herschel ability to resolve the Serpens South filaments. Some molecular
filaments show velocity gradients along their major axis, and two are
characterized by a steep velocity gradient in the direction perpendicular to
the filament axis. The observed velocity gradient along one of these filaments
was previously postulated as evidence for mass infall toward the central
cluster, but these kind of gradients can be interpreted as projection of
large-scale turbulence.Comment: 12 pages, 4 figures, published in ApJL (July 2014
Quantum transport through a DNA wire in a dissipative environment
Electronic transport through DNA wires in the presence of a strong
dissipative environment is investigated. We show that new bath-induced
electronic states are formed within the bandgap. These states show up in the
linear conductance spectrum as a temperature dependent background and lead to a
crossover from tunneling to thermal activated behavior with increasing
temperature. Depending on the strength of the electron-bath coupling, the
conductance at the Fermi level can show a weak exponential or even an algebraic
length dependence. Our results suggest a new environmental-induced transport
mechanism. This might be relevant for the understanding of molecular conduction
experiments in liquid solution, like those recently performed on poly(GC)
oligomers in a water buffer (B. Xu et al., Nano Lett 4, 1105 (2004)).Comment: 5 pages, 3 figure
CARMA Large Area Star Formation Survey: Project Overview with Analysis of Dense Gas Structure and Kinematics in Barnard 1
We present details of the CARMA Large Area Star Formation Survey (CLASSy),
while focusing on observations of Barnard 1. CLASSy is a CARMA Key Project that
spectrally imaged N2H+, HCO+, and HCN (J=1-0 transitions) across over 800
square arcminutes of the Perseus and Serpens Molecular Clouds. The observations
have angular resolution near 7" and spectral resolution near 0.16 km/s. We
imaged ~150 square arcminutes of Barnard 1, focusing on the main core, and the
B1 Ridge and clumps to its southwest. N2H+ shows the strongest emission, with
morphology similar to cool dust in the region, while HCO+ and HCN trace several
molecular outflows from a collection of protostars in the main core. We
identify a range of kinematic complexity, with N2H+ velocity dispersions
ranging from ~0.05-0.50 km/s across the field. Simultaneous continuum mapping
at 3 mm reveals six compact object detections, three of which are new
detections. A new non-binary dendrogram algorithm is used to analyze dense gas
structures in the N2H+ position-position-velocity (PPV) cube. The projected
sizes of dendrogram-identified structures range from about 0.01-0.34 pc.
Size-linewidth relations using those structures show that non-thermal
line-of-sight velocity dispersion varies weakly with projected size, while rms
variation in the centroid velocity rises steeply with projected size. Comparing
these relations, we propose that all dense gas structures in Barnard 1 have
comparable depths into the sky, around 0.1-0.2 pc; this suggests that
over-dense, parsec-scale regions within molecular clouds are better described
as flattened structures rather than spherical collections of gas. Science-ready
PPV cubes for Barnard 1 molecular emission are available for download.Comment: Accepted to The Astrophysical Journal (ApJ), 51 pages, 27 figures
(some with reduced resolution in this preprint); Project website is at
http://carma.astro.umd.edu/class
Suicides among Danish cancer patients 1971–1999
Compared to the general population, the suicide risk among Danish cancer patients diagnosed in 1971–1986 was increased by 50% for men and 30% for women. We updated the earlier study to evaluate both long-term and recent trends in the suicide risk. Cancer patients with a first cancer diagnosed between 1971 and 1999 in Denmark were followed-up for completed suicide through 1999. Excluding nonmelanoma skin cancer, 564 508 cancer patients were included and 1241 suicides observed. Both the standardised mortality ratio (SMR) of suicide relative to the general population and the suicide rates were analysed with Poisson regression methods. The overall SMR was increased to 1.7 (95% CI. 1.6–1.9) for men and 1.4 (95% CI: 1.3–1.5) for women. Following the cancer diagnosis, the suicide risk was highest in the first 3 months for men and between months 3 and 12 for women. The risk was higher for nonlocalised cancer and for cancers with perceived poor prognosis. Breast cancer patients had a higher risk than other cancer patients with similar good prognosis. The suicide rates among cancer patients decreased with calendar time, but less so than the rates in the general population. The suicide risk among cancer patients has not decreased as much as in the Danish population and reasons for this should be explored. Breast cancer might be believed by patients to be more life threatening than it is. Assessment and treatment of depression could improve the quality of life for cancer patients who suffer from unrecognised depressions and in turn reduce the risk of suicide in cancer patients
Biodegradable Poly(2-Dimethylamino Ethylamino)Phosphazene for In Vivo Gene Delivery to Tumor Cells. Effect of Polymer Molecular Weight
Purpose. Previously, we have shown that complexes of plasmid DNA with the biodegradable polymer poly(2-dimethylamino ethylamino)phosphazene (p(DMAEA)-ppz) mediated tumor selective gene expression after intravenous administration in mice. In this study, we investigated the effect of p(DMAEA)-ppz molecular weight on both in vitro and in vivo tumor transfection, as well as on complex induced toxicity. Materials and Methods. p(DMAEA)-ppz with a broad molar mass distribution was fractionated by preparative size exclusion chromatography. Polyplexes consisting of plasmid DNA and the collected polymer fractions were tested for biophysical properties, (cyto)toxicity and transfection activity. Results. Four p(DMAEA)-ppz fractions were collected with weight average molecular weights ranging from 130 to 950 kDa, and with narrow molecular mass distributions (Mw/Mn from 1.1 to 1.3). At polymer-to-DNA (N/P) ratios above 6, polyplexes based on these polymers were all positively charged (zeta potential 25–29 mV), and had a size of 80–90 nm. The in vitro cytotoxicity of the polyplexes positively correlated with polymer molecular weight. The in vitro transfection activity of the different polyplexes depended on their N/P ratio, and was affected by the degree of cytotoxicity, as well as the colloidal stability of the different polyplexes. Intravenous administration of polyplexes based on the high molecular weight polymers led to apparent toxicity, as a result of polyplex-induced erythrocyte aggregation. On the other hand, administration of polyplexes based on low molecular weight p(DMAEA)-ppz_s (Mw130 kDa) did not show signs of toxicity and resulted in tumor selective gene expression. Conclusion. Polymer molecular weight fractionation enabled us to optimize the transfection efficiency/ toxicity ratio of p(DMAEA)-ppz polyplexes for in vitro and in vivo tumor transfection. KEY WORDS: biodegradable; cationic polymer; DNA; molecular weight; tumor gene delivery
Pollen-Mediated Gene Flow from Genetically Modified Herbicide Resistant Creeping Bentgrass
Approximately 162 ha of multiple experimental fields of creeping bentgrass (Agrostis stolonifera L.) genetically modified for resistance to Roundup ®herbicide, were planted in central Oregon in 2002. When the fields flowered for the first time in the summer of 2003, a unique opportunity was presented to evaluate methods to monitor potential pollen-mediated gene flow from the experimental GM crop fields to compatible sentinel and resident plants that were located in surrounding, primarily non-agronomic areas
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