Evaluation of effect of alcoholic extract of Tinospora cordifolia on learning and memory in alprazolam induced amnesia in albino mice

Background: Tinospora cordifolia is one of the most versatile shrub with cognitive enhancing effects could be beneficial for treatment of dementia and neurodegenerative diseases like alzheimer’s disease. The purpose of study was to evaluate the effect of Tinospora cordifolia on learning and memory in alprazolam induced amnesia in albino mice.Methods: The study was carried out on albino mice, divided into 4 groups of 6 animals each (either sex, 3-4 months of age, weight 25-30g). Amnesia was induced by administering alprazolam (2 mg/kg body weight for 14 days) in all 4 groups for 14 days from 1st to 14th day. Group 1 was given alprazolam (2 mg/kg/p.o) alone for 14 days. In addition, group 2 was given piracetam (400 mg/kg p.o) from 8th to 15th day. Group 3 was given alcoholic extract of Tinospora cordifolia 140 mg/kg, p.o. from 1st to 15th day. Group 4 was given alcoholic extract of Tinospora cordifolia 280 mg/kg, p.o. from 1st to 15th day. The learning and memory of the animals was assessed by employing elevated plus maze (EPM) and step-down type passive avoidance model (SDA).Results: Results were compared among the different groups using one way-ANOVA followed by post hoc Tukey’s test. The measured parameters were compared with standard drug piracetam. Tinospora cordifolia at 140 mg/kg (p<0.02) and 280 mg/kg was significant in both models (p<0.02) and in EPM model, Tinospora cordifolia at 280 mg/kg showed highly significant result (P<0.01).Conclusions: Tinospora cordifolia, Indian medicinal plant useful for treatment of various ailments can also be a useful alternative for treating dementia and associated diseases like alzheimer’s disease

Bank Form Classification using Document Layout Analysis and Image Processing Techniques

Every day thousands of forms are filled out and submitted across the world, in banks, post offices, government organizations, educational institutions etc. These include electronic forms as well as physical forms. All of these forms irrespective of their origin are at some stage made digital and stored electronically to address issues of physical storage, form degradation and data accessibility. Document layout analysis is a basic step in converting document images into electronic form. This conversion is laborious and can be made more efficient (in terms of throughput and human resource) by automating most of the conversion process using document layout analysis techniques. Document classification is an important step in Office Automation, Digital Libraries, and other document image analysis applications. Physical forms require human supervision for any operations done on the form. Digitization of these forms reduces human resources, also reduces any human redundancy involved with the operation on the physical forms. This paper addresses the initial stage of this automation, namely, bank form classification and decipherment of fields. The former recognizes the type of the bank form and the latter extracts regions of useful data from the classified bank form. The proposed work aims to provide accurate bank form classification along with noise removal, skew detection and correction, finally layout analysis is carried out to extract fields like name, address, signature from the classified forms

A study of uterine balloon tamponade for the management postpartum haemorrhage using Bakri balloon

Background: PPH is the most common cause of maternal morbidity and mortality around the world. Incidence of PPH is 2-4% following vaginal delivery and 6% following cesarean delivery in India. Uterine atony is the most common cause of PPH. Treatment of PPH involves medical treatment and surgical management. In between medical and surgical management of PPH comes uterine balloon tamponade which is simple, less invasive and can be managed with minimal training.Methods: A retrospective cohort study was done for 2 years at Vanivilas hospital, Bangalore medical college and research centre, Bangalore, Karnataka. Cases of atonic PPH managed using Bakri balloon were included in the study. The objective of the study was to study the effectiveness of uterine balloon tamponade using Bakri balloon in the management of atonic PPH and to study the maternal outcome.Results: In this study total of 50 cases were included. Women were in the age group of 18 to 33years. Regarding obstetric history, 22 (44%) were primigravida and 28 (56%) was multigravida. Among these 50 cases 8 (16%) women had undergone caesarean delivery and 42(84%) had vaginal delivery. All women received blood transfusion, 17 (34%) received blood and blood components (like PRBC, FFP AND platelets) and 33 (66%) cases received only PRBC transfusion. In these 50 cases, 32 (64%) required ICU admission for monitoring, remaining 18 (36%) were monitored in the labor-room. Bakri balloon was effective in 49 cases among 50. Success rate was 98%.Conclusions: Intrauterine balloon tamponade using Bakri balloon is effective for control of atonic PPH in majority of cases.

Efficacy and safety of 1% terbinafine hydrochloride versus 2% sertaconazole cream in the treatment of tinea corporis

Background: Tinea corporis is a common superficial dermatophytosis seen in tropical countries. This study was done to compare the efficacy and safety of topical antifungal agents, terbinafine versus sertaconazole in the treatment of tinea corporis.Methods: This study was conducted in Babuji Hospital and Chigateri Government Hospital, Davangere. A total of 60 (n=60) patients were included and divided into two groups of 30 patients each in the study. 1st group - received topical 1% terbinafine hydrochloride and 2nd group - received 2% sertaconazole cream. Patients were advised to apply cream twice daily for 4 weeks. Improvement in clinical parameters like erythema, scaling, itching, and potassium hydroxide (KOH) mount were taken for assessing the efficacy of drugs. They were followed-up at the end of 2, 4, and 6 weeks to assess the improvement of the condition. Complete cure rate was defined as mycological cure with a complete absence of clinical signs and symptoms. For safety data of both drugs presence of any local side effects (like stinging sensation, swelling and increased erythema) were analyzed in both groups. Statistical analysis was done using students paired t-test and unpaired t-test.Results: When two groups were compared at the end of 2 weeks, complete cure rate for terbinafine was 80% as compared to 63.3% for sertaconazole (p0.05) results were obtained. KOH mount was negative in both groups at the end of 2nd week. Local side effects like erythema, swelling, stinging sensation were not noticed during the study in both the groups.Conclusion: From this study, it was shown that 2% sertaconazole cream was as effective as 1% terbinafine cream, though 1% terbinafine had higher rates of complete cure at the end of 2 weeks as compared to sertaconazole

Automated Modular Data Analysis and Visualization System with Predictive Analytics Using Machine Learning for Agriculture field

Economy of an India is majorly depending on growth of agricultural yields, and its allied agro industry products. Prediction of agricultural yield growth is a most difficult for the agriculture departments across iglobe. 1The agricultural yields growth is depending on several factors. In this paper historical data is analyzed and a predictive model was designed. 1Several Regression models such as linear model, multiple linear model and nonlinear models were tested for an effective prediction, or for forecasting the agricultural yield for a variety of crops. Along with this the crop trade for local farmers is a very complicated and tedious task and can get easily mislead by the system we are proposing helps them to analyze the crop availability and also according to market prices can be able to predict various characteristics of the trade. The proposed method is capable of producing the visual representation after data analysis and provides the prediction results in a visual format. And also the unstructured data analysis is implemented in the system. In the proposed method, the pre-processed input data will be sent to perform a descriptive analysis and a predictive analysis. In the descriptive analysis, the data is analyzed and the summary of the analysis is given as the output.In Predictive analysis, there are steps to be considered for the analysis. At the end summary of predicted results are given as output and summary of both descriptive analysis and predictive analysis is given as final report in visual format

Energy Efficiency Based Load Balancing Optimization Routing Protocol In 5G Wireless Communication Networks

A significant study area in cloud computing that still requires attention is how to distribute the workload among virtual machines and resources. Main goal of this research is to develop an efficient cloud load balancing approach, improve response time, decrease readiness time, maximise source utilisation, and decrease activity rejection time. This research propose novel technique in load balancing based network optimization using routing protocol for 5G wireless communication networks. the network load balancing has been carried out using cloud based software defined multi-objective optimization routing protocol. then the network security has been enhanced by data classification utilizing deep belief Boltzmann NN. Experimental analysis has been carried out based on load balancing and security data classification in terms of throughput, packet delivery ratio, energy efficiency, latency, accuracy, precision, recall

Comparison of spinal manipulation and short-wave diathermy on patients with chronic postural low back pain, in department of physical medicine at teaching hospital, Kandy, Sri Lanka

Background: Chronic postural low back pain (CPLBP) is one of the common health problems worldwide. The aim of the study was to compare the spinal manipulation (SM) and short-wave diathermy (SWD) in patients with CPLBP in department of physical medicine at teaching hospital, Kandy, Sri Lanka.Methods: Observational study was conducted. Patients diagnosed as CPLBP, who referred to the department of physical medicine (DPM), teaching hospital Kandy, were observed in the study (n=140). Seventy (70) patients were allocated for SWD and 70 for SM by the consultant. Two physiotherapists were routinely appointed for the treatments and SWD treatment by group 1 and SM was carried out by group 2. The two treatment sessions were continued once a week through four weeks. Outcomes were measured by numerical pain scale to compare with initial pain.Results: Group 1, SM consisted 39 females and 31 males, group 2, SWD 40 females and 30 males. After 4 sessions, the mean value of pain reduction from initial pain was significantly high (p&lt;0.001) in SM group than the short-wave diathermy group in both genders. (Female: 6.410 (SM) and 4.625 (SWD), Male:6.710 (SM) and 4.333 (SWD). Further the mean values showed that there was a significant pain reduction during the initial treatment session than 2nd, 3rdand final sessions in both treatment groups.Conclusions: Pain reduction was more pronounced in the first treatment session in both methods. SM is more effective for the treatment of CPLBP irrespectively the age and gender when compare to the SWD in the study population. Therefore, SM could apply on CPLBP patients with higher effective treatment

Draft Genome Sequences from a Novel Clade of <i>Bacillus cereus Sensu Lato </i>Strains, Isolated from the International Space Station

The draft genome sequences of six Bacillus strains, isolated from the International Space Station and belonging to the Bacillus anthracis-B. cereus-B. thuringiensis group, are presented here. These strains were isolated from the Japanese Experiment Module (one strain), U.S. Harmony Node 2 (three strains), and Russian Segment Zvezda Module (two strains)

Taking stock of 10 years of published research on the ASHA programme: Examining India’s national community health worker programme from a health systems perspective

Background: As India’s accredited social health activist (ASHA) community health worker (CHW) programme enters its second decade, we take stock of the research undertaken and whether it examines the health systems interfaces required to sustain the programme at scale. Methods: We systematically searched three databases for articles on ASHAs published between 2005 and 2016. Articles that met the inclusion criteria underwent analysis using an inductive CHW–health systems interface framework. Results: A total of 122 academic articles were identified (56 quantitative, 29 mixed methods, 28 qualitative, and 9 commentary or synthesis); 44 articles reported on special interventions and 78 on the routine ASHA program. Findings on special interventions were overwhelmingly positive, with few negative or mixed results. In contrast, 55% of articles on the routine ASHA programme showed mixed findings and 23% negative, with few indicating overall positive findings, reflecting broader system constraints. Over half the articles had a health system perspective, including almost all those on general ASHA work, but only a third of those with a health condition focus. The most extensively researched health systems topics were ASHA performance, training and capacity-building, with very little research done on programme financing and reporting, ASHA grievance redressal or peer communication. Research tended to be descriptive, with fewer influence, explanatory or exploratory articles, and no predictive or emancipatory studies. Indian institutions and authors led and partnered on most of the research, wrote all the critical commentaries, and published more studies with negative results. Conclusion: Published work on ASHAs highlights a range of small-scale innovations, but also showcases the challenges faced by a programme at massive scale, situated in the broader health system. As the programme continues to evolve, critical comparative research that constructively feeds back into programme reforms is needed, particularly related to governance, intersectoral linkages, ASHA solidarity, and community capacity to provide support and oversight