An inclusion result for dagger closure in certain section rings of abelian varieties

We prove an inclusion result for graded dagger closure for primary ideals in symmetric section rings of abelian varieties over an algebraically closed field of arbitrary characteristic.Comment: 11 pages, v2: updated one reference, fixed 2 typos; final versio

Heterogeneity in a large pedigree with Danon disease: Implications for pathogenesis and management

Background Danon disease is an X-linked disturbance of autophagy manifesting with cognitive impairment and disordered heart and skeletal muscle. After a period of relative stability, patients deteriorate rapidly and may quickly become ineligible for elective heart transplantation - the only life-saving therapy. Methods We report a large pedigree with diverse manifestations of Danon disease in hemizygotes and female heterozygotes. Results Malignant cardiac arrhythmias requiring amiodarone treatment induced thyroid disease in two patients; intractable thyrotoxicosis, which enhances autophagy, caused the death of a 21 year-old man. Our patients also had striking elevation of serum troponin I during the accelerated phase of their illness (pb0.01) and rising concentrations heralded cardiac decompensation. We argue for changes to cardiac transplantation eligibility criteria. Conclusion Danon disease causes hypertrophic cardiomyopathy - here we propose a common pathophysiological basis for the metabolic and structural effects of this descriptive class of heart disorders. We also contend that troponin I may have prognostic value and merits exploration for clinical decision-making including health warning bracelets. Rapamycin (Sirolimus®), an approved immunosuppressant which also influences autophagy, may prove beneficial. In the interim, while new treatments are developed, a revaluation of cardiac transplantation eligibility criteria is warranted.</p

Preliminary study on the smartphone zombie phenomenon by utilising a monitoring application

Abstract Several studies exist on the dangers of using a smartphone while walking. Unfortunately, pedestrians often disregard the warnings either intentionally or by accident as their focus is on the phone and not fully on the surrounding environment or situation. In this paper, we present our preliminary work to study the correlation between smartphone zombie behaviour and individual’s psychological features, to reduce walking use. At first, in order to collect smartphone zombie behaviour from actual users, we have developed a monitoring application for smartphones. We asked seven subjects to install this application and continue living their lives normally for 15 days. For collecting the psychological features, we asked them to answer a profiling questionnaire

Design of assistive tabletop projector-camera system for the elderly with cognitive and motor skill impairments

Abstract Projector-camera (ProCam) systems have a potential to become popular and affordable as they can create interactive surfaces for example on tabletops, walls, household items or on a palm of a hand. The possibility that these systems will be used at homes in the future is increasing. The elderly living alone at home often need assistance in their daily tasks as the likelihood of cognitive and motor skill related impairments increases with age. ProCam systems could be used for guidance due to easy to manipulate large interaction surfaces, but research on its suitability for elderly users is scarce. Our research focus is on elderly users and examining their characteristics as potential users of ProCam systems and the implications for interaction design. We conducted a user study with a mixed impairments group of elderly aged 82–94 to investigate how a personalized and skill-suited user interface should be designed. In our qualitative approach, we discovered that the combinations of both cognitive and motor skill deficiencies of the elderly prohibit one-for-all designs so the user interface design should be adapted to each individual’s interaction skills. Lastly, we make suggestions for designing ProCam interaction for elderly

Outrageous prices of orphan drugs: a call for collaboration

https://www.ncbi.nlm.nih.gov/pubmed/3003773