9,288 research outputs found
Social prescribing : the whys, wherefores and implications for nurses & prescribers.
This article discusses ‘social prescribing’ as a non-medical approach for nurse prescribers that can promote health and wellbeing within a personalised care context as part of the NHS Long Term Plan (DHS 2019). The concept of social prescribing and its origins will be described alongside common interventions and services. This article concludes with an exploration of how social prescribing can be used to compliment nurse prescribing to support personalised care
Shaping the future for primary care education and training project. Best practise in education and training strategies for integrated health and social care: development of a benchmarking tool
Collaboration and partnership working between Higher Education and the NHS is an essential requirement for
effective delivery of care (Universities UK 2003). The North West Universities Association (NWUA) and the North
West Development Agency (NWDA) are two organisations at the forefront of creating such alliances. The
research project, Shaping the Future for Primary Care Education and Training Project is a collaborative
partnership between both these organisations and seven North West Higher Education Institutions. In addition,
the project brings together for the first time all the key partners in the health, social care and education sectors
who are involved in supporting the delivery of integrated health and social care in the North West Region
Prebiotics: a potential treatment strategy for the chemotherapy-damaged gut?
Abstract Mucositis, characterized by ulcerative lesions along the alimentary tract, is a common consequence of many chemotherapy regimens. Chemotherapy negatively disrupts the intestinal microbiota, resulting in increased numbers of potentially pathogenic bacteria, such as Clostridia and Enterobacteriaceae, and decreased numbers of "beneficial" bacteria, such as Lactobacilli and Bifidobacteria. Agents capable of restoring homeostasis in the bowel microbiota could therefore be applicable to mucositis. Prebiotics are indigestible compounds, commonly oligosaccharides, which seek to reverse chemotherapy-induced intestinal dysbiosis through selective colonization of the intestinal microbiota by probiotic bacteria. In addition, evidence is emerging that certain prebiotics contribute to nutrient digestibility and absorption, modulate intestinal barrier function through effects on mucin expression, and also modify mucosal immune responses, possibly via inflammasome-mediated processes. This review examines the known mechanisms of prebiotic action and explores their potential to reduce the severity of chemotherapy-induced mucositis in the intestine.Hanru Wang, Mark S Geier and Gordon S Howart
Recommended from our members
Development of an Integrated Governance Strategy for the Voluntary and Community Sector
This report on governance provides a framework for thinking about how policy makers, funders,regulators and advisers can all work with Board members and staff to enhance the effectiveness of nonprofit organisations. It was commissioned by the Active Community Unit (ACU) of the Home Office, in parallel with other reviews designed to improve the capacity of the voluntary and community sector, at a time when the sector plays an increasingly important role in the delivery of services using public funds. That role has recently been investigated in two Government reports, the Cross Cutting Review carried out by the Treasury, and the Strategy Unit review of charities and nonprofits. Our report proposes actions of three types: some that can be taken immediately, some that require further discussion with key interests, and some integration with the other ACU reviews. Taken together they provide the starting point for an evolving strategy to improve governance across the sector. We recommend ACU chairs a group charged with the responsibility for planning and implementing this. Our focus is on governance as 'the systems and processes concerned with ensuring the overall direction, supervision and accountability of an organisation'. This is often taken to mean the way that a Board, management committee or other governing body steers the overall development of an organisation, where day-to-day management is in the hands of staff or volunteers. Sometimes, of course, the committee and volunteers are the same. They – like all governing bodies – have to balance the interests of the organisation and those they are trying to serve, while being conscious of financial and legal responsibilities, and the requirements of funders and other supporters
FUSE Observations of a Full Orbit of Hercules X-1: Signatures of Disk, Star, and Wind
We observed an entire 1.7 day orbit of the X-ray binary Hercules X-1 with the
Far Ultraviolet Spectroscopic Explorer (FUSE). Changes in the O VI 1032,1037
line profiles through eclipse ingress and egress indicate a Keplerian accretion
disk spinning prograde with the orbit. These observations may show the first
double-peaked accretion disk line profile to be seen in the Hercules X-1
system. Doppler tomograms of the emission lines show a bright spot offset from
the Roche lobe of the companion star HZ Her, but no obvious signs of the
accretion disk. Simulations show that the bright spot is too far offset from
the Roche lobe to result from uneven X-ray heating of its surface. The absence
of disk signatures in the tomogram can be reproduced in simulations which
include absorption from a stellar wind. We attempt to diagnose the state of the
emitting gas from the C III 977, C III 1175, and N III 991 emission lines. The
latter may be enhanced through Bowen fluorescence.Comment: Accepted for publication in The Astrophysical Journa
Umbilical artery Doppler velocimetry in the prediction of intrapartum fetal compromise
CITATION: Howarth, G. R. et al. 1992. Umbilical artery Doppler velocimetry in the prediction of intrapartum fetal compromise. South African Medical Journal, 81:248-250.The original publication is available at http://www.samj.org.zaThe value of early intrapartum umbilical artery Doppler velocimetry in the prediction of fetal compromise was studied. One hundred patients were recruited into the study and fetal compromise was diagnosed by abnormal first- or second-stage fetal heart rate traces, a 5-minute Apgar score less than 7, or the development of hypoxic ischaemic encephalopathy. Fetal compromise developed in 30 patients. An umbilical artery resistance index (RI) of 0,66 or less did not predict fetal compromise (sensitivity 13%, specificity 89%, positive predictive value 25%, negative predictive value 70%). Since the mean umbilical artery RI was identical in the compromised and the noncompromised groups, we conclude that early intrapartum Doppler velocimetry is of very little clinical value in predicting fetal compromise at term.Publisher’s versio
Studies in the Lake Ontario Basin using ERTS-1 and high altitude data
Studies in the Lake Ontario Basin are designed to provide input for models of river basin discharge and macro-scale features of lake circulation. Lake studies appear to require high altitude imagery to record the dynamic features of Lake Ontario so that ERTS-1 data may be interpreted. Land area studies require input of soil moisture, land use and soil-sediment-geomorphology measurements some of which appear to be available, on a regional scale from ERTS-1 products
A Period and a Prediction for the Of?p Spectrum Alternator HD 191612
The observational picture of the enigmatic O-type spectrum variable HD191612
has been sharpened substantially. A symmetrical, low-amplitude light curve with
a period near 540 d has recently been reported from Hipparcos photometry. This
period satisfies all of the spectroscopy since at least 1982, including
extensive new observations during 2003 and 2004, and it has predicted the next
transition during September--October 2004. Measurements of the H alpha
equivalent width reveal a sharp emission peak in the phase diagram, in contrast
to the apparently sinusoidal light curve. The He II absorption-line strength is
essentially constant, while He I varies strongly, possibly filled in by
emission in the O6 state, thus producing the apparent spectral-type variations.
The O8 state appears to be the "normal" one. Two intermediate O7 observations
have been obtained, which fall at the expected phases, but these are the only
modern observations of the transitions so far. The period is too long for
rotation or pulsation; although there is no direct evidence as yet for a
companion, a model in which tidally induced oscillations drive an enhanced wind
near periastron of an eccentric orbit appears promising. Further observations
during the now predictable transitions may provide a critical test. Ultraviolet
and X-ray observations during both states will likely also prove illuminating.Comment: 7 pages, 3 figures, 1 table; scheduled for the 2004 December 10 issue
of ApJL, Vol. 617, No. 1. ApJ
New publication: the social psychology of everyday politics
Newly published book The Social Psychology of Everyday Politics edited by Associate Professor Caroline Howarth and Dr Eleni Andreouli features chapters by PhD candidate Geetha Reddy and Dr Ilka Gleibs, and PhD candidate Sandra Obradovic and Associate Professor Caroline Howarth
Polarization due to rotational distortion in the bright star Regulus
This is the full published article (retrieved from the 6 months post-publication posting on arXiv) including the Methods and Supplementary Information sections: 33 pages, 10 figures, 8 tablesPolarization in stars was first predicted by Chandrasekhar [1] who calculated a substantial linear polarization at the stellar limb for a pure electron-scattering atmosphere. This polarization will average to zero when integrated over a spherical star but could be detected if the symmetry is broken, for example by the eclipse of a binary companion. Nearly 50 years ago, Harrington and Collins [2] modeled another way of breaking the symmetry and producing net polarization - the distortion of a rapidly rotating hot star. Here we report the first detection of this effect. Observations of the linear polarization of Regulus, with two different high-precision polarimeters, range from +42 parts-per-million (ppm) at a wavelength of 741 nm to -22 ppm at 395 nm. The reversal from red to blue is a distinctive feature of rotation-induced polarization. Using a new set of models for the polarization of rapidly rotating stars we find that Regulus is rotating at 96.5(+0.6/-0.8)% of its critical angular velocity for breakup, and has an inclination greater than 76.5 degrees. The rotation axis of the star is at a position angle of 79.5+/-0.7 degrees. The conclusions are independent of, but in good agreement with, the results of previously published interferometric observations of Regulus [3]. The accurate measurement of rotation in early-type stars is important for understanding their stellar environments [4], and course of their evolution [5].Peer reviewe
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