3D Face Recognition using Significant Point based SULD Descriptor

In this work, we present a new 3D face recognition method based on Speeded-Up Local Descriptor (SULD) of significant points extracted from the range images of faces. The proposed model consists of a method for extracting distinctive invariant features from range images of faces that can be used to perform reliable matching between different poses of range images of faces. For a given 3D face scan, range images are computed and the potential interest points are identified by searching at all scales. Based on the stability of the interest point, significant points are extracted. For each significant point we compute the SULD descriptor which consists of vector made of values from the convolved Haar wavelet responses located on concentric circles centred on the significant point, and where the amount of Gaussian smoothing is proportional to the radii of the circles. Experimental results show that the newly proposed method provides higher recognition rate compared to other existing contemporary models developed for 3D face recognition

Correlative study of sonological appearance of BI-RADS 4 and above breast lumps with histopathology and immunohistochemistry markers

Background: Breast cancer is clinically categorized into 4 major subtypes, ER (+), PR (+), Her2 (+), and TNBC. Although the correlation between sonographic features of breast cancer and immunohistochemistry markers expression is found, it is not still very clear; thus, this study aimed to investigate the ultrasound features of breast cancer and analyze the correlation between them. Methods: This was a prospective study, in which patients with breast lumps were sonologically categorized as BI-RADS 4 and above. Percutaneous biopsy was done. Histopathology and immunohistochemistry markers were correlated with ultrasound findings. Results: ER (+), PR (+) tumors were associated with irregular shape. ER (+), PR (+), and Her2 (+) tumors were associated with indistinct margin. TNBC tumor was associated with microlobulated margin. TNBC cases had more posterior acoustic enhancement. Conclusions: Young female with ultrasound features of oval/round shape, micro-lobulated margin, abrupt tumor interface, showing posterior acoustic enhancement, absence of microcalcification was significantly associated with TNBC.  Tumor with an irregular shape, indistinct margin, hyperechoic halo, no change in posterior acoustic feature, and presence of microcalcification were significantly associated with ER (+) cancers. Tumor with irregular shape, indistinct margin, and no change in the posterior acoustic feature was significantly associated with PR (+) cancers. Tumour with indistinct margin, and hyperechoic halo is significantly associated with Her2 (+) cancers. Tumor with irregular shape, indistinct margin, hyperechoic halo, and no posterior acoustic feature was associated with NTNBC

Genomic characterization of five deletions in the LDL receptor gene in Danish Familial Hypercholesterolemic subjects

BACKGROUND: Familial Hypercholesterolemia is a common autosomal dominantly inherited disease that is most frequently caused by mutations in the gene encoding the receptor for low density lipoproteins (LDLR). Deletions and other major structural rearrangements of the LDLR gene account for approximately 5% of the mutations in many populations. METHODS: Five genomic deletions in the LDLR gene were characterized by amplification of mutated alleles and sequencing to identify genomic breakpoints. A diagnostic assay based on duplex PCR for the exon 7 – 8 deletion was developed to discriminate between heterozygotes and normals, and bioinformatic analyses were used to identify interspersed repeats flanking the deletions. RESULTS: In one case 15 bp had been inserted at the site of the deleted DNA, and, in all five cases, Alu elements flanked the sites where deletions had occurred. An assay developed to discriminate the wildtype and the deletion allele in a simple duplex PCR detected three FH patients as heterozygotes, and two individuals with normal lipid values were detected as normal homozygotes. CONCLUSION: The identification of the breakpoints should make it possible to develop specific tests for these mutations, and the data provide further evidence for the role of Alu repeats in intragenic deletions

Glutathione S-transferase mu 1 (GSTM1) and theta 1 (GSTT1) genetic polymorphisms and atopic asthma in children from Southeastern Brazil

Xenobiotics can trigger degranulation of eosinophils and mast cells. In this process, the cells release several substances leading to bronchial hyperactivity, the main feature of atopic asthma (AA). GSTM1 and GSTT1 genes encode enzymes involved in the inactivation of these compounds. Both genes are polymorphic in humans and have a null variant genotype in which both the gene and corresponding enzyme are absent. An increased risk for disease in individuals with the null GST genotypes is therefore, but this issue is controversial. The aim of this study was to investigate the influence of the GSTM1 and GSTT1 genotypes on the occurrence of AA, as well as on its clinical manifestations. Genomic DNA from 86 patients and 258 controls was analyzed by polymerase chain reaction. The frequency of the GSTM1 null genotype in patients was higher than that found in controls (60.5% versus 40.3%, p = 0.002). In individuals with the GSTM1 null genotype the risk of manifested AA was 2.3-fold higher (95%CI: 1.4-3.7) than for others. In contrast, similar frequencies of GSTT1 null and combined GSTM1 plus GSTT1 null genotypes were seen in both groups. No differences in genotype frequencies were perceived in patients stratified by age, gender, ethnic origin, and severity of the disease. These results suggest that the inherited absence of the GSTM1 metabolic pathway may alter the risk of AA in southeastern Brazilian children, although this must be confirmed by further studies with a larger cohort of patients and age-matched controls from the distinct regions of the country

Association between COX-2 rs 6681231 Genotype and Interleukin-6 in Periodontal Connective Tissue. A Pilot Study

This study was partially undertaken at the UCL Eastman Dental Institute, which received a proportion of funding from the Department of Health’s National Institute of Health Research (NIHR) Biomedical Research Centres funding scheme