Skin friction in zero-pressure-gradient boundary layers

A global approach leading to a self-consistent solution to the Navier-Stokes-Prandtl equations for zero-pressure-gradient boundary layers is presented. It is shown that as $Re_{\delta}\rightarrow \infty$, the dynamically defined boundary layer thickness $\delta(x)\propto x/\ln^{2}Re_{x}$ and the skin friction $\lambda=\frac{2\tau_{w}}{\rho U_{0}^{2}}\propto 1/\ln^{2}\delta(x)$. Here $\tau_{w}$ and $U_{0}$ are the wall shear stress and free stream velocity, respectively. The theory is formulated as an expansion in powers of a small dimensionless parameter $\frac{d\delta(x)}{dx}\rightarrow 0$ in the limit $x\rightarrow \infty$

Is turbulent mixing a self convolution process ?

Experimental results for the evolution of the probability distribution function (PDF) of a scalar mixed by a turbulence flow in a channel are presented. The sequence of PDF from an initial skewed distribution to a sharp Gaussian is found to be non universal. The route toward homogeneization depends on the ratio between the cross sections of the dye injector and the channel. In link with this observation, advantages, shortcomings and applicability of models for the PDF evolution based on a self-convolution mechanisms are discussed.Comment: 4 page

Simulation of a particle-laden turbulent channel flow using an improved stochastic Lagrangian model

The purpose of this paper is to examine the Lagrangian stochastic modeling of the fluid velocity seen by inertial particles in a nonhomogeneous turbulent flow. A new Langevin-type model, compatible with the transport equation of the drift velocity in the limits of low and high particle inertia, is derived. It is also shown that some previously proposed stochastic models are not compatible with this transport equation in the limit of high particle inertia. The drift and diffusion parameters of these stochastic differential equations are then estimated using direct numerical simulation (DNS) data. It is observed that, contrary to the conventional modeling, they are highly space dependent and anisotropic. To investigate the performance of the present stochastic model, a comparison is made with DNS data as well as with two different stochastic models. A good prediction of the first and second order statistical moments of the particle and fluid seen velocities is obtained with the three models considered. Even for some components of the triple particle velocity correlations, an acceptable accordance is noticed. The performance of the three different models mainly diverges for the particle concentration and the drift velocity. The proposed model is seen to be the only one which succeeds in predicting the good evolution of these latter statistical quantities for the range of particle inertia studied

Characterization of All-Chromium Tunnel Junctions and Single Electron Tunneling Devices Fabricated by Direct-Writing Multilayer Technique

We report about the fabrication and analysis of the properties of Cr/CrO_x/Cr tunnel junctions and SET transistors, prepared by different variants of direct-writing multilayer technique. In all cases, the CrO_x tunnel barriers were formed in air under ambient conditions. From the experiments on single junctions, values for the effective barrier height and thickness were derived. For the Cr/CrO_x/Cr SET transistors we achieved minimal junction areas of 17 x 60 nm^2 using a scanning transmission electron microscope for the e-beam exposure on Si_3N_4 membrane substrate. We discuss the electrical performance of the transistor samples as well as their noise behavior.Comment: 19 pages, 9 figure

J004457+4123 (Sharov 21): not a remarkable nova in M31 but a background quasar with a spectacular UV flare

We announce the discovery of a quasar behind the disk of M31, which was previously classified as a remarkable nova in our neighbour galaxy. The paper is primarily aimed at the outburst of J004457+4123 (Sharov 21), with the first part focussed on the optical spectroscopy and the improvement in the photometric database. Both the optical spectrum and the broad band spectral energy distribution of Sharov 21 are shown to be very similar to that of normal, radio-quiet type 1 quasars. We present photometric data covering more than a century and resulting in a long-term light curve that is densely sampled over the past five decades. The variability of the quasar is characterized by a ground state with typical fluctuation amplitudes of ~0.2 mag around B~20.5, superimposed by a singular flare of ~2 yr duration (observer frame) with the maximum at 1992.81 where the UV flux has increased by a factor of ~20. The total energy in the flare is at least three orders of magnitudes higher than the radiated energy of the most luminous supernovae, provided that it comes from an intrinsic process and the energy is radiated isotropically. The profile of the flare light curve appears to be in agreement with the standard predictions for a stellar tidal disruption event where a ~10 M_sun giant star was shredded in the tidal field of a ~2...5 10^8 M_sun black hole. The short fallback time derived from the light curve requires an ultra-close encounter where the pericentre of the stellar orbit is deep within the tidal disruption radius. Gravitational microlensing provides an alternative explanation, though the probability of such a high amplification event is very low.Comment: Accepted for publication in Astronomy and Astrophysics, 14 pages, 11 figure

Reducing RBM20 activity improves diastolic dysfunction and cardiac atrophy

Impaired diastolic filling is a main contributor to heart failure with preserved ejection fraction (HFpEF), a syndrome with increasing prevalence and no treatment. Both collagen and the giant sarcomeric protein titin determine diastolic function. Since titin's elastic properties can be adjusted physiologically, we evaluated titin-based stiffness as a therapeutic target. We adjusted RBM20-dependent cardiac isoform expression in the titin N2B knockout mouse with increased ventricular stiffness. A ~50 % reduction of RBM20 activity does not only maintain cardiac filling in diastole but also ameliorates cardiac atrophy and thus improves cardiac function in the N2B-deficient heart. Reduced RBM20 activity partially normalized gene expression related to muscle development and fatty acid metabolism. The adaptation of cardiac growth was related to hypertrophy signaling via four-and-a-half lim-domain proteins (FHLs) that translate mechanical input into hypertrophy signals. We provide a novel link between cardiac isoform expression and trophic signaling via FHLs and suggest cardiac splicing as a therapeutic target in diastolic dysfunction. KEY MESSAGE: Increasing the length of titin isoforms improves ventricular filling in heart disease. FHL proteins are regulated via RBM20 and adapt cardiac growth. RBM20 is a therapeutic target in diastolic dysfunction

AMPA receptor anchoring at CA1 synapses is determined by N-terminal domain and TARP γ8 interactions.

AMPA receptor (AMPAR) abundance and positioning at excitatory synapses regulates the strength of transmission. Changes in AMPAR localisation can enact synaptic plasticity, allowing long-term information storage, and is therefore tightly controlled. Multiple mechanisms regulating AMPAR synaptic anchoring have been described, but with limited coherence or comparison between reports, our understanding of this process is unclear. Here, combining synaptic recordings from mouse hippocampal slices and super-resolution imaging in dissociated cultures, we compare the contributions of three AMPAR interaction domains controlling transmission at hippocampal CA1 synapses. We show that the AMPAR C-termini play only a modulatory role, whereas the extracellular N-terminal domain (NTD) and PDZ interactions of the auxiliary subunit TARP γ8 are both crucial, and each is sufficient to maintain transmission. Our data support a model in which γ8 accumulates AMPARs at the postsynaptic density, where the NTD further tunes their positioning. This interplay between cytosolic (TARP γ8) and synaptic cleft (NTD) interactions provides versatility to regulate synaptic transmission and plasticity

Decay of scalar variance in isotropic turbulence in a bounded domain

The decay of scalar variance in isotropic turbulence in a bounded domain is investigated. Extending the study of Touil, Bertoglio and Shao (2002; Journal of Turbulence, 03, 49) to the case of a passive scalar, the effect of the finite size of the domain on the lengthscales of turbulent eddies and scalar structures is studied by truncating the infrared range of the wavenumber spectra. Analytical arguments based on a simple model for the spectral distributions show that the decay exponent for the variance of scalar fluctuations is proportional to the ratio of the Kolmogorov constant to the Corrsin-Obukhov constant. This result is verified by closure calculations in which the Corrsin-Obukhov constant is artificially varied. Large-eddy simulations provide support to the results and give an estimation of the value of the decay exponent and of the scalar to velocity time scale ratio

Spontaneous Raman scattering for simultaneous measurements of in-cylinder species

A technique for multi-species mole fraction measurement in internal combustion engines is described. The technique is based on the spontaneous Raman scattering. It can simultaneously provide the mole fractions of several species of N-2, O-2, H2O, CO2 and fuel. Using the system, simultaneous measurement of air/fuel ratio and burnt residual gas are carried out during the mixture process in a Controlled Auto Ignition (CAI) combustion engine. The accuracy and consistency of the measured results were confirmed by the measured air fuel ratio using an exhaust gas analyzer and independently calculated mole fraction values. Measurement of species mole fractions during combustion process has also been demonstrated. It shows that the SRS can provide valuable data on this process in a CAI combustion engine

Shear Effects in Non-Homogeneous Turbulence

Motivated by recent experimental and numerical results, a simple unifying picture of intermittency in turbulent shear flows is suggested. Integral Structure Functions (ISF), taking into account explicitly the shear intensity, are introduced on phenomenological grounds. ISF can exhibit a universal scaling behavior, independent of the shear intensity. This picture is in satisfactory agreement with both experimental and numerical data. Possible extension to convective turbulence and implication on closure conditions for Large-Eddy Simulation of non-homogeneous flows are briefly discussed.Comment: 4 pages, 5 figure