Data Catalog Series for Space Science and Applications Flight Missions

The main purpose of the data catalog series is to provide descriptive references to data generated by space science flight missions. The data sets described include all of the actual holdings of the Space Science Data Center (NSSDC), all data sets for which direct contact information is available, and some data collections held and serviced by foreign investigators, NASA and other U.S. government agencies. This volume contains narrative descriptions of data sets from geostationary and high altitude scientific spacecraft and investigations. The following spacecraft series are included: Mariner, Pioneer, Pioneer Venus, Venera, Viking, Voyager, and Helios. Separate indexes to the planetary and interplanetary missions are also provided

Non-invasive assessment of pulmonary vascular resistance in pulmonary hypertension: Current knowledge and future direction

Pulmonary Hypertension (PHT) is relatively common, dangerous and under-recognised. Pulmonary hypertension is not a diagnosis in itself; it is caused by a number of differing diseases each with different treatments and prognoses. Therefore, timely and accurate recognition of the underlying cause for PHT is essential for appropriate management. This is especially true for patients with Pulmonary Arterial Hypertension (PAH) in the current era of disease-specific drug therapy. Measurement of Pulmonary Vascular Resistance (PVR) helps separate pre-capillary from post-capillary PHT, and is measured with right heart catheterisation (RHC). Echocardiography has been used to derive a number of non-invasive surrogates for PVR, with varying accuracy. Ultimately, the goal of non-invasive assessment of PVR is to separate PHT due to left heart disease from PHT due to increased PVR, to help streamline investigation and subsequent treatment. In this review, we summarise the physiology and pathophysiology of pulmonary blood flow, the various causes of pulmonary hypertension, and non-invasive surrogates for PVR

A multi-agent based system to enable strategic and operational design coordination

This paper presents two systems which individually focus on different aspects of design coordination, namely strategic and operational. The systems were developed in parallel and individually contain related models that represent specific frames from a Design Coordination Framework developed by Andreasen et al. [1]. The focus of the strategic design management system is the management of design tasks, decisions, information, goals and rationale within the design process, whereas the focus of the operational design coordination system is the coordination of tasks and activities with respect to the near-optimal utilisation of available resources. A common interface exists which enables the two systems to be integrated and used as a single system with the aim of managing both strategicand operational design coordination. Hence, the objective of this work is to enable the design process to be conducted in a timely and appropriate manner

Protocol: optimised electrophyiological analysis of intact guard cells from arabidopsis

Genetic resources available for Arabidopsis thaliana make this species particularly attractive as a model for molecular genetic studies of guard cell homeostasis, transport and signalling, but this facility is not matched by accessible tools for quantitative analysis of transport in the intact cell. We have developed a reliable set of procedures for voltage clamp analysis of guard cells from Arabidopsis leaves. These procedures greatly simplify electrophysiological recordings, extending the duration of measurements and scope for analysis of the predominant K+ and anion channels of intact stomatal guard cells to that achieved previously in work with Vicia and tobacco guard cells

Coordination approaches and systems - part II : an operational perspective

This is the second of two papers surveying research in coordination approaches and systems. This paper is concerned with operational coordination, which is aimed at coordinating activities such that the design process can be performed in a near optimal manner with respect to time, and the allocation and utilisation of resources. Aspects of coordination categorised as operational include resource management, scheduling and planning. The first of these two papers presents a review of coordination from a strategic perspective, which is concerned with the decision management aspects of coordination. Greater emphasis is now being placed on the significance of organising the design process as this affects time to market, product quality, cost, and consequently product success. The aim of this paper is to present a fundamental review of operational coordination approaches and systems. The 1990s has seen much progress being made towards a greater understanding and appreciation of coordination in various disciplines through the development of a wide range of approaches and systems. However, there remains a requirement to formally identify the key issues involved in coordination such that a widely accepted representation can be agreed upon. Consequently, research should continue to be supported in the exploration for a unified approach to coordination which will permit a broader and greater understanding of those aspects involved

A system for co-ordinating concurrent engineering

Design of large made-to-order products invariably involves design activities which are increasingly being distributed globally in order to reduce costs, gain competitive advantage and utilise external expertise and resources. Designers specialise within their domain producing solutions to design problems using the tools and techniques with which they are familiar. They possess a relatively local perception of where their expertise and actions are consumed within the design process. This is further compounded when design activities are geographically distributed, resulting with the increased disassociation between an individual designer's activities and the overall design process. The tools and techniques used by designers rarely facilitate concurrency, producing solutions within a particular discipline without using or sharing information from other disciplines, and seldom considering stages within the product's life-cycle other than conceptual, embodiment or detail [1, 2]. Conventional management and maintenance of consistency throughout the product model can subsequently become difficult to achieve since there are many factors that need to be simultaneously considered whilst making achange to the product model

Coordination approaches and systems - part I : a strategic perspective

This is the first part of a two-part paper presenting a fundamental review and summary of research of design coordination and cooperation technologies. The theme of this review is aimed at the research conducted within the decision management aspect of design coordination. The focus is therefore on the strategies involved in making decisions and how these strategies are used to satisfy design requirements. The paper reviews research within collaborative and coordinated design, project and workflow management, and, task and organization models. The research reviewed has attempted to identify fundamental coordination mechanisms from different domains, however it is concluded that domain independent mechanisms need to be augmented with domain specific mechanisms to facilitate coordination. Part II is a review of design coordination from an operational perspective

Vitamin B12 measurements across neurodegenerative disorders.

Background:Vitamin B12 deficiency causes a number of neurological features including cognitive and psychiatric disturbances, gait instability, neuropathy, and autonomic dysfunction. Clinical recognition of B12 deficiency in neurodegenerative disorders is more challenging because it causes defects that overlap with expected disease progression. We sought to determine whether B12 levels at the time of diagnosis in patients with Parkinson's disease (PD) differed from those in patients with other neurodegenerative disorders. Methods:We performed a cross-sectional analysis of B12 levels obtained around the time of diagnosis in patients with PD, Multiple System Atrophy (MSA), Dementia with Lewy Bodies (DLB), Alzheimer's disease (AD), Progressive Supranuclear Palsy (PSP), Frontotemporal Dementia (FTD), or Mild Cognitive Impairment (MCI). We also evaluated the rate of B12 decline in PD, AD, and MCI. Results:In multivariable analysis adjusted for age, sex, and B12 supplementation, we found that B12 levels were significantly lower at time of diagnosis in patients with PD than in patients with PSP, FTD, and DLB. In PD, AD, and MCI, the rate of B12 decline ranged from - 17 to - 47 pg/ml/year, much greater than that reported for the elderly population. Conclusions:Further studies are needed to determine whether comorbid B12 deficiency affects progression of these disorders

Assessment worlds colliding? Negotiating between discourses of assessment on an online open course

Using the badged open course, Taking your first steps into Higher Education, this case study examines how assessment on online open courses draws on concepts of assessment used within formal and informal learning. Our experience was that assessment used within open courses, such as massive open online courses, is primarily determined by the requirements of quality assurance processes to award a digital badge or statement of participation as well as what is technologically possible. However, this disregards much recent work in universities that use assessment in support of learning. We suggest that designers of online open courses should pay greater attention to the relationship of assessment and learning to improve participant course completion

Rotary Honing: a Variant of the Taylor Paint-Scraper Problem

The three-dimensional Row in a corner of fixed angle α induced by the rotation in its plane of one of the boundaries is considered. A local similarity solution valid in a neighbourhood of the centre of rotation is obtained and the streamlines are shown to be closed curves. The effects of inertia are considered and are shown to be significant in a small neighbourhood of the plane of symmetry of the flow. A simple experiment confirms that the streamlines are indeed nearly closed; their projections on planes normal to the line of intersection of the boundaries are precisely the \u27Taylor\u27 streamlines of the well-known \u27paint-scraper\u27 problem. Three geometrical variants are considered: (i) when the centre of rotation of the lower plate is offset from the contact line; (ii) when both planes rotate with different angular velocities about a vertical axis and Coriolis effects are retained in the analysis; and (iii) when two vertical planes intersecting at an angle 2β are honed by a rotating conical boundary. The last is described by a similarity solution of the first kind (in the terminology of Barenblatt) which incorporates within its structure a similarity solution of the second kind involving corner eddies of a type familiar in two-dimensional corner flows