Fisher profiles and perceptions of sea turtle-fishery interactions: case study of East Coast Peninsular Malaysia

The paper focuses on coastal fisheries, particularly examining sea turtle-fishery interactions and determining the socioeconomic profile and perception of local fishers about sea turtle issues along the East Coast of Peninsular Malaysia.Turtle fisheries, Nature conservation, Coastal fisheries, Man-induced effects, ISEW, Malaysia, Malaya, Pahang, Malaysia, Malaya, Kelantan, Malaysia, Malaya, Terengganu,

Kartlegging av levekårene til personer med utviklingshemming i samiske områder

Publikasjonen er en rapport fra en undersøkelse av levekårene til personer med utviklingshemming i de samiske forvaltningskommunene, samt enkelte andre kommuner i Nord-Norge, gjennomført av Avdeling vernepleie ved UiT våren 2017. Undersøkelsen ble gjennomført på oppdrag fra Barne-, ungdoms- og familiedirektoratet (Bufdir) og Nordens velferdssenter (NVC). 93 personer mellom 16 og 76 år svarte på undersøkelsen. En tredjedel av utvalget hadde samisk bakgrunn. Det ble undersøkt om det er forskjeller i levekårene til personer i samiske områder med og uten samiske bakgrunn, samt at levekårene til personer i samiske områder ble sammenliknet med levekårene til personer med utviklingshemming generelt og med levekårene til befolkningen for øvrig. Undersøkelsen fokuserte på levekårs- og livskvalitetsdimensjonene skole/utdanning, aktivitet på dagtid, boforhold, sosialt nettverk, helse og hjelpebehov, fritid, demokratisk deltakelse, tilfredshet, selvbestemmelse og mobbing. Studien var den første i Norge som undersøkte betydningen av samisk bakgrunn for levekårene til personer med utviklingshemming. Det var også er den første levekårsundersøkelsen personer med utviklingshemming selv har fått mulighet til å besvare. På bakgrunn av funnene i studien kommer forfatterne med følgende anbefalinger: • Økt fokus på mobbing, trusler og vold mot personer med utviklingshemming generelt, og mot de med samisk bakgrunn spesielt, både i hverdagen på ulike livsarenaer, og juridisk innenfor rettsapparatet. • Økt fokus på forebygging og behandling av psykiske helseplager hos personer med utviklingshemming generelt, og hos de med samisk bakgrunn spesielt. • Økt fokus på organisering av botilbud og øvrige tjenester til personer med utviklingshemming, for å redusere standardisering av levesett, og gi økt selvbestemmelse og mulighet til å delta i samfunnet på linje med befolkningen ellers

Cyclic AMP induces IPC leukemia cell apoptosis via CRE-and CDK-dependent Bim transcription

The IPC-81 cell line is derived from the transplantable BNML model of acute myelogenic leukemia (AML), known to be a reliable predictor of the clinical efficiency of antileukemic agents, like the first-line AML anthracycline drug daunorubicin (DNR). We show here that cAMP acted synergistically with DNR to induce IPC cell death. The DNR-induced death differed from that induced by cAMP by (1) not involving Bim induction, (2) being abrogated by GSK3β inhibitors, (3) by being promoted by the HSP90/p23 antagonist geldanamycin and truncated p23 and (4) by being insensitive to the CRE binding protein (CREB) antagonist ICER and to cyclin-dependent protein kinase (CDK) inhibitors. In contrast, the apoptosis induced by cAMP correlated tightly with Bim protein expression. It was abrogated by Bim (BCL2L11) downregulation, whether achieved by the CREB antagonist ICER, by CDK inhibitors, by Bim-directed RNAi, or by protein synthesis inhibitor. The forced expression of BimL killed IPC-81WT cells rapidly, Bcl2-overexpressing cells being partially resistant. The pivotal role of CREB and CDK activity for Bim transcription is unprecedented. It is also noteworthy that newly developed cAMP analogs specifically activating PKA isozyme I (PKA-I) were able to induce IPC cell apoptosis. Our findings support the notion that AML cells may possess targetable death pathways not exploited by common anti-cancer agents

Arbeid, arbeidere og arbeiderbevegelse på Agder 1500–2020

Agder was and is an important industrial and working-class county. Wasn't it in Arendal that the Norwegian Labor Party was founded? Isn't it the case that a number of eloquent agitators, ideologues and strategists come from the South? It's not a guess that Kristiansand is new Houston? This book will help bring work, the workers and the labor movement in Agder out of oblivion. Eight authors take us through working life in Southern Norway between 1500 and 2020. The history of industrial work in Sørlandet is proud and varied: There was shipbuilding and ironworks operation, steam engines and mechanical workshops, textile industry, breweries and bakeries before 1900. Around the turn of the century, the region gained large jobs in wood processing and the electrometallurgical industry. In the 20th century, these were supplemented by many small and medium-sized businesses. And in recent times there has been another increase, with industrial work in shipbuilding and the oil industry. This anthology deals with the history of work, workers and the labor movement and also concerns challenges, conflicts and cooperation. As several of the contributions in the book show, it happened that Sørlandet's underclass took a strong stand against the authorities and employers. Labour, the workers and the labor movement in Agder not only have a past, but also a present. Two of the contributions shed light on current topics such as labor migration in and out of Agder, neoliberalism and trade union work in Agder. The chapters in the book are relevant for both researchers and lay people, not least from the labor movement, from Agder and other parts of the country

Hand-assisted retroperitoneoscopic versus standard laparoscopic donor nephrectomy: HARP-trial

Contains fulltext : 88436.pdf (publisher's version ) (Open Access)BACKGROUND: Transplantation is the only treatment offering long-term benefit to patients with chronic kidney failure. Live donor nephrectomy is performed on healthy individuals who do not receive direct therapeutic benefit of the procedure themselves. In order to guarantee the donor's safety, it is important to optimise the surgical approach. Recently we demonstrated the benefit of laparoscopic nephrectomy experienced by the donor. However, this method is characterised by higher in hospital costs, longer operating times and it requires a well-trained surgeon. The hand-assisted retroperitoneoscopic technique may be an alternative to a complete laparoscopic, transperitoneal approach. The peritoneum remains intact and the risk of visceral injuries is reduced. Hand-assistance results in a faster procedure and a significantly reduced operating time. The feasibility of this method has been demonstrated recently, but as to date there are no data available advocating the use of one technique above the other. METHODS/DESIGN: The HARP-trial is a multi-centre randomised controlled, single-blind trial. The study compares the hand-assisted retroperitoneoscopic approach with standard laparoscopic donor nephrectomy. The objective is to determine the best approach for live donor nephrectomy to optimise donor's safety and comfort while reducing donation related costs. DISCUSSION: This study will contribute to the evidence on any benefits of hand-assisted retroperitoneoscopic versus standard laparoscopic donor nephrectomy. TRIAL REGISTRATION: Dutch Trial Register NTR1433

Tyrosine kinase inhibitor therapy-induced changes in humoral immunity in patients with chronic myeloid leukemia

Purpose Tyrosine kinase inhibitors (TKIs) have well-characterized immunomodulatory effects on T and NK cells, but the effects on the humoral immunity are less well known. In this project, we studied TKI-induced changes in B cell-mediated immunity. Methods We collected peripheral blood (PB) and bone marrow (BM) samples from chronic myeloid leukemia (CML) patients before and during first-line imatinib (n = 20), dasatinib (n = 16), nilotinib (n = 8), and bosutinib (n = 12) treatment. Plasma immunoglobulin levels were measured, and different B cell populations in PB and BM were analyzed with flow cytometry. Results Imatinib treatment decreased plasma IgA and IgG levels, while dasatinib reduced IgM levels. At diagnosis, the proportion of patients with IgA, IgG, and IgM levels below the lower limit of normal (LLN) was 0, 11, and 6% of all CML patients, respectively, whereas at 12 months timepoint the proportions were 6% (p = 0.13), 31% (p = 0.042) and 28% (p = 0.0078). Lower initial Ig levels predisposed to the development of hypogammaglobulinemia during TKI therapy. Decreased Ig levels in imatinibtreated patients were associated with higher percentages of immature BM B cells. The patients, who had low Ig levels during the TKI therapy, had significantly more frequent minor infections during the follow-up compared with the patients with normal Ig values (33% vs. 3%, p = 0.0016). No severe infections were reported, except recurrent upper respiratory tract infections in one imatinib-treated patient, who developed severe hypogammaglobulinemia. Conclusions TKI treatment decreases plasma Ig levels, which should be measured in patients with recurrent infections.Peer reviewe

Statistical analysis of arthroplasty data: II. Guidelines

It is envisaged that guidelines for statistical analysis and presentation of results will improve the quality and value of research. The Nordic Arthroplasty Register Association (NARA) has therefore developed guidelines for the statistical analysis of arthroplasty register data. The guidelines are divided into two parts, one with an introduction and a discussion of the background to the guidelines (Ranstam et al. 2011a, see pages x-y in this issue), and this one with a more technical statistical discussion on how specific problems can be handled. This second part contains (1) recommendations for the interpretation of methods used to calculate survival, (2) recommendations on howto deal with bilateral observations, and (3) a discussion of problems and pitfalls associated with analysis of factors that influence survival or comparisons between outcomes extracted from different hospitals

Immunotherapy with allotumour mRNA-transfected dendritic cells in androgen-resistant prostate cancer patients

Here, we present results from a clinical trial employing a new vaccination method using dendritic cells (DCs) transfected with mRNA from allogeneic prostate cancer cell lines (DU145, LNCaP and PC-3). In all, 20 patients were enrolled and 19 have completed vaccination. Each patient received at least four weekly injections with 2 × 107 transfected DCs either intranodally or intradermally. Safety and feasibility of vaccination were determined. Immune responses were measured as delayed-type hypersensitivity and by in vitro immunoassays including ELISPOT and T-cell proliferation in pre- and postvaccination peripheral blood samples. Serum prostate-specific antigen (PSA) levels and bone scans were monitored. No toxicity or serious adverse events related to vaccinations were observed. A total of 12 patients developed a specific immune response to tumour mRNA-transfected DCs. In total, 13 patients showed a decrease in log slope PSA. This effect was strengthened by booster vaccinations. Clinical outcome was significantly related to immune responses (n=19, P=0.002, r=0.68). Vaccination with mRNA-transfected DCs is safe and results in cellular immune responses specific for antigens encoded by mRNA derived from the prostate cancer cell lines. The observation that in some patients vaccination affected the PSA level suggests that this approach may become useful as a treatment modality for prostate cancer patients