The perception of the autonomy supportive behaviour as a predictor of perceived effort and physical self-esteem among school students from four nations

Grounded in self-determination theory (SDT), this study tested a model of motivational sequence in which perceived autonomy support from teachers in a physical education (PE) context predicted the perceived effort and physical self-esteem via self-determined motivation in school students. School students aged 12 to 16 years from Estonia (N = 816), Lithuania (N = 706), Hungary (N = 664), and Spain (N = 922) completed measures of perceived autonomy support from PE teachers, need satisfaction for autonomy, competence, relatedness, self-determined motivation, perceived effort and physical self-esteem. The results of the structural equation model (SEM) of each sample indicated that the students’ perceived autonomy support from the teacher was directly related to effort and indirectly via autonomous motivation, whereas physical self-esteem was related indirectly. Confirmatory factor analyses and multi-sample structural equation revealed well-fitting models within each sample with the invariances of the measurement parameters across four nations. The findings support the generalizability of the measures in the motivational sequence model to predict perceived effort and physical self-estee

Subconjunctival delivery of p75NTR antagonists reduces the inflammatory, vascular, and neurodegenerative pathologies of diabetic retinopathy

The p75NTR is a novel therapeutic target validated in a streptozotocin mouse model of diabetic retinopathy. Intravitreal (IVT) injection of small molecule p75NTR antagonist THX-B was therapeutic and resolved the inflammatory, vascular, and neurodegenerative phases of the retinal pathology. To simplify clinical translation, we sought a superior drug delivery method that circumvents risks associated with IVT injections. METHODS. We compared the pharmacokinetics of a single 40 lg subconjunctival (SCJ) depot to the reported effective 5 lg IVT injections of THX-B. We quantified therapeutic efficacy, with endpoints of inflammation, edema, and neuronal death. RESULTS. The subconjunctival depot affords retinal exposure equal to IVT injection, without resulting in detectable drug in circulation. At week 2 of diabetic retinopathy, the SCJ depot provided therapeutic efficacy similar to IVT injections, with reduced inflammation, reduced edema, reduced neuronal death, and a long-lasting protection of the retinal structure. CONCLUSIONS. Subconjunctival injections are a safe and effective route for retinal delivery of p75NTR antagonists. The subconjunctival route offers an advantageous, less-invasive, more compliant, and nonsystemic method to deliver p75NTR antagonists for the treatment of retinal diseases.Fil: Galan, Alba. Mc Gill University. Lady Davis Research Intitute; CanadáFil: Barcelona, Pablo Federico. Mc Gill University. Lady Davis Research Intitute; Canadá. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Nedev, Hinyu. Mc Gill University. Lady Davis Research Intitute; CanadáFil: Sarunic, Marinko V.. University Fraser Simon; CanadáFil: Jian, Yifan. University Fraser Simon; CanadáFil: Saragovi, H. Uri. Mc Gill University. Lady Davis Research Intitute; Canad

Modulating Flow Topology in Microdroplets to Control Reaction Kinetics

In traditional reaction flasks, the reaction rate of macromolecular compounds is dictated by the concentrations and distribution of reactants along with their intrinsic reaction kinetics. Controlling reaction kinetics in microfluidic droplets has been proposed through the regulation of flow dynamics, but is yet to be demonstrated experimentally. Here, this hypothesis is verified by accelerating or suppressing macromolecular reactant mixing in microfluidic droplets. The control of reaction kinetics through the modulation of flow topology in microdroplets may enable further developments in modeling macromolecular systems

Testing the Evolution of the Correlations between Supermassive Black Holes and their Host Galaxies using Eight Strongly Lensed Quasars

One of the main challenges in using high redshift active galactic nuclei to study the correlations between the mass of the supermassive Black Hole (MBH) and the properties of their active host galaxies is instrumental resolution. Strong lensing magnification effectively increases instrumental resolution and thus helps to address this challenge. In this work, we study eight strongly lensed active galactic nuclei (AGN) with deep Hubble Space Telescope imaging, using the lens modelling code Lenstronomy to reconstruct the image of the source. Using the reconstructed brightness of the host galaxy, we infer the host galaxy stellar mass based on stellar population models. MBH are estimated from broad emission lines using standard methods. Our results are in good agreement with recent work based on non-lensed AGN, demonstrating the potential of using strongly lensed AGNs to extend the study of the correlations to higher redshifts. At the moment, the sample size of lensed AGN is small and thus they provide mostly a consistency check on systematic errors related to resolution for the non-lensed AGN. However, the number of known lensed AGN is expected to increase dramatically in the next few years, through dedicated searches in ground and space based wide field surveys, and they may become a key diagnostic of black hole and galaxy co-evolution.Comment: 12 pages, 4 figures, 3 tables. MNRAS in press. Comments welcom