3-Ethyl-6-(4-fluoro­phen­yl)-7H-1,2,4-triazolo[3,4-b][1,3,4]thia­diazine

In the title compound, C12H11FN4S, the thia­diazine ring adopts a twist-boat conformation. The dihedral angle between the triazolothia­diazine system and the benzene ring is 10.54 (9)°. The crystal structure is characterized by C—H⋯N hydrogen bonds. The crystal packing also exhibits π–π inter­actions, with a centroid–centroid distance of 3.6348 (15) Å

Preon Prophecies by the Standard Model

The Standard Model of quarks and leptons is, at first sight, nothing but a set of {\it ad hoc} rules, with no connections, and no clues to their true background. At a closer look, however, there are many inherent prophecies that point in the same direction: {\it Compositeness} in terms of three stable preons.Comment: 13 pages, 8 eps-figures, invited talk at Beyond the Desert '03, Schloss Ringberg, Bavaria, June 2003; to be published in the Proceeding

Environmental and genetic influences on neurocognitive development: the importance of multiple methodologies and time-dependent intervention

Genetic mutations and environmental factors dynamically influence gene expression and developmental trajectories at the neural, cognitive, and behavioral levels. The examples in this article cover different periods of neurocognitive development—early childhood, adolescence, and adulthood—and focus on studies in which researchers have used a variety of methodologies to illustrate the early effects of socioeconomic status and stress on brain function, as well as how allelic differences explain why some individuals respond to intervention and others do not. These studies highlight how similar behaviors can be driven by different underlying neural processes and show how a neurocomputational model of early development can account for neurodevelopmental syndromes, such as autism spectrum disorders, with novel implications for intervention. Finally, these studies illustrate the importance of the timing of environmental and genetic factors on development, consistent with our view that phenotypes are emergent, not predetermined

Detailed Analysis of the Solution Heat Treatment of a Third-Generation Single-Crystal Nickel-Based Superalloy CMSX-10K^®

Abstract A detailed analysis of the response of as-cast third-generation single-crystal nickel-based superalloy CMSX-10K® to solution heat treatment (SHT) has been carried out, alongside an SHT optimization exercise. The analysis was conducted through microstructural characterization, differential scanning calorimetry, and compositional homogeneity measurements, quantifying (i) the dissolution and microstructural evolution of the inter-dendritic constituents, (ii) the shift in thermo-physical characteristics of the material, and (iii) the change in compositional homogeneity across the microstructure, in order to gain further understanding of these phenomena during the progression of the SHT. During the early stages of SHT, the coarse cellular γ′/narrow γ channel inter-dendritic constituents which were the last areas to solidify during casting, progressively dissolve; homogenization between these inter-dendritic areas and adjacent dendritic areas leads to a rapid increase in the incipient melting temperature T IM. The fine γ/γ′ morphology which were the first inter-dendritic constituents to solidify after primary γ dendrite solidification were found to progressively coarsen; however, subsequent dissolution of these coarsened γ/γ′ inter-dendritic areas did not result in significant increases in the T IM until the near-complete dissolution of these inter-dendritic areas. After the final SHT step, residual compositional micro-segregation could still be detected across the microstructure despite the near-complete dissolution of these remnant inter-dendritic areas; even so the T IM of the material approached the solidus temperature of the alloy.The authors would like to acknowledge funding through the EPSRC/Rolls-Royce Strategic Partnership (EP/H500375/1 and EP/M005607/1). The authors also wish to express appreciation to Dr. Chris Hayward at the School of Geosciences, University of Edinburgh for carrying out the EPMA composition measurements and to Mr. Kevin Roberts of Dept. of Materials Science and Metallurgy for assistance in carrying out the solution heat treatment runs. Requests for access to the underlying research data should be directed to the corresponding author and will be considered against commercial interests and data protection.This is the final version of the article. It was first available from Springer via http://dx.doi.org/10.1007/s11661-015-3252-

1-(1-Benzofuran-2-yl)-3-(4-chloro­phen­yl)prop-2-en-1-one

In the title compound, C17H11ClO2, the benzofuran ring system is almost planar (r.m.s. deviation = 0.011 Å) and forms a dihedral angle of 10.53 (6)° with the chloro­phenyl ring. No significant inter­molecular inter­actions are observed

Network Growth with Feedback

Existing models of network growth typically have one or two parameters or strategies which are fixed for all times. We introduce a general framework where feedback on the current state of a network is used to dynamically alter the values of such parameters. A specific model is analyzed where limited resources are shared amongst arriving nodes, all vying to connect close to the root. We show that tunable feedback leads to growth of larger, more efficient networks. Exact results show that linear scaling of resources with system size yields crossover to a trivial condensed state, which can be considerably delayed with sublinear scaling.Comment: 4 pages, 4 figure

Long and short paths in uniform random recursive dags

In a uniform random recursive k-dag, there is a root, 0, and each node in turn, from 1 to n, chooses k uniform random parents from among the nodes of smaller index. If S_n is the shortest path distance from node n to the root, then we determine the constant \sigma such that S_n/log(n) tends to \sigma in probability as n tends to infinity. We also show that max_{1 \le i \le n} S_i/log(n) tends to \sigma in probability.Comment: 16 page