Binary mixture efficacy of NeemAzal and Plectranthus glandulosus leaf powder against cowpea and maize weevils: Poster

The aim of this study was to determine the insecticidal efficacy of mixture of NeemAzal a commercial neem product and Plectranthus glandulosus leaf powder against Callosubruchus maculatus and Sitophilus zeamais. Mixed at various proportions (100 + 0, 75 + 25, 50 + 50, 25 + 75 and 0 +100%, these powders were tested on adult mortality, inhibition of offspring production and their persistence on C. maculatus and S. zeamais. All the mixed NeemAzal and P. glandulosus caused significant mortality to adult C. maculatus and S. zeamais. No significant difference was observed among the mixed powders that were subjected to the three mixture proportions regarding the mortality they caused to the weevils. The mixed 75% NeemAzal + 25% P .glandulosus of powder led to a higher mortality (100%) of both insect species, three (5 g/kg) days post exposure. The three days LC50 values decreased with ascending proportion of NeemAzal in the mixture from 3.21 g/kg (25% NeemAzal + 75% P. glandulosus) to 0.24 g/kg (75% NeemAzal + 25% P. glandulosus) in S. zeamais. In C. maculatus, the opposing effect was observed. The number of F1 progeny produced reduced significantly (P = 0.01) in both insect species with the mixture proportion of botanicals. The mixtures reduced better the adult progeny production than the botanicals applied alone. The 75% P. glandulosus + 25% NeemAzal persisted well on grains up to 180 days for all dose levels. Powder from NeemAzal and P. glandulosus leaves stand as good candidates to protect maize and cowpea against the infestation of S. zeamais and C. maculatus respectively during storage. Mixing these products could not be advantageous since the binary mixture gave similar result as when they were applied alone.The aim of this study was to determine the insecticidal efficacy of mixture of NeemAzal a commercial neem product and Plectranthus glandulosus leaf powder against Callosubruchus maculatus and Sitophilus zeamais. Mixed at various proportions (100 + 0, 75 + 25, 50 + 50, 25 + 75 and 0 +100%, these powders were tested on adult mortality, inhibition of offspring production and their persistence on C. maculatus and S. zeamais. All the mixed NeemAzal and P. glandulosus caused significant mortality to adult C. maculatus and S. zeamais. No significant difference was observed among the mixed powders that were subjected to the three mixture proportions regarding the mortality they caused to the weevils. The mixed 75% NeemAzal + 25% P .glandulosus of powder led to a higher mortality (100%) of both insect species, three (5 g/kg) days post exposure. The three days LC50 values decreased with ascending proportion of NeemAzal in the mixture from 3.21 g/kg (25% NeemAzal + 75% P. glandulosus) to 0.24 g/kg (75% NeemAzal + 25% P. glandulosus) in S. zeamais. In C. maculatus, the opposing effect was observed. The number of F1 progeny produced reduced significantly (P = 0.01) in both insect species with the mixture proportion of botanicals. The mixtures reduced better the adult progeny production than the botanicals applied alone. The 75% P. glandulosus + 25% NeemAzal persisted well on grains up to 180 days for all dose levels. Powder from NeemAzal and P. glandulosus leaves stand as good candidates to protect maize and cowpea against the infestation of S. zeamais and C. maculatus respectively during storage. Mixing these products could not be advantageous since the binary mixture gave similar result as when they were applied alone

Applicability of the National Comprehensive Cancer Network/Multinational Association of Supportive Care in Cancer Guidelines for Prevention and Management of Chemotherapy-Induced Nausea and Vomiting in Southeast Asia: A Consensus Statement.

A meeting of regional experts was convened in Manila, Philippines, to develop a resource-stratified chemotherapy-induced nausea and vomiting (CINV) management guideline. In patients treated with highly emetogenic chemotherapy in general clinical settings, triple therapy with a serotonin (5-hydroxytryptamine-3 [5-HT3]) antagonist (preferably palonosetron), dexamethasone, and aprepitant is recommended for acute CINV prevention. In resource-restricted settings, triple therapy is still recommended, although a 5-HT3 antagonist other than palonosetron may be used. In both general and resource-restricted settings, dual therapy with dexamethasone (days 2 to 4) and aprepitant (days 2 to 3) is recommended to prevent delayed CINV. In patients treated with moderately emetogenic chemotherapy, dual therapy with a 5-HT3 antagonist, preferably palonosetron, and dexamethasone is recommended for acute CINV prevention in general settings; any 5-HT3 antagonist can be combined with dexamethasone in resource-restricted environments. In general settings, for the prevention of delayed CINV associated with moderately emetogenic chemotherapy, corticosteroid monotherapy on days 2 and 3 is recommended. If aprepitant is used on day 1, it should be continued on days 2 and 3. Prevention of delayed CINV with corticosteroids is preferred in resource-restricted settings. The expert panel also developed CINV management guidelines for anthracycline plus cyclophosphamide combination schedules, multiday cisplatin, and chemotherapy with low or minimal emetogenic potential, and its recommendations are detailed in this review. Overall, these regional guidelines provide definitive guidance for CINV management in general and resource-restricted settings. These consensus recommendations are anticipated to contribute to collaborative efforts to improve CINV management in Southeast Asia

Birth defect and risk factor surveillance in the northern and southwestern Netherlands

Objective: To survey the associations between several risk factors and birth defects, in order to detect potential new teratogens.Methods: Data of the two Dutch European Registration of Congenital Anomalies (EUROCAT) registries collected before January 1, 1998 were used to perform X2 tests for a large number of risk factors and birth defects. Defects caused by chromosomal or monogenic disorders were analyzed separately.Results: Cross- tabulations of 80 groups of birth defects with 303 risk factors were studied. Of these, 126 combinations had a p value under 0.05, and 34 had a p value under 0.001. Of these 34 associations, some are known in the literature, some were found before in the same databases and some were new associations.Conclusions: This is a good method for generating new hypotheses for associations between risk factors and birth defects. It can be a start for new, more in-depth studies of potential teratogens. Copyright (C) 2000 S. Karger AG, Basel.</p

A PROPOSAL FOR A HYBRID POWER TRAIN FOR A TRUCK

Aiming at reducing the emission of pollutants from automotive vehicles, international commissions indicate, at each given period, a target of admissible values for these pollutants, to be implemented by the automakers. A case like the future implementation of EuroVII, from 2025, in European regions. In parallel to these conditions, there are many studies with the objective of seeking alternatives for the propulsion of these combustion vehicles, for example, the application of fully electric or hybrid vehicles. This article aims to develop and implement a mathematical model for a proposal for a hybrid engine, in a low-power truck, resulting in a small diesel engine, powering the vehicle's alternator and battery, generating the charging for use in a main electric motor, that is, to develop with a focus on energy conservation and the environment, with a reduction in the size of a combustion engine and its emissions

GRACE and TIMI risk scores but not stress imaging predict long-term cardiovascular follow-up in patients with chest pain after a rule-out protocol

Objective To determine the long-term prognostic value of stress imaging and clinical risk scoring for cardiovascular mortality in chest pain patients after ruling out acute coronary syndrome (ACS). Methods A standard rule-out protocol was performed in emergency room patients with a normal or non-diagnostic admission electrocardiogram (ECG) within 6 h of chest 4 pain onset. ACS patients were identified by troponin T, recurrent angina and serial ECG. Dobutamine stress echocardiography (DSE) was performed after ACS was ruled out. Myocardial perfusion scintigraphy (MPS) was performed within 6 months in an outpatient setting according to the physician's discretion. Results 524 patients were included. GRACE and TIMI risk scores were 75 (57-96) and 1 (0-2) in the rule-out ACS group, and 89 (74-107) and 2 (1-3) in the ACS group, respectively (median, interquartile range). Follow-up (median 9.4 (8.9-10.0) years) was complete in 96%. 350 of 379 rule-out ACS patients had an interpretable DSE and 52 patients underwent an MPS. 21 of the rule-out ACS patients (6%) died of a cardiovascular cause compared with 24 (17%) ACS patients (p <0.001). For rule-out ACS patients, C-statistics were 0.829 and 0.803 for the GRACE and TIMI scores. In these patients, DSE and MPS outcome did not predict long-term cardiovascular mortality. In multivariate analysis, known chronic heart failure, ACE inhibitor use, and GRACE score were independent predictors of cardiovascular mortality. Conclusions TIMI and GRACE score but not DSE and MPS are accurate predictors of long-term cardiovascular mortality, even in chest pain patients with a normal or non-diagnostic electrocardiogram undergoing a rule-out protoco

Awareness and periconceptional use of folic acid among non-western and western women in the Netherlands following the 1995 publicity campaign

OBJECTIVE: To investigate the influence of ethnicity on the awareness and use of folic acid by pregnant women.DESIGN: Secondary data analysis.METHOD: Using the data on 1555 women, collected during a cross-sectional study conducted among pregnant women with good knowledge of the Dutch language in 1996, the authors determined what was known about the recommendation to use folic acid around the time of conception and what the actual use was. Women were defined as either 'western' or 'non-western' on the basis of the place of birth of the woman and her parents.RESULTS: Of the 1555 pregnant women, 74 (5%) were non-western or of non-western descent. Non-western women more often had a lower educational level than western women (51% versus 34%; p = 0.002) and more often had an unintended pregnancy (24% versus 8%; p &lt; 0.0001). 41% of the non-western women had heard of the recommendation to use folic acid before pregnancy, compared to 79% of the western women (p &lt; 0.0001). However, the use of folic acid was not significantly different between non-western and western women (56% versus 69%) if they had been aware of the recommendation to use folic acid before pregnancy. Awareness of the recommendation to use folic acid was higher in older women (OR: 1.46; 95% CI: 1.13-1.89), women of western descent (0.27; 0.16-0.47), women with a higher level of education (0.35; 0.27-0.45) and in case of planned pregnancy (0.45; 0.31-0.67). The use of folic acid, restricted to women who were aware of the recommendation to use folic acid before their pregnancy, was higher in older women (1.37; 1.05-1.80) and lower in those with more previous pregnancies (0.57; 0.43-0.75) and in case of an unplanned pregnancy (0.55; 0.34-0.88).CONCLUSION: Although non-western women had less knowledge of the recommendation to use folic acid than western women, the use of folic acid was not significantly different from that by western women if they had been aware of the recommendation to use folic acid before pregnancy. Continued education on folic acid targeting non-western and western women is important.</p