Does access to cardiac investigation and treatment contribute to social and ethnic differences in coronary heart disease? Whitehall II prospective cohort study

Objective: To determine whether access to cardiac procedures and drugs contributes to social and ethnic differences in coronary heart disease in a population setting. Design: Prospective study with follow up over 15 years. Civil service employment grade was used as a measure of individual socioeconomic position. Need for cardiac care was determined by the presence of angina, myocardial infarction, and coronary risk factors. Setting: 20 civil service departments originally located in London. Participants: 10 308 civil servants (3414 women; 560 South Asian) aged 35-55 years at baseline in 1985-8. Main outcome measures: Use of exercise electrocardiography, coronary angiography, and coronary revascularisation procedures and secondary prevention drugs. Results: Inverse social gradients existed in incident coronary morbidity and mortality. South Asian participants also had higher rates than white participants. After adjustment for clinical need, social position showed no association with the use of cardiac procedures or secondary prevention drugs. For example, men in the low versus high employment grade had an age adjusted odds ratio for angiography of 1.87 (95% confidence interval 1.32 to 2.64), which decreased to 1.27 (0.83 to 1.94) on adjustment for clinical need. South Asians tended to be more likely to have cardiac procedures and to be taking more secondary prevention drugs than white participants, even after adjustment for clinical need. Conclusion: This population based study, which shows the widely observed social and ethnic patterning of coronary heart disease, found no evidence that low social position or South Asian ethnicity was associated with lower use of cardiac procedures or drugs, independently of clinical need. Differences in medical care are unlikely to contribute to social or ethnic differences in coronary heart disease in this cohort

An overview of shed ice impact in the NASA Lewis Icing Research Tunnel

One of the areas of active research in commercial and military rotorcraft is directed toward developing the capability of sustained flight in icing conditions. The emphasis to date has been on the accretion and subsequent shedding of ice in an icing environment, where the shedding may be natural or induced. Historically, shed-ice particles have been a problem for aircraft, particularly rotorcraft. Because of the high particle velocities involved, damage to a fuselage or other airframe component from a shed-ice impact can be significant. Design rules for damage tolerance from shed-ice impact are not well developed because of a lack of experimental data. Thus, NASA Lewis (LeRC) has begun an effort to develop a database of impact force and energy resulting from shed ice. This effort consisted of a test of NASA LeRC's Model Rotor Test Rig (MRTR) in the Icing Research Tunnel (IRT). Both natural shedding and forced shedding were investigated. Forced shedding was achieved by fitting the rotor blades with Small Tube Pneumatic (STP) deicer boots manufactured by BF Goodrich. A detailed description of the test is given as well as the design of a new impact sensor which measures the force-time history of an impacting ice fragment. A brief discussion of the procedure to infer impact energy from a force-time trace are required for the impact-energy calculations. Recommendations and future plans for this research area are also provided

Understanding/unravelling carotenoid excited singlet states.

Carotenoids are essential light-harvesting pigments in natural photosynthesis. They absorb in the blue–green region of the solar spectrum and transfer the absorbed energy to (bacterio-)chlorophylls, and thus expand the wavelength range of light that is able to drive photosynthesis. This process is an example of singlet–singlet excitation energy transfer, and carotenoids serve to enhance the overall efficiency of photosynthetic light reactions. The photochemistry and photophysics of carotenoids have often been interpreted by referring to those of simple polyene molecules that do not possess any functional groups. However, this may not always be wise because carotenoids usually have a number of functional groups that induce the variety of photochemical behaviours in them. These differences can also make the interpretation of the singlet excited states of carotenoids very complicated. In this article, we review the properties of the singlet excited states of carotenoids with the aim of producing as coherent a picture as possible of what is currently known and what needs to be learned

A weighted configuration model and inhomogeneous epidemics

A random graph model with prescribed degree distribution and degree dependent edge weights is introduced. Each vertex is independently equipped with a random number of half-edges and each half-edge is assigned an integer valued weight according to a distribution that is allowed to depend on the degree of its vertex. Half-edges with the same weight are then paired randomly to create edges. An expression for the threshold for the appearance of a giant component in the resulting graph is derived using results on multi-type branching processes. The same technique also gives an expression for the basic reproduction number for an epidemic on the graph where the probability that a certain edge is used for transmission is a function of the edge weight. It is demonstrated that, if vertices with large degree tend to have large (small) weights on their edges and if the transmission probability increases with the edge weight, then it is easier (harder) for the epidemic to take off compared to a randomized epidemic with the same degree and weight distribution. A recipe for calculating the probability of a large outbreak in the epidemic and the size of such an outbreak is also given. Finally, the model is fitted to three empirical weighted networks of importance for the spread of contagious diseases and it is shown that $R_0$ can be substantially over- or underestimated if the correlation between degree and weight is not taken into account

Results of a sub-scale model rotor icing test

A heavily instrumented sub-scale model of a helicopter main rotor was tested in the NASA Lewis Research Center Icing Research Tunnel (IRT) in September and November 1989. The four-bladed main rotor had a diameter of 1.83 m (6.00 ft) and the 0.124 m (4.9 in) chord rotor blades were specially fabricated for this experiment. The instrumented rotor was mounted on a Sikorsky Aircraft Powered Force Model, which enclosed a rotor balance and other measurement systems. The model rotor was exposed to a range of icing conditions that included variations in temperature, liquid water content, and median droplet diameter, and was operated over ranges of advance ratio, shaft angle, tip Mach number (rotor speed) and weight coefficient to determine the effect of these parameters on ice accretion. In addition to strain gage and balance data, the test was documented with still, video, and high speed photography, ice profile tracings, and ice molds. The sensitivity of the model rotor to the test parameters, is given, and the result to theoretical predictions are compared. Test data quality was excellent, and ice accretion prediction methods and rotor performance prediction methods (using published icing lift and drag relationships) reproduced the performance trends observed in the test. Adjustments to the correlation coefficients to improve the level of correlation are suggested

Model rotor icing tests in the NASA Lewis icing research tunnel

Tests of a lightly instrumented two-bladed teetering rotor and a heavily instrumented sub-scale articulated main rotor were conducted in the NASA Lewis Research Center Icing Research Tunnel (IRT) in August 1988 and September and November 1989. The first was an OH-58 tail rotor which had a diameter of 1.575 m and a blade chord of 0.133 m, and was mounted on a NASA designed test rig. The second, a four bladed articulated rotor, had a diameter of 1.83 m with 0.124 m chord blades specially fabricated for the experiment. This rotor was mounted on a Sikorsky Aircraft Powered Force Model, which enclosed a rotor balance and other measurement systems. The models were exposed to variations in temperature, liquid water content, and medium droplet diameter, and were operated over ranges of advance ratio, shaft angle, tip Mach number (rotor speed), and weight coefficient to determine the effect of these parameters on ice accretion. In addition to strain gage and balance data, the test was documented with still, video, and high speed photography, ice profile tracing, and ice molds. Presented here are the sensitivity of the model rotors to the test parameters and a comparison of the results to theoretical predictions

The Relationship Between Alternative Career and Technical Education (CTE) Teacher Licensure Requirements and CTE Teacher Shortage

Career and technical education (CTE) continues to face an annual shortage of qualified teachers in the profession. This shortage has caused an increase in the use of alternative certification/licensure pathways across the United States. These alternative pathways are highly divergent from state to state. Limited research has investigated CTE teacher shortage and the alternative certification/licensure requirements that contribute. Using archival data, this correlational study looked to determine if CTE alternative certification/licensure requirements can predict CTE teacher shortages. Logistic regression analysis was used to review all 50 states and the District of Columbia and determine if any of the criterion variables predicted CTE teacher shortage. After analysis, it was determined that none of the criterion variables of academic degree, work experience, mandatory testing, and program length was statistically significant in predicting CTE teacher shortage

Does autonomic function link social position to coronary risk? The Whitehall II study.

BACKGROUND: Laboratory and clinical studies suggest that the autonomic nervous system responds to chronic behavioral and psychosocial stressors with adverse metabolic consequences and that this may explain the relation between low social position and high coronary risk. We sought to test this hypothesis in a healthy occupational cohort. METHODS AND RESULTS: This study comprised 2197 male civil servants 45 to 68 years of age in the Whitehall II study who were undergoing standardized assessments of social position (employment grade) and the psychosocial, behavioral, and metabolic risk factors for coronary disease previously found to be associated with low social position. Five-minute recordings of heart rate variability (HRV) were used to assess cardiac parasympathetic function (SD of N-N intervals and high-frequency power [0.15 to 0.40 Hz]) and the influence of sympathetic and parasympathetic function (low-frequency power [0.04 to 0.15 Hz]). Low employment grade was associated with low HRV (age-adjusted trend for each modality, P< or =0.02). Adverse behavioral factors (smoking, exercise, alcohol, and diet) and psychosocial factors (job control) showed age-adjusted associations with low HRV (P<0.03). The age-adjusted mean low-frequency power was 319 ms2 among those participants in the bottom tertile of job control compared with 379 ms2 in the other participants (P=0.004). HRV showed strong (P<0.001) linear associations with components of the metabolic syndrome (waist circumference, systolic blood pressure, HDL cholesterol, triglycerides, and fasting and 2-hour postload glucose). The social gradient in prevalence of metabolic syndrome was explained statistically by adjustment for low-frequency power, behavioral factors, and job control. CONCLUSIONS: Chronically impaired autonomic function may link social position to different components of coronary risk in the general population

Validating Semi-Analytic Models of High-Redshift Galaxy Formation using Radiation Hydrodynamical Simulations

We use a cosmological hydrodynamic simulation calculated with Enzo and the semi-analytic galaxy formation model (SAM) GAMMA to address the chemical evolution of dwarf galaxies in the early universe. The long-term goal of the project is to better understand the origin of metal-poor stars and the formation of dwarf galaxies and the Milky Way halo by cross-validating these theoretical approaches. We combine GAMMA with the merger tree of the most massive galaxy found in the hydrodynamic simulation and compare the star formation rate, the metallicity distribution function (MDF), and the age-metallicity relationship predicted by the two approaches. We found that the SAM can reproduce the global trends of the hydrodynamic simulation. However, there are degeneracies between the model parameters and more constraints (e.g., star formation efficiency, gas flows) need to be extracted from the simulation to isolate the correct semi-analytic solution. Stochastic processes such as bursty star formation histories and star formation triggered by supernova explosions cannot be reproduced by the current version of GAMMA. Non-uniform mixing in the galaxy's interstellar medium, coming primarily from self-enrichment by local supernovae, causes a broadening in the MDF that can be emulated in the SAM by convolving its predicted MDF with a Gaussian function having a standard deviation of ~0.2 dex. We found that the most massive galaxy in the simulation retains nearby 100% of its baryonic mass within its virial radius, which is in agreement with what is needed in GAMMA to reproduce the global trends of the simulation.Comment: 26 pages, 13 figures, 2 tables, submitted to ApJ (version 2