2,299 research outputs found
Bridging the Semantic Gap with SQL Query Logs in Natural Language Interfaces to Databases
A critical challenge in constructing a natural language interface to database
(NLIDB) is bridging the semantic gap between a natural language query (NLQ) and
the underlying data. Two specific ways this challenge exhibits itself is
through keyword mapping and join path inference. Keyword mapping is the task of
mapping individual keywords in the original NLQ to database elements (such as
relations, attributes or values). It is challenging due to the ambiguity in
mapping the user's mental model and diction to the schema definition and
contents of the underlying database. Join path inference is the process of
selecting the relations and join conditions in the FROM clause of the final SQL
query, and is difficult because NLIDB users lack the knowledge of the database
schema or SQL and therefore cannot explicitly specify the intermediate tables
and joins needed to construct a final SQL query. In this paper, we propose
leveraging information from the SQL query log of a database to enhance the
performance of existing NLIDBs with respect to these challenges. We present a
system Templar that can be used to augment existing NLIDBs. Our extensive
experimental evaluation demonstrates the effectiveness of our approach, leading
up to 138% improvement in top-1 accuracy in existing NLIDBs by leveraging SQL
query log information.Comment: Accepted to IEEE International Conference on Data Engineering (ICDE)
201
On laminar groups, Tits alternatives and convergence group actions on 2
Following previous work of the second author, we establish more properties of groups of circle homeomorphisms which admit invariant laminations. In this paper, we focus on a certain type of such groups, so-called pseudo-fibered groups, and show that many 3-manifold groups are examples of pseudo-fibered groups. We then prove that torsion-free pseudo-fibered groups satisfy a Tits alternative. We conclude by proving that a purely hyperbolic pseudo-fibered group acts on the 2-sphere as a convergence group. This leads to an interesting question if there are examples of pseudo-fibered groups other than 3-manifold groups
Host cell protein control via CHO genome engineering
Chinese hamster ovary (CHO) cells, a major mammalian platform in biomanufacturing, produce and secret recombinant proteins along with host cell proteins (HCPs). Because residual HCPs in the final drug product can adversely affect (1) patients by causing immune responses, (2) drug efficacy, and (3) product stability, the effective removal of HCPs is necessary. Unfortunately, many studies have reported that many HCPs can be difficult to remove through downstream purification processes because they share similar biophysical properties to biopharmaceuticals. In this study we employed a genome engineering approach using clustered regularly interspaced short palindromic repeats and associated protein 9 (CRISPR/Cas9) system-mediated knockout to address difficult-to-remove HCP problems. Three HCPs (Cathepsin D, Nidogen-1, and Prosaposin) that are known to be difficult to remove were selected, and respective knockout clones were isolated without using selective reagents or reporter genes. Clones for each HCP were characterized using various analysis methods. Taken together, we demonstrate the applicability of the CRISPR/Cas9 system to eliminate difficult-to-remove HCP expression in an industry-relevant setting
Is a typical bi-Perron number a pseudo-Anosov dilatation?
In this note, we deduce a partial answer to the question in the title. In particular, we show that asymptotically almost all bi-Perron algebraic unit whose characteristic polynomial has degree at most do not correspond to dilatations of pseudo-Anosov maps on a closed orientable surface of genus for . As an application of the argument, we also obtain a statement on the number of closed geodesics of the same length in the moduli space of area one abelian differentials for low genus cases
On ASEP with Step Bernoulli Initial Condition
This paper extends results of earlier work on ASEP to the case of step
Bernoulli initial condition. The main results are a representation in terms of
a Fredholm determinant for the probability distribution of a fixed particle,
and asymptotic results which in particular establish KPZ universality for this
probability in one regime. (And, as a corollary, for the current fluctuations.)Comment: 16 pages. Revised version adds references and expands the
introductio
Exponential torsion growth for random 3-manifolds
We show that a random 3-manifold with positive first Betti number admits a tower of cyclic covers with exponential torsion growth
Random walks and random fixed-point free involutions
A bijection is given between fixed point free involutions of
with maximum decreasing subsequence size and two classes of vicious
(non-intersecting) random walker configurations confined to the half line
lattice points . In one class of walker configurations the maximum
displacement of the right most walker is . Because the scaled distribution
of the maximum decreasing subsequence size is known to be in the soft edge GOE
(random real symmetric matrices) universality class, the same holds true for
the scaled distribution of the maximum displacement of the right most walker.Comment: 10 page
Dynamics of a tagged particle in the asymmetric exclusion process with the step initial condition
The one-dimensional totally asymmetric simple exclusion process (TASEP) is
considered. We study the time evolution property of a tagged particle in TASEP
with the step-type initial condition. Calculated is the multi-time joint
distribution function of its position. Using the relation of the dynamics of
TASEP to the Schur process, we show that the function is represented as the
Fredholm determinant. We also study the scaling limit. The universality of the
largest eigenvalue in the random matrix theory is realized in the limit. When
the hopping rates of all particles are the same, it is found that the joint
distribution function converges to that of the Airy process after the time at
which the particle begins to move. On the other hand, when there are several
particles with small hopping rate in front of a tagged particle, the limiting
process changes at a certain time from the Airy process to the process of the
largest eigenvalue in the Hermitian multi-matrix model with external sources.Comment: 48 pages, 8 figure
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