Présentation et discussion de quelques diagrammes de phases dans le système Ca-Fe-Si-C-O des formations ferrifères de la région de Berrahal - Oued El Aneb (massif de l’Edough, NE algérien)

La région de Berrahal-Oued El Aneb (Edough) contient d'anciens gisements et indices de magnétite ± hématite liés à des roches calco-silicatées. Les corps minéralisés sont stratiformes, plus ou moins lenticulaires, et sont encaissés dans des schistes à disthène, staurotide et grenat au voisinage de marbres. Les principales paragenèses relevées dans les corps  minéralisés comprennent essentiellement magnétite, olivine (fayalite), pyroxène (hédenbergite), calcite, micas et grenat (almandin). Ces minéraux ont subi les mêmes effets du métamorphisme que les roches encaissantes. L’interprétation d’analyses chimiques montre que les formations à l'origine des corps minéralisés correspondent à des roches carbonatoferrifères impures, plus ou moins siliceuses. Le fer aurait été exprimé sous forme carbonatée (sidérite). Un processus pétrogénétique, illustré par la discussion de diagrammes de phases, expliquant l'évolution des corps minéralisés dans leur contexte est proposé et nous a conduit à retracer la succession des différentes étapes d'évolution de ces corps et à expliquer la cristallisation des minéraux constituant les paragenèsesentrant dans la composition des faciès de minerai par une décarbonatation (+ oxydoréduction) métamorphique des formations originelles.Mots-clés : Edough, magnétite, formations ferrifères, métamorphisme, décarbonatation

Алгоритм определения оптимального числа волокон используемых при внутритканевой фотодинамической терапии рака молочной железы на основании диффузионного уравнения

It is essential in interstitial Photodynamic therapy (iPDT) treatment planning to ensure a homogeneous distribution within a tumor volume using cylindrical diffusing fibers while keeping the surrounding tissue intact. Light distribution is simulated through two algorithms based on the diffusion equation assuming diffusers as light sources. The first algorithm analyzes the diffusion equation and studies the effects of different variables (optical properties, delivered power, diffuser length, and position). Next, optical properties of breast were applied to estimate the volume that receives accepted light dose from one diffuser. In the second algorithm, multiple diffusers were simulated in order to find the relation between the volume and the number of required diffusers which are needed to cover cubical or cylindrical volume with sufficient light dose. Throughout this study, real values of optical properties, clinical laser power, and treatment time were considered to evaluate sufficient light doses. This study is in agreement with previous works in that optical properties are the major factors influencing light distribution in iPDT. It is shown that for a homogeneous phantom mimicking breast cancer and cubical or cylindrical shape, the number of required fibers N equal W×L or D2 respectively.При планировании внутритканевой фотодинамической терапии (iPDT ) с использованием цилиндрических диффузных волокон важно обеспечить однородное распределение света по всему объему опухоли, сохранив при этом целостность окружающей ткани. Авторы данной статьи смоделировали распределение света с помощью двух алгоритмов, основанных на уравнении диффузии, в которых в качестве источников света используются цилиндрические диффузоры. Первый алгоритм анализирует уравнение диффузии и изучает влияние различных переменных (оптических свойств источника, применяемой мощности, длины диффузора и его положения). Затем были использованы параметры оптических свойств молочной железы для оценки объема, который рассчитывает световую дозу от одного диффузора. Во втором алгоритме было смоделировано несколько рассеивателей для нахожде ния соотношения между объемом и количеством рассеивателей, необходимых для покрытия кубического или цилиндрического объема достаточной световой дозой. На протяжении всего этого исследования рассматривались реальные значения оптических свойств, клинической мощности лазера и времени лечения для оценки достаточных световых доз. Это исследование согласуется с предыдущими работами в том, что оптические свойства являются основными факторами, влияющими на распределение света при iPDT. Показано, что, для однородного фантома, имитирующего рак молочной железы, кубической или цилиндрической формы, количество требуемых волокон N равно W×L или D2 , соответственно

A RIAM/lamellipodin-talin-integrin complex forms the tip of sticky fingers that guide cell migration.

The leading edge of migrating cells contains rapidly translocating activated integrins associated with growing actin filaments that form 'sticky fingers' to sense extracellular matrix and guide cell migration. Here we utilized indirect bimolecular fluorescence complementation to visualize a molecular complex containing a Mig-10/RIAM/lamellipodin (MRL) protein (Rap1-GTP-interacting adaptor molecule (RIAM) or lamellipodin), talin and activated integrins in living cells. This complex localizes at the tips of growing actin filaments in lamellipodial and filopodial protrusions, thus corresponding to the tips of the 'sticky fingers.' Formation of the complex requires talin to form a bridge between the MRL protein and the integrins. Moreover, disruption of the MRL protein-integrin-talin (MIT) complex markedly impairs cell protrusion. These data reveal the molecular basis of the formation of 'sticky fingers' at the leading edge of migrating cells and show that an MIT complex drives these protrusions

Les métastases ovariennes d’origine biliaire: 2 cas avec revue de la littérature

Les ovaires constituent un site fréquent de métastases. L'origine gastrique prédomine. Les métastases ovariennes d'origine biliaire sont rarement rapportées dans la littérature. Les auteurs rapportent deux cas de   métastases ovariennes d'origine vésiculaire chez des patientes âgées respectivement de 63 et 40 ans. Le diagnostic de ces métastases ovariennes était concomitant avec le cancer d'origine dans le premier cas, et a survenu à distance de l'atteinte initiale dans le deuxième cas. Le diagnostic est suggéré sur les données radiologiques et confirmé histologiquement. Les métastases ovariennes d'origine biliaire sont rarement rapportées dans la littérature. L'atteinte ovarienne pose un problème de diagnostic différentiel avec une atteinte ovarienne primitive surtout si l'atteinte ovarienne précède les manifestations biliaires. L'imagerie joue un rôle important et oriente sur le caractère secondaire de l'atteinte ovarienne

Electromagnetic corrections in the anomaly sector

Chiral perturbation theory in the anomaly sector for $N_f=2$ is extended to include dynamical photons, thereby allowing a complete treatment of isospin breaking. A minimal set of independent chiral lagrangian terms is determined and the divergence structure is worked out. There are contributions from irreducible and also from reducible one-loop graphs, a feature of ChPT at order larger than four. The generating functional is non-anomalous at order $e^2p^4$, but not necessarily at higher order in $e^2$. Practical applications to $\gamma\pi\to\pi\pi$ and to the $\pi^0\to2\gamma$ amplitudes are considered. In the latter case, a complete discussion of the corrections beyond current algebra is presented including quark mass as well as electromagnetic effects.Comment: 26 pages, 3 figure

Indolent Small Intestinal CD4+ T-cell Lymphoma Is a Distinct Entity with Unique Biologic and Clinical Features

Enteropathy-associated T-cell lymphomas (EATL) are rare and generally aggressive types of peripheral T-cell lymphomas. Rare cases of primary, small intestinal CD4+ T-cell lymphomas with indolent behavior have been described, but are not well characterized. We describe morphologic, phenotypic, genomic and clinical features of 3 cases of indolent primary small intestinal CD4+ T-cell lymphomas. All patients presented with diarrhea and weight loss and were diagnosed with celiac disease refractory to a gluten free diet at referring institutions. Small intestinal biopsies showed crypt hyperplasia, villous atrophy and a dense lamina propria infiltrate of small-sized CD4+ T-cells often with CD7 downregulation or loss. Gastric and colonic involvement was also detected (n = 2 each). Persistent, clonal TCRβ gene rearrangement products were detected at multiple sites. SNP array analysis showed relative genomic stability, early in disease course, and non-recurrent genetic abnormalities, but complex changes were seen at disease transformation (n = 1). Two patients are alive with persistent disease (4.6 and 2.5 years post-diagnosis), despite immunomodulatory therapy; one died due to bowel perforation related to large cell transformation 11 years post-diagnosis. Unique pathobiologic features warrant designation of indolent small intestinal CD4+ T-cell lymphoma as a distinct entity, greater awareness of which would avoid misdiagnosis as EATL or an inflammatory disorder, especially celiac disease

The accuracy of currently used WHO´s Body Mass Index cut-off points to measure Overweight and Obesity in Syrian women: A correlation study

Purpose: Obesity is a common health problem in both developed and developing countries. BMI is commonly used to identify obesity. However, there is increasing evidence that the relationship between BMI and BF% differs among various ethnicities. The main objectives of this study are (1) to evaluate the correlation between BF% as determined by BIA, DEXA, Deuterium oxide (D2O) and BMI, (2) to assess the accuracy of currently used WHOÅLs BMI cut-off points to identify overweight and obesity among Syrian women. Material and Methods: A total of 908 healthy Syrian women aged 18-60 years participated in this study. Weight, height, BMI, BF% assessed by BIA and DEXA, and D2O have been determined. Results: BF% results obtained by BIA and DEXA, and D2O revealed strong correlations. BMI showed a statistically significant correlation with BF% determined by BIA, DEXA and D2O. Obesity when defined as BMI ≥ 30 and as BF% > 35% (derived from BIA, DEXA and D2O) classified 43%, 52.5%, 75.9% and 72.7% of women as obese, respectively. ROC analysis defined BMI cut-off points for overweight and obesity of 22.5 and 25.7, respectively. Using the new BMI cut-off point, the prevalence of obesity among Syrian women was increased by 24%. Conclusions: The current BMI cut-off points recommended by WHO underestimate the prevalence of overweight and obesity among Syrian women. Our data suggests that it is important to lower the proposed WHOÅLs BMI cut-off points for the Syrian women

Digital Predistortion of Wideband Signals with Reduced Complexity Based on Feedback Wiener System, Journal of Telecommunications and Information Technology, 2021, nr 2

Digital predistortion (DPD) using baseband signals is commonly used for power amplifier linearization. This paper is devoted to this subject and aims to reduce DPD complexity. In this study, we propose a structure that allows to decrease the number of DPD parameters by using multiple blocks, with each one of them dedicated to characterizing the non-linear behavior and/or memory effects. Such a structure is based on the feedback Wiener system, involving a FIR filter used as a feedback path to reproduce the PA inverse dynamics. A memory polynomial block (MP) is inserted as the final element to minimize the modeling errors. A relevant model identification method, based on an iterative algorithm, has been developed as well. The proposed architecture is used for the linearization of a commercial class-AB LDMOS RF PA by NXP Semiconductors, in wideband communication systems. Comparison of performance with the conventional generalized memory polynomial model (GMP) shows that the proposed model offers similar results, with its advantage consisting in the reduced number of parameters