453 research outputs found
First glycopeptide-resistant Enterococcus faecium isolate from blood culture in Ankara, Turkey.
1,2-Bis[(1,3-benzodioxol-5-yl)methylidene]hydrazine
The complete molecule of the title compound, C16H12N2O4, is generated by the application of a centre of inversion. The (1,3-benzodioxol-5-yl)methylidene fused-ring system is approximately planar (r.m.s. deviation = 0.020 Å) and is essentially coplanar with the central hydrazine group [dihedral angle = 5.08 (9)°]. Weak π–π intermolecular interactions are observed [centroid–centroid distance = 3.8553 (8) Å], providing some packing stability
1,2-Bis(3-phenoxybenzylidene)hydrazine
Molecules of the title compound, C26H20N2O2, reside on crystallographic centres of inversion located at the mid-point of the N—N bond. The benzylidene ring is essentially coplanar with the central hydrazine group, with an interplanar angle of 4.5 (2)°, whereas the phenyl ring is oriented at 34.0 (3)° with respect to the mean plane of the central 1,2-dibenzylidenehydrazine group. In the crystal, C—H⋯π(arene)-ring interactions link molecules about inversion centres
Lower abdominal gossypiboma mimics ovarian teratoma: a case report and review of the literature
Distributed Medical Image Analysis and Diagnosis through Crowd-Sourced Games: A Malaria Case Study
In this work we investigate whether the innate visual recognition and learning capabilities of untrained humans can be used in conducting reliable microscopic analysis of biomedical samples toward diagnosis. For this purpose, we designed entertaining digital games that are interfaced with artificial learning and processing back-ends to demonstrate that in the case of binary medical diagnostics decisions (e.g., infected vs. uninfected), with the use of crowd-sourced games it is possible to approach the accuracy of medical experts in making such diagnoses. Specifically, using non-expert gamers we report diagnosis of malaria infected red blood cells with an accuracy that is within 1.25% of the diagnostics decisions made by a trained medical professional
Reactive Molecular Dynamics study on the first steps of DNA-damage by free hydroxyl radicals
We employ a large scale molecular simulation based on bond-order ReaxFF to
simulate the chemical reaction and study the damage to a large fragment of
DNA-molecule in the solution by ionizing radiation. We illustrate that the
randomly distributed clusters of diatomic OH-radicals that are primary products
of megavoltage ionizing radiation in water-based systems are the main source of
hydrogen-abstraction as well as formation of carbonyl- and hydroxyl-groups in
the sugar-moiety that create holes in the sugar-rings. These holes grow up
slowly between DNA-bases and DNA-backbone and the damage collectively propagate
to DNA single and double strand break.Comment: 6 pages and 8 figures. movies and simulations are available at:
http://qmsimulator.wordpress.com
Temporal bone verrucous carcinoma: outcomes and treatment controversy
Verrucous carcinoma is a rare tumor that presents in the head and neck with the most common sites being the oral cavity and larynx. Fourteen cases of verrucous carcinoma of the temporal bone have been described in literature; this study aims to examine treatment outcomes and discuss the controversy surrounding postoperative radiation. The study design included a literature review along with individual case report in the setting of a tertiary care medical center. Outcome analysis of all cases of verrucous carcinoma of the temporal bone, which are documented in the English literature, and presentation of a single patient report including gross, histologic and radiologic analyses were performed. The longest recorded survival for verrucous carcinoma of the temporal bone occurs in patients treated with surgery alone. Poorer outcomes for patients treated with adjuvant (chemo)radiation may be due to more advanced stage of disease at the time of treatment. Early reports of radiation leading to tumor dedifferentiation or early recurrence are not supported by more recent studies. Whether adjuvant radiation therapy is indicated in verrucous carcinoma of the temporal bone remains controversial
Primary hyperparathyroidism as first manifestation in multiple endocrine neoplasia type 2A: an international multicenter study.
Multiple endocrine neoplasia type 2A (MEN 2A) is a rare syndrome caused by RET germline mutations and has been associated with primary hyperparathyroidism (PHPT) in up to 30% of cases. Recommendations on RET screening in patients with apparently sporadic PHPT are unclear. We aimed to estimate the prevalence of cases presenting with PHPT as first manifestation among MEN 2A index cases and to characterize the former cases.
An international retrospective multicenter study of 1085 MEN 2A index cases. Experts from MEN 2 centers all over the world were invited to participate. A total of 19 centers in 17 different countries provided registry data of index cases followed from 1974 to 2017.
Ten cases presented with PHPT as their first manifestation of MEN 2A, yielding a prevalence of 0.9% (95% CI: 0.4-1.6). 9/10 cases were diagnosed with medullary thyroid carcinoma (MTC) in relation to parathyroid surgery and 1/10 was diagnosed 15 years after parathyroid surgery. 7/9 cases with full TNM data were node-positive at MTC diagnosis.
Our data suggest that the prevalence of MEN 2A index cases that present with PHPT as their first manifestation is very low. The majority of index cases presenting with PHPT as first manifestation have synchronous MTC and are often node-positive. Thus, our observations suggest that not performing RET mutation analysis in patients with apparently sporadic PHPT would result in an extremely low false-negative rate, if no other MEN 2A component, specifically MTC, are found during work-up or resection of PHPT.S D received a national grant (AZV 16-32665A).S
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