Examining master's student satisfaction of interactive and supervisory styles of supervisors

Preparing the thesis is one of the most important parts of education in higher education level.The current study aimed to determine the level of master student satisfaction of interactive and supervisory styles of supervisors. This research was descriptive survey. The population of the study was all entering male and female doctoral students in 2013-14 academic-year majoring in humanities, science and engineering in Tehran's public universities who defended their master's thesis in the past two years (N=3092). Using Cochran sampling formula, 342 individuals were selected as research sample. A researcher made questionnaire was used for data collection. The validity of the questionnaire was determined by experts and its reliability was measured by Cronbach's alpha (α=.87.2), showing an acceptable level of research tool. One sample t test was used for data analysis. Based on the obtained results, the students were not satisfied with any of the supervisory styles of supervisors. In connection to the interactive styles, students adopted horizontal interactive style as the most interactive style. In supervisory styles, using a combination of styles; and in interactive styles, using a positive and dynamic horizontal style is suggested to the supervisors

Stochastic system of systems architecture for adaptive expansion of smart distribution grids

The incorporation of the reconfiguration into the expansion planning of smart distribution networks is addressed in this paper, in which the potential of distributed energy resources and demand response (DR) are modeled. The system of systems (SoS) architecture is employed to model the strategy of a distribution company (DISCO), a private investor (PI), and a DR provider (DRP). The SoS is an efficient modeling architecture to model the behavior of independent and autonomous systems with distinct objective functions who are able to share some data and work together. The aim of the DISCO is to upgrade the system with the optimal cost and reliability, whereas the PI and DRP want to maximize their profit. The DISCO should try to persuade the PI to install DGs (Distributed generations) by offering the guaranteed purchasing prices. Furthermore, the DRP is a market player who can negotiate with the DISCO to sign a contract to sell the purchased DR capacities from the customers. The uncertainties of the DISCO problem is handled by using the chance-constraint method, but the PI and DRP use the conditional value at risk method to model their uncertainties. Finally, to solve the proposed model, the multiobjective optimization algorithm is employed

Corticosteroids or platelet-rich plasma injections for rotator cuff tendinopathy: a randomized clinical trial study

Background: Studies evaluating the role of both corticosteroids and platelet-rich plasma (PRP) in the treatment of rotator cuff (RC) tendinopathies have been contradicting. We compared structural and clinical changes in RC muscles after corticosteroids and PRP injections. Methods: This is a randomized double-blind clinical trial. All individuals with diagnosis of RC tendinitis during 2014�2017 were considered. Individuals were randomly allocated to either receive PRP or corticosteroids. Overall, 3cc of PRP was injected within the subacromial joint and another 3cc was injected at the site of the tendon tear, under the guide of sonography. For the corticosteroid group, 1cc of Depo-medrol 40mg and 1cc of lidocaine (2) was injected within the subacromial joint. Results: Overall, 58 patients entered the study. Comparison of pain, range of motion (ROM), Western Ontario RC (WORC), Disability of Arm-Hand-Shoulder (DASH) scores, and supraspinatus thickness showed significant improvement during follow-ups in both groups (p<0.05). During 3 months of follow-up, pain improvement was significantly better within the PRP group during (from 6.66±2.26 to 3.08±2.14 and 5.53±1.80 to 3.88±1.99, respectively; p=0.023). Regarding ROM, the PRP group had significant improvement in adduction (20.50°±8.23° to 28°±3.61° and 23.21°±7.09° to 28.46°±4.18° for the PRP and corticosteroid groups, respectively; p=0.011) and external rotation (59.66°±23.81° to 76.66°±18.30° and 57.14°±24.69° to 65.57°±26.39°, for the PRP and corticosteroid groups, respectively; p=0.036) compared to the corticosteroid group. Conclusion: We found that PRP renders similar results to that of corticosteroids in most clinical aspects among patients with RC tendinopathies; however, pain and ROM may show more significant improvement with the use of PRP. Considering that the use of corticosteroids may be contraindicated in some patients and may be associated with the risk of tendon rupture, we suggest the use of PRP in place of corticosteroid-based injections among patients with RC tendinopathy. Trial registration: Clinical trial registration code: IRCT201302174251N9 © 2021, The Author(s)

Allograft or autograft in skeletally immature anterior cruciate ligament reconstruction: A prospective evaluation using both partial and complete transphyseal techniques

Objective: We compared autografts and allograft using partial and complete transphyseal anterior cruciate ligament (ACL) reconstruction techniques among skeletally immature individuals. Methods: Male and females younger than 18 and 16 years old, respectively, diagnosed with ACL tear from April 2006 to March 2012 entered the study. One group had four-strand hamstring autograft, and the other had tibialis posterior allograft reconstruction. Those who had allografts either had hyper-laxity or recurvatum. Results: Achieved mean (± SD) 2000 International Knee Documentation Committee subjective score was not statistically different (P = 0.385) between allograft (n = 13) (84.3 ± 3.2) and autograft groups (n = 18) (85.6 ± 4.4). Mean Knee injury and Osteoarthritis Outcome Score (KOOS) subscale Knee-Related Quality of Life at 2 years was 78.0 ± 7.2 and 75 ± 7.4 for allograft and autograft groups, respectively (p = 0.261). Mean 2-year KOOS subscale Sports and Recreation was 82.1 ± 5.8 and 84.8 ± 6.6 for allograft and autograft groups, respectively (p = 0.244). No patient reported instability, giving way, or locking of the knee. Pivot shift test was negative in all patients; however, a minor positive Lachman test was found in six cases (46) within the allograft group and seven cases (39) in the autograft group. One postoperative septic arthritis was documented in the autograft group. Conclusion: Considering existing concern that joint laxity and recurvatum are among the precursors of non-contact ACL injury in adolescents, bone-patellar-bone autografts are not applicable in this age group because of the open physis; furthermore, considering that hamstring autografts are insufficient (size thickness and stretchability), we recommend soft tissue allografts for ACL reconstruction in skeletally immature patients. © 2019 The Author(s)

Overview of electric energy distribution networks expansion planning

Planning of the electric distribution networks is complex and about upgrading the system to satisfy the demand and constraints with the best economic plan. The planning alternatives include the expansion of substations, installing new distributed generation (DG) facilities, upgrading distribution feeders, etc. In the modern networks, distribution planners must gain the confidence of the reversibility of the investment where renewable energy resources (RERs) inject clean and cost-effective electrical power to respond to the rising demand and satisfy environmental standards. This paper is an exhaustive review on the distribution network expansion planning (DEP) including the modelling of DEP (possible objective functions, problem constraints, different horizon time, and problem variables), optimization model (single/multi-objective), the expansion of distributed energy resources (DERs), problem uncertainties, etc. We discuss the requirements of integrated energy district master planning to avoid conflicts between the goal of independence of district planning on energy, e.g. heat and electricity, and that of dependencies on the local electric utilities regarding instant power balance and stability services. Finally, we describe the primary future R&D trends in the field of distribution network planning

GPR35 promotes glycolysis, proliferation, and oncogenic signaling by engaging with the sodium potassium pump.

The sodium potassium pump (Na/K-ATPase) ensures the electrochemical gradient of a cell through an energy-dependent process that consumes about one-third of regenerated ATP. We report that the G protein-coupled receptor GPR35 interacted with the α chain of Na/K-ATPase and promotes its ion transport and Src signaling activity in a ligand-independent manner. Deletion of Gpr35 increased baseline Ca2+ to maximal levels and reduced Src activation and overall metabolic activity in macrophages and intestinal epithelial cells (IECs). In contrast, a common T108M polymorphism in GPR35 was hypermorphic and had the opposite effects to Gpr35 deletion on Src activation and metabolic activity. The T108M polymorphism is associated with ulcerative colitis and primary sclerosing cholangitis, inflammatory diseases with a high cancer risk. GPR35 promoted homeostatic IEC turnover, whereas Gpr35 deletion or inhibition by a selective pepducin prevented inflammation-associated and spontaneous intestinal tumorigenesis in mice. Thus, GPR35 acts as a central signaling and metabolic pacesetter, which reveals an unexpected role of Na/K-ATPase in macrophage and IEC biology.European Research Council Consolidator Grant n° 648889 to A.K. Scientia Fellowship (FP7-PEOPLE-2013-COFUND) grant agreement n° 609020 to G.S. Addenbrooke’s Charitable Trust (ACT 25/16A) to J.E.E. UniNA and Compagnia Di San Paolo ‘STAR program for young researchers’ fellowship to E.P

COVID-19 among patients with orthopedic surgery: our experience from the Middle East

Background: We report our experiences with COVID-19 in one of the largest referral orthopedic centers in the Middle East and aimed to describe the epidemiology and clinical characteristics of these patients. Methods: During February 20 and April 20, 2020, patients who underwent orthopedic surgery and healthcare staff who were in contact with these patients were screened for COVID-19. To identify patients who were in the incubation period of COVID-19 during their hospital stay, all patients were tested again for COVID-19 4 weeks after discharge. Results: Overall, 1244 patients underwent orthopedic surgery (1123 emergency and 121 elective) during the study period. Overall, 17 patients were diagnosed with COVID-19 during hospital admission and seven after discharge. Among the total 24 patients with COVID-19, 15 were (62.5) males with a mean (SD) age of 47.0±1.6 years old. Emergency surgeries were performed in 20 (83.3) patients, and elective surgery was done in the remaining 4 patients which included one case of posterior spinal fusion, spondylolisthesis, acromioclavicular joint dislocation, and one case of leg necrosis. A considerable number of infections occurred in patients with intertrochanteric fractures (n=7, 29.2), followed by pelvic fractures (n=2, 8.3), humerus fractures (n=2, 8.3), and tibial plateau fractures (n=2, 8.3). Fever (n=11, 45.8) and cough (n=10, 37.5) were the most common symptoms among patients. Laboratory examinations showed leukopenia in 2 patients (8.3) and lymphopenia in 4 (16.7) patients. One patient with a history of cancer died 2 weeks after discharge due to myocardial infarction. Among hospital staff, 26 individuals contracted COVID-19 during the study period, which included 13 (50) males. Physicians were the most commonly infected group (n = 11), followed by operation room technicians (n = 5), nurses (n = 4), and paramedics (n = 4). Conclusions: Patients who undergo surgical treatment for orthopedic problems, particularly lower limb fractures with limited ambulation, are at a higher risk of acquiring COVID-19 infections, although they may not be at higher risks for death compared to the general population. Orthopedic surgeons in particular and other hospital staff who are in close contact with these patients must be adequately trained and given appropriate personal protective equipment during the COVID-19 outbreak. © 2021, The Author(s)

Correction to: "Comparative repair capacity of knee osteochondral defects using regenerated silk fiber scaffolds and fibrin glue with/without autologous chondrocyes during 36 weeks in rabbit model (Cell and Tissue Research, (2016), 364, 3, (559-572), 10.1007/s00441-015-2355-9)

In this paper, figure 1 and its associated text were erroneously identical to that of another article from our group (Mobini et al., 2016, Journal of Biomaterial Application, SAGE publications). Unfortunately, copyright permission to re-use figure 1 and its related data were not requested. The authors would like to apologize for any confusion caused in this regard. © 2019, Springer-Verlag GmbH Germany, part of Springer Nature

Long-Acting Cabotegravir and Rilpivirine after Oral Induction for HIV-1 Infection.

BACKGROUND: Long-acting injectable regimens may simplify therapy for patients with human immunodeficiency virus type 1 (HIV-1) infection. METHODS: We conducted a phase 3, randomized, open-label trial in which adults with HIV-1 infection who had not previously received antiretroviral therapy were given 20 weeks of daily oral induction therapy with dolutegravir-abacavir-lamivudine. Participants who had an HIV-1 RNA level of less than 50 copies per milliliter after 16 weeks were randomly assigned (1:1) to continue the current oral therapy or switch to oral cabotegravir plus rilpivirine for 1 month followed by monthly injections of long-acting cabotegravir plus rilpivirine. The primary end point was the percentage of participants who had an HIV-1 RNA level of 50 copies per milliliter or higher at week 48 (Food and Drug Administration snapshot algorithm). RESULTS: At week 48, an HIV-1 RNA level of 50 copies per milliliter or higher was found in 6 of 283 participants (2.1%) who received long-acting therapy and in 7 of 283 (2.5%) who received oral therapy (adjusted difference, -0.4 percentage points; 95% confidence interval [CI], -2.8 to 2.1), a result that met the criterion for noninferiority for the primary end point (margin, 6 percentage points). An HIV-1 RNA level of less than 50 copies per milliliter at week 48 was found in 93.6% who received long-acting therapy and in 93.3% who received oral therapy (adjusted difference, 0.4 percentage points; 95% CI, -3.7 to 4.5), a result that met the criterion for noninferiority for this end point (margin, -10 percentage points). Of the participants who received long-acting therapy, 86% reported injection-site reactions (median duration, 3 days; mild or moderate severity, 99% of cases); 4 participants withdrew from the trial for injection-related reasons. Grade 3 or higher adverse events and events that met liver-related stopping criteria occurred in 11% and 2%, respectively, who received long-acting therapy and in 4% and 1% who received oral therapy. Treatment satisfaction increased after participants switched to long-acting therapy; 91% preferred long-acting therapy at week 48. CONCLUSIONS: Therapy with long-acting cabotegravir plus rilpivirine was noninferior to oral therapy with dolutegravir-abacavir-lamivudine with regard to maintaining HIV-1 suppression. Injection-site reactions were common. (Funded by ViiV Healthcare and Janssen; FLAIR ClinicalTrials.gov number, NCT02938520.)