8 research outputs found
Palladium‐Catalyzed Combinatorial Synthesis of Biphenyls on Droplet Microarrays at Nanoliter Scale
The rising costs of pharmaceutical research are currently limiting the productivity of drug discovery and development, but can potentially be diminished via miniaturization of the synthesis and screening of new compounds. As droplet microarrays already present themselves as a versatile tool for highly miniaturized biological screening of various targets, their use for chemical synthesis is still limited. In this study, the influential palladium-catalyzed Suzuki–Miyaura reaction is successfully implemented at the nanoliter scale on droplet microarrays for the synthesis of an 800-compound library of biphenyls. Each reaction is carried out in individual 150 nL droplets. Remarkably, the synthesis of these 800 compounds requires a minimal amount of reagents, totaling 80 µmol, and a solvent volume of 400 µL. Furthermore, the cleavage kinetics and purity of the obtained biphenylic compounds are investigated. Via the solid-phase synthesis approach, the compounds could be purified from excess reactants and catalyst prior to the analysis and a UV-cleavable linker allows for fast and additive-free cleavage of each compound into the individual 100 nL droplet. This novel approach expands the toolbox of the droplet microarray for miniaturized high-throughput chemical synthesis and paves the way for future synthesis and screening of chemical compounds in a single platform
D. Lvdov. Ivlivs Fridericvs Hoepfner Ictvs Et Antecessor, H. A. Ordinis Ivridici Decanvs Dignissimorvm Candidatorvm Ioannis Isaaci Hofmanni Et Philippi Caroli Diehlii Moeno-Francofvrtensivm Solemnia Inavgvralia Indicit Ac Praetermissa Qvaedam De Basilicōn Libris Proponit
Giessen, Univ., Univ.-Schr., 1774Vorlageform des Erscheinungsvermerks: Gissae Ex Officina Bravniana MDCCLXXIV
Theoretisch-practischer Commentar über die Heineccischen Institutionen nach deren neuesten Ausgabe
von D. Ludwig Julius Friedrich HöpfnerVorlageform des Erscheinungsvermerks: Frankfurt am Mayn bey Varrentrapp Sohn und Wenner 1783
Warum sind die Menschenpflichten entweder vollkommene oder unvollkommene? und Welche Pflichten gehören zu der ersten welche zu der letzten Gattung?
Ein Programm von D. Ludwig Julius Friedrich Höpfner nebst einer Anzeige seiner WintervorlesungenVorlageform des Erscheinungsvermerks: Giesen gedruckt bey Johann Jacob Braun, Univ. Buchdr. 1779
Introdvctionis In Ivs Pvblicvm Romanorvm Antiqvvm Pavlo Plenioris Specimen : Programma Qvo Sollemnia Inavgvralia Candidatorvm Dignissimorvm Iacobi Abel, Et Io. Ioseph. Bened. Mariae Losskand, Wetzlariensivm Indicit D. Lvdovicvs Ivlivs Fridericvs Hoepfner, H. A. Ordinis Ivrisconsvltorvm Decanvs
Giessen, Univ., Univ.-Schr., 1781Vorlageform des Erscheinungsvermerks: Gissae Ex Officina Io. Iac. Bravn. MDCCLXXXI