Emittance Growth at LHC Injection from SPS and LHC Kicker Ripple

Fast pulsed kicker magnets are used to extract beams from the SPS and inject them into the LHC. The kickers exhibit time-varying structure in the pulse shape which translates into small offsets with respect to the closed orbit at LHC injection. The LHC damper systems will be used to damp out the resulting betatron oscillations, to keep the growth in the transverse emittance within specification. This paper describes the results of the measurements of the kicker ripple for the two systems, both in the laboratory and with beam, and presents the simulated performance of the transverse damper in terms of beam emittance growth. The implications for LHC operation are discussed

Tune Measurements in the SPS as a Multicycling Machine

Throughout the operation cycle of the SPS different particles are accelerated : High intensity protons, leptons and heavy ions. For each particle type a measurement of the betatron tunes along the acceleration cycle is required. The paper describes the different excitation and data analysis methods used in order to minimize beam blow-up during the measurements (protons) or in order to optimize the time resolution (leptons). Measurement examples are given

FEATURE RELEVANCE ANALYSIS FOR 3D POINT CLOUD CLASSIFICATION USING DEEP LEARNING

3D point clouds acquired by laser scanning and other techniques are difficult to interpret because of their irregular structure. To make sense of this data and to allow for the derivation of useful information, a segmentation of the points in groups, units, or classes fit for the specific use case is required. In this paper, we present a non-end-to-end deep learning classifier for 3D point clouds using multiple sets of input features and compare it with an implementation of the state-of-the-art deep learning framework PointNet++. We first start by extracting features derived from the local normal vector (normal vectors, eigenvalues, and eigenvectors) from the point cloud, and study the result of classification for different local search radii. We extract additional features related to spatial point distribution and use them together with the normal vector-based features. We find that the classification accuracy improves by up to 33% as we include normal vector features with multiple search radii and features related to spatial point distribution. Our method achieves a mean Intersection over Union (mIoU) of 94% outperforming PointNet++’s Multi Scale Grouping by up to 12%. The study presents the importance of multiple search radii for different point cloud features for classification in an urban 3D point cloud scene acquired by terrestrial laser scanning

Automated Classification of Airborne Laser Scanning Point Clouds

Making sense of the physical world has always been at the core of mapping. Up until recently, this has always dependent on using the human eye. Using airborne lasers, it has become possible to quickly "see" more of the world in many more dimensions. The resulting enormous point clouds serve as data sources for applications far beyond the original mapping purposes ranging from flooding protection and forestry to threat mitigation. In order to process these large quantities of data, novel methods are required. In this contribution, we develop models to automatically classify ground cover and soil types. Using the logic of machine learning, we critically review the advantages of supervised and unsupervised methods. Focusing on decision trees, we improve accuracy by including beam vector components and using a genetic algorithm. We find that our approach delivers consistently high quality classifications, surpassing classical methods

Progress with the Upgrade of the SPS for the HL-LHC Era

The demanding beam performance requirements of the High Luminosity (HL-) LHC project translate into a set of requirements and upgrade paths for the LHC injector complex. In this paper the performance requirements for the SPS and the known limitations are reviewed in the light of the 2012 operational experience. The various SPS upgrades in progress and still under consideration are described, in addition to the machine studies and simulations performed in 2012. The expected machine performance reach is estimated on the basis of the present knowledge, and the remaining decisions that still need to be made concerning upgrade options are detailed.Comment: 3 p. Presented at 4th International Particle Accelerator Conference (IPAC 2013

N-Methylimidazole Promotes The Reaction Of Homophthalic Anhydride With Imines

The addition of N-methylimidazole (NMI) to the reaction of homophthalic anhydride with imines such as pyridine-3-carboxaldehyde-N-trifluoroethylimine (9) reduces the amount of elimination byproduct and improves the yield of the formal cycloadduct, tetrahydroisoquinolonic carboxylate 10. Carboxanilides of such compounds are of interest as potential antimalarial agents. A mechanism that rationalizes the role of NMI is proposed, and a gram-scale procedure for the synthesis and resolution of 10 is also described

First Beam Commissioning of the 400 MHz LHC RF System

Hardware commissioning of the LHC RF system was successfully completed in time for first beams in LHC in September 2008. All cavities ware conditioned to nominal field, power systems tested and all Low level synchronization systems, cavity controllers and beam control electronics were tested and calibrated. Beam was successfully captured in ring 2, cavities phased, and a number of initial measurements made. These results are presented and tests and preparation for colliding beams in 2009 are outlined

Electron Cloud Effects in the CERN SPS and LHC

Electron cloud effects have been recently observed in the CERN SPS in the presence of LHC type proton beams with 25 ns bunch spacing. Above a threshold intensity of about 4 X 10^12 protons in 81 consecutive bunches, corresponding to half of the nomina

Microevolution of Pandemic Vibrio parahaemolyticus Assessed by the Number of Repeat Units in Short Sequence Tandem Repeat Regions

The emergence of the pandemic strain Vibrio parahaemolyticus O3:K6 in 1996 caused a large increase of diarrhea outbreaks related to seafood consumption in Southeast Asia, and later worldwide. Isolates of this strain constitutes a clonal complex, and their effectual differentiation is possible by comparison of their variable number tandem repeats (VNTRs). The differentiation of the isolates by the differences in VNTRs will allow inferring the population dynamics and microevolution of this strain but this requires knowing the rate and mechanism of VNTRs' variation. Our study of mutants obtained after serial cultivation of clones showed that mutation rates of the six VNTRs examined are on the order of 10−4 mutant per generation and that difference increases by stepwise addition of single mutations. The single stepwise mutation (SSM) was deduced because mutants with 1, 2, 3, or more repeat unit deletions or insertions follow a geometric distribution. Plausible phylogenetic trees are obtained when, according to SSM, the genetic distance between clusters with different number of repeats is assessed by the absolute differences in repeats. Using this approach, mutants originated from different isolates of pandemic V. parahaemolyticus after serial cultivation are clustered with their parental isolates. Additionally, isolates of pandemic V. parahaemolyticus from Southeast Asia, Tokyo, and northern and southern Chile are clustered according their geographical origin. The deepest split in these four populations is observed between the Tokyo and southern Chile populations. We conclude that proper phylogenetic relations and successful tracing of pandemic V. parahaemolyticus requires measuring the differences between isolates by the absolute number of repeats in the VNTRs considered

A Natural Love of Natural Products

Recent research on the chemistry of natural products from the author’s group that led to the receipt of the ACS Ernest Guenther Award in the Chemistry of Natural Products is reviewed. REDOR NMR and synthetic studies established the T-taxol conformation as the bioactive tubulin-binding conformation, and these results were confirmed by the synthesis of compounds which clearly owed their activity or lack of activity to whether or not they could adopt the T-taxol conformation. Similar studies with the epothilones suggest that the current tubulin-binding model needs to be modified. Examples of natural products discovery and biodiversity conservation in Suriname and Madagascar are also presented, and it is concluded that natural products chemistry will continue to make significant contributions to drug discovery. My first real exposure to natural products chemistry came in my third and final year as an undergraduate at Cambridge University, when I attended a course of lectures on the chemistry of natural products by the Nobel Prize-winning chemist Sir Alexander Todd (later to become Lord Todd). The lectures included many references to his own work in the field, with stories of his early work on the structure of cholesterol, th