443 research outputs found
Seismotectonics of the active thrust front in southwestern Sicily: hints on the Belice and Selinunte seismogenic sources
We present a seismotectonic model of the active thrust front in western Sicily, which includes the area hit by the
1968 Belice earthquake sequence. The ~40 km long South-WEstern Sicilian Thrust (SWEST) is formed by two aligned
albeit non-parallel fault arrays, the Granitola-Castelevetrano Thrust System (GCTS) in the west and the Partanna-
Poggioreale Thrust System (PPTS) in the east.
The ~NE-SW trending, NW-dipping GCTS straddles from the Pelagian coastline to Castelvetrano, is ~18 km long
and composed of two segments, with the northern, ~12 km long one showing geodetic and geologic evidence of active
deformation (Barreca et al., 2014). The segment is marked by a sharp gradient in Differential SAR interferometry
(DinSAR and STAMPs) and GPS velocity fields. Geologic evidence include an up to 60 m high, and up to 15° steep
scarp, which is the fore-limb of a broad fold involving Lower Pleistocene shore calcarenites, and cm-scale reverse
displacement of an ancient road dated as early Bronze-Hellenistic age. Inversion of fault slip-lineation data from
structures displacing the archaeological remains yields a ~N110°E shortening axis, consistent with the geodetic
shortening direction estimated from GPS differential velocities.
The ~ENE-WSW trending PPTS stretches from Partanna to the macro-seismic area of the 1968 earthquake sequence
and is composed of two ~10 km long segments limited by relay ramps. Although geologic and geodetic evidence of
deformation are less clear than for the GCTS, we nonetheless observe a gradient in interferometry data for the western
segment, and evidence of slow deformation (creep?) in historical to recent (last ~400 yr?) man-made structures.
Integration of geologic, geodetic and seismology data suggests the active folds and thrusts are the uppermost
expression of steep (45°) crustal ramps (Monaco et al., 1996) which upthrust the Saccense platform at depth.
Based on macroseismic and seismological evidence (Monaco et al., 1996), we contend that the PPTS was partly
activated during the 1968 sequence, and that rupture stopped at the junction with the GCTS. The current geodetic strain
accumulation on the GCTS, on the other hand, suggests that the fault array has been significantly loaded, and that its
last important co-seismic event could have been caused the 4th–5th century A.D. destruction of Selinunte (Bottari et al.,
2009)
Geodetic and geological evidence of active tectonics in south-westernSicily (Italy)
Integrated geological, geodetic and marine geophysical data provide evidence of active deformation insouth-western Sicily, in an area spatially coincident with the macroseismic zone of the destructive 1968Belice earthquake sequence. Even though the sequence represents the strongest seismic event recordedin Western Sicily in historical times, focal solutions provided by different authors are inconclusive onpossible faulting mechanism, which ranges from thrusting to transpression, and the seismogenic sourceis still undefined. Interferometric (DInSAR) observations reveal a differential ground motion on a SW–NEalignment between Campobello di Mazara and Castelvetrano (CCA), located just west of the maximummacroseismic sector. In addition, new GPS campaign-mode data acquired across the CCA alignment doc-uments NW–SE contractional strain accumulation. Morphostructural analysis allowed to associate thealignment detected through geodetic measurements with a topographic offset of Pleistocene marine sed-iments. The on-land data were complemented by new high-resolution marine geophysical surveys, whichindicate recent contraction on the offshore extension of the CCA alignment. The discovery of archaeo-logical remains displaced by a thrust fault associated with the alignment provided the first likely surfaceevidence of coseismic and/or aseismic deformation related to a seismogenic source in the area. Resultsof the integrated study supports the contention that oblique thrusting and folding in response to NW–SEoriented contraction is still active. Although we are not able to associate the CCA alignment to the 1968seismic sequence or to the historical earthquakes that destroyed the ancient Greek city of Selinunte,located on the nearby coastline, our result must be incorporated in the seismic hazard evaluation of thisdensely populated area of Sicily
A Web-Based Study of the Relationship of Duration of Insulin Pump Infusion Set Use and Fasting Blood Glucose Level in Adults with Type 1 Diabetes
Background: To evaluate the impact of infusion set use duration on glycemic control, we conducted an Internet-based study using the T1D Exchange's online patient community, Glu (myGlu.org). Subjects and Methods: For 14 days, 243 electronically consented adults with type 1 diabetes (T1D) entered online that day's fasting blood glucose (FBG) level, the prior day's total daily insulin (TDI) dose, and whether the infusion set was changed. Results: Mean duration of infusion set use was 3.0 days. Mean FBG level was higher with each successive day of infusion set use, increasing from 126?mg/dL on Day 1 to 133?mg/dL on Day 3 to 147?mg/dL on Day 5 (P<0.001). TDI dose did not vary with increased duration of infusion set use. Conclusions: Internet-based data collection was used to rapidly conduct the study at low cost. The results indicate that FBG levels increase with each additional day of insulin pump infusion set use.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/140356/1/dia.2014.0336.pd
Early hemispherectomy in catastrophic epilepsy A neuro-cognitive and epileptic long-term follow-up
SummaryThe authors report their experience about a neuro-cognitive and epileptic long-term follow-up of children with catastrophic epilepsy treated with hemispherectomy in the first 5 years of life.Nineteen children with resistant epilepsy that significantly interfered with their neuro-cognitive development underwent hemispherectomy within 5 years of life (mean: 2 years, 3 months; range: 5 months to 5 years). All patients were assessed before surgery and after, at least at the end of the follow-up (mean: 6 years and 6 months; range: 2–11 years and 2 months) with a full clinical examination including motor ability and functional status evaluation as well as behaviour observation, neuroimaging and an ictal/interictal prolonged scalp video-EEG.A seizure-free outcome was obtained in 73.7% of patients. Gross motility generally improved and cognitive competence did not worsen, with an evident progress in two cases.Consistently with previous reports, evolution was worse in cortical dysplasia than in progressive or acquired vascular cerebropathies. The excellent epileptic outcome and the lack of developmental deterioration in comparison with other more aged series seem to suggest a possible better evolution in earlier surgery treatment. To confirm this suggestion, however, further experience with larger series is needed
Home-based, early intervention with mechatronic toys for preterm infants at risk of neurodevelopmental disorders (CARETOY): a RCT protocol
Algebraic Comparison of Partial Lists in Bioinformatics
The outcome of a functional genomics pipeline is usually a partial list of
genomic features, ranked by their relevance in modelling biological phenotype
in terms of a classification or regression model. Due to resampling protocols
or just within a meta-analysis comparison, instead of one list it is often the
case that sets of alternative feature lists (possibly of different lengths) are
obtained. Here we introduce a method, based on the algebraic theory of
symmetric groups, for studying the variability between lists ("list stability")
in the case of lists of unequal length. We provide algorithms evaluating
stability for lists embedded in the full feature set or just limited to the
features occurring in the partial lists. The method is demonstrated first on
synthetic data in a gene filtering task and then for finding gene profiles on a
recent prostate cancer dataset
Co-circulation of SARS-CoV-2 Alpha and Gamma variants in Italy, February and March 2021
Background. Several SARS-CoV-2 variants of concern (VOC) have emerged through 2020 and 2021. There is need for tools to estimate the relative transmissibility of emerging variants of SARS-CoV-2 with respect to circulating strains.AimWe aimed to assess the prevalence of co-circulating VOC in Italy and estimate their relative transmissibility.Methods. We conducted two genomic surveillance surveys on 18 February and 18 March 2021 across the whole Italian territory covering 3,243 clinical samples and developed a mathematical model that describes the dynamics of co-circulating strains.Results. The Alpha variant was already dominant on 18 February in a majority of regions/autonomous provinces (national prevalence: 54%) and almost completely replaced historical lineages by 18 March (dominant across Italy, national prevalence: 86%). We found a substantial proportion of the Gamma variant on 18 February, almost exclusively in central Italy (prevalence: 19%), which remained similar on 18 March. Nationally, the mean relative transmissibility of Alpha ranged at 1.55-1.57 times the level of historical lineages (95% CrI: 1.45-1.66). The relative transmissibility of Gamma varied according to the assumed degree of cross-protection from infection with other lineages and ranged from 1.12 (95% CrI: 1.03-1.23) with complete immune evasion to 1.39 (95% CrI: 1.26-1.56) for complete cross-protection.Conclusion. We assessed the relative advantage of competing viral strains, using a mathematical model assuming different degrees of cross-protection. We found substantial co-circulation of Alpha and Gamma in Italy. Gamma was not able to outcompete Alpha, probably because of its lower transmissibility
A Combined Study on the Use of the Child Behavior Checklist 1½–5 for Identifying Autism Spectrum Disorders at 18 Months
The capacity of the Child Behavior Checklist 1½–5 (CBCL 1½–5) to identify children with autism spectrum disorder (ASD) at 18 months was tested on 37 children clinically referred for ASD and 46 children at elevated likelihood of developing ASD due to having an affected brother/sister. At 30 months the clinically referred children all received a confirmatory diagnosis, and 10 out of 46 siblings received a diagnosis of ASD. CBCL 1½-5 profiles were compared with a group of matched children with typical development (effect of cognitive level controlled for). The capacity of the CBCL 1½-5 DSM Oriented-Pervasive Developmental Problems scale to differentiate correctly between children diagnosed with ASD and children with typical development appeared dependent on group ascertainment methodology
Geology of the Victoria quadrangle (H02), Mercury
Mercury’s quadrangle H02 ‘Victoria’ is located in the planet’s northern hemisphere and lies between latitudes 22.5° N and 65° N, and between longitudes 270° E and 360° E. This quadrangle covers 6.5% of the planet’s surface with a total area of almost 5 million km2. Our 1:3,000,000-scale geologic map of the quadrangle was produced by photo-interpretation of remotely sensed orbital images captured by the MESSENGER spacecraft. Geologic contacts were drawn between 1:300,000 and 1:600,000 mapping scale and constitute the boundaries of intercrater, intermediate and smooth plains units; in addition, three morpho-stratigraphic classes of craters larger than 20 km were mapped. The geologic map reveals that this area is dominated by Intercrater Plains encompassing some almost-coeval, probably younger, Intermediate Plains patches and interrupted to the north-west, north-east and east by the Calorian Northern Smooth Plains. This map represents the first complete geologic survey of the Victoria quadrangle at this scale, and an improvement of the existing 1:5,000,000 Mariner 10-based map, which covers only 36% of the quadrangle
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