Extended Freeze-Dried BCG Instructed pDCs Induce Suppressive Tregs and Dampen EAE

Several clinical observations have shown that Bacillus Calmette-Guérin (BCG) vaccine has beneficial impact on patients suffering from different chronic inflammatory diseases. Here we evaluated whether BCG inactivated by Extended Freeze-Drying (EFD) which circumvents all the side effects linked to the live bacteria, could influence the development of experimental autoimmune encephalomyelitis (EAE), a mouse model for Multiple Sclerosis. EFD BCG strongly attenuates inflammation, both systemically and at the central nervous system (CNS) level, alleviating EAE. Mechanistically, EFD BCG directly impacts the phenotype of plasmacytoid dendritic cells (pDCs), and promotes their ability to induce suppressive IL-10 secreting regulatory T cells (Tregs) that inhibit encephalitogenic CD4+ T cells. When co-cultured with human allogenic naive CD4+ T cells, EFD BCG exposed human pDCs similarly induce the differentiation of IL-10 producing Tregs. Our study provides evidence that EFD BCG could be used as an immunomodulator of encephalitogenic T cells in multiple sclerosis patients

EULAR recommendations for the non-pharmacological management of systemic lupus erythematosus and systemic sclerosis

Objective To develop evidence-based recommendations for the non-pharmacological management of systemic lupus erythematosus (SLE) and systemic sclerosis (SSc). Methods A task force comprising 7 rheumatologists, 15 other healthcare professionals and 3 patients was established. Following a systematic literature review performed to inform the recommendations, statements were formulated, discussed during online meetings and graded based on risk of bias assessment, level of evidence (LoE) and strength of recommendation (SoR; scale AD , A comprising consistent LoE 1 studies, D comprising LoE 4 or inconsistent studies), following the European Alliance of Associations for Rheumatology standard operating procedure. Level of agreement (LoA; scale 0-10, 0 denoting complete disagreement, 10 denoting complete agreement) was determined for each statement through online voting. Results Four overarching principles and 12 recommendations were developed. These concerned common and disease-specific aspects of non-pharmacological management. SoR ranged from A to D. The mean LoA with the overarching principles and recommendations ranged from 8.4 to 9.7. Briefly, non-pharmacological management of SLE and SSc should be tailored, person-centred and participatory. It is not intended to preclude but rather complement pharmacotherapy. Patients should be offered education and support for physical exercise, smoking cessation and avoidance of cold exposure. Photoprotection and psychosocial interventions are important for SLE patients, while mouth and hand exercises are important in SSc. Conclusions The recommendations will guide healthcare professionals and patients towards a holistic and personalised management of SLE and SSc. Research and educational agendas were developed to address needs towards a higher evidence level, enhancement of clinician-patient communication and improved outcomes

Notes d'étymologie

Guyonvarc'h C. Notes d'étymologie. In: Annales de Bretagne. Tome 79, numéro 4, 1972. pp. 845-886

La mort de Muirchertach, fils d'Erc. Texte irlandais du très haut Moyen Âge : la femme, le saint et le roi

The Death of Muirchertach mac Erca The archaic account of the death of Muirchertach mac Erca is one of the most eloquent testimonies in Irish mythology and pseudo-history to the ambiguous and obscure relationship between declining paganism and triumphant Christianity. Composed in keeping with the oldest techniques of Celtic oral narrative — explanatory sections in prose alternating with long passages in verse that constitute the heart of the story — this text, following a very long process of transmission by manuscript, presents three symbolic characters : the saint, who embodies all the intransigence of Celtic Christianity ; the king of Tara, senile and worn out by the exercise of power, who suffers a triple sacrifical death : he is killed by his enemies, burned alive in afire in his palace and drowned in a vat of wine or beer; the woman of the afterworld, transformed into a creature of temptation and sin. The plot is evangelical in its simplicity: the woman uses magic to tempt the king, who succumbs and meets a tragic death; the saint, not without difficulty, is ultimately victorious and, as a sign of his total triumph, sends everyone to Paradise.Guyonvarc'h Christian-J. La mort de Muirchertach, fils d'Erc. Texte irlandais du très haut Moyen Âge : la femme, le saint et le roi. In: Annales. Économies, Sociétés, Civilisations. 38ᵉ année, N. 5, 1983. pp. 985-1015

Thomas Kinsella, éd., Yolande de Pontfarcy, introd. et Jean-Philippe Imbert, trad. — La Razzia, d'après l'épopée irlandaise Táin Bó Cúailnge. Neuvy-le-Roi, Alfil, 1996.

Guyonvarc'h Christian-J. Thomas Kinsella, éd., Yolande de Pontfarcy, introd. et Jean-Philippe Imbert, trad. — La Razzia, d'après l'épopée irlandaise Táin Bó Cúailnge. Neuvy-le-Roi, Alfil, 1996.. In: Cahiers de civilisation médiévale, 41e année, supplément annuel 1998. Comptes Rendus. pp. 50-51

Sociology of redundancy within "high performant" companies : normalisation of redundancy management and the destabilization of working patterns among executives

Cette recherche étudie la place du licenciement dans les trajectoires professionnelles, en confrontant les pratiques de réductions d’effectifs et les réactions de salariés cadres et techniciens licenciés. La thèse défend l’idée d’une banalisation du licenciement dans la gestion de l’emploi, qui prend la forme d’une atténuation de la logique de rupture que constitue le licenciement. L’extension du risque du licenciement et l’atténuation dont il fait l’objet n’ont pas banalisé pour autant l’épreuve pour les salariés. Le licenciement bouleverse les identités professionnelles, même pour des catégories jusque-là relativement épargnées. Quand cette acceptation du licenciement peut donner lieu à des recompositions identitaires, elles sont plus le signe d’une réponse imposée qu’une reconfiguration d’un nouveau rapport au travail. Tandis que les arrangements face à la mobilité sont isolés et ne reposent pas sur un socle collectif, l’épreuve du licenciement est individuelle et collective.This research studies the place of redundancy in careers, by confronting the practices of downsizing and the reactions of executives and technicians who have been made redundant. The thesis defends the idea of a “normalisation” of redundancy in the management of employment. The softening of the break due to the redundancy is at the core of this normalisation process led by managers. But such evolutions on the management’s side and the increase of the risk of redundancy do not minimize at all this experience for employees. Redundancy still destabilizes professional identities, even for categories of workers who have been relatively unaffected up to now. When the acceptance of redundancy leads to a new adaptation from employees, this indicates more a necessary reaction than a reconfiguration of a new relationship to the work. Adaptations of employees always remain individual. No clue of collective adaptations has been identified. However the test of redundancy is experienced both individually and collectively, as it destabilizes the working collective in companies

Thomas Kinsella, éd., Yolande de Pontfarcy, introd. et Jean-Philippe Imbert, trad. — La Razzia, d'après l'épopée irlandaise Táin Bó Cúailnge. Neuvy-le-Roi, Alfil, 1996.

Guyonvarc'h Christian-J. Thomas Kinsella, éd., Yolande de Pontfarcy, introd. et Jean-Philippe Imbert, trad. — La Razzia, d'après l'épopée irlandaise Táin Bó Cúailnge. Neuvy-le-Roi, Alfil, 1996.. In: Cahiers de civilisation médiévale, 41e année, supplément annuel 1998. Comptes Rendus. pp. 50-51

Benoit (Fernand), Le symbolisme dans les sanctuaires de la Gaule

le Roux-Guyonvarc'h Françoise. Benoit (Fernand), Le symbolisme dans les sanctuaires de la Gaule. In: Revue belge de philologie et d'histoire, tome 48, fasc. 3, 1970. Langues et littératures modernes - Moderne taal- en letterkunde. pp. 883-886

Myth and Law among the Indo-European, Studies of Indo-European Comparative Mythology

le Roux-Guyonvarc'h Françoise. Myth and Law among the Indo-European, Studies of Indo-European Comparative Mythology. In: Revue belge de philologie et d'histoire, tome 52, fasc. 3, 1974. Langues et littératures modernes - Moderne taal- en letterkunde. p. 728

Bayet (Jean). Croyances et rites dans la Rome antique

le Roux-Guyonvarc'h Françoise. Bayet (Jean). Croyances et rites dans la Rome antique. In: Revue belge de philologie et d'histoire, tome 52, fasc. 3, 1974. Langues et littératures modernes - Moderne taal- en letterkunde. pp. 766-767