715 research outputs found

    Mapping the Sensitive Volume of an Ion-Counting Nanodosimeter

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    We present two methods of independently mapping the dimensions of the sensitive volume in an ion-counting nanodosimeter. The first method is based on a calculational approach simulating the extraction of ions from the sensitive volume, and the second method on probing the sensitive volume with 250 MeV protons. Sensitive-volume maps obtained with both methods are compared and systematic errors inherent in both methods are quantified.Comment: 27 pages, 8 figures. Submitted to JINST, Jan. 16 200

    Specific glial populations regulate hippocampal morphogenesis

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    The hippocampus plays an integral role in spatial navigation, learning and memory, and is a major site for adult neurogenesis. Critical to these functions is the proper organization of the hippocampus during development. Radial glia are known to regulate hippocampal formation, but their precise function in this process is yet to be defined. We find that in Nuclear Factor I b (Nfib)-deficient mice, a subpopulation of glia from the ammonic neuroepithelium of the hippocampus fail to develop. This results in severe morphological defects, including a failure of the hippocampal fissure, and subsequently the dentate gyrus, to form. As in wild-type mice, immature nestin-positive glia, which encompass all types of radial glia, populate the hippocampus in Nfib-deficient mice at embryonic day 15. However, these fail to mature into GLAST- and GFAP-positive glia, and the supragranular glial bundle is absent. In contrast, the fimbrial glial bundle forms, but alone is insufficient for proper hippocampal morphogenesis. Dentate granule neurons are present in the mutant hippocampus but their migration is aberrant, likely resulting from the lack of the complete radial glial scaffold usually provided by both glial bundles. These data demonstrate a role for Nfib in hippocampal fissure and dentate gyrus formation, and that distinct glial bundles are critical for correct hippocampal morphogenesis

    A One-sided, Highly Relativistic Jet from Cygnus X-3

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    Very Long Baseline Array images of the X-ray binary, Cygnus X-3, were obtained 2, 4 and 7 days after the peak of a 10 Jy flare on 4 February 1997. The first two images show a curved one-sided jet, the third a scatter-broadened disc, presumably at the position of the core. The jet curvature changes from the first to the second epoch, which strongly suggests a precessing jet. The ratio of the flux density in the approaching to that in the (undetected) receding jet is > 330; if this asymmetry is due to Doppler boosting, the implied jet speed is > 0.81c. Precessing jet model fits, together with the assumptions that the jet is intrinsically symmetric and was ejected during or after the major flare, yield the following constraints: the jet inclination to the line of sight must be < 14 degrees; the cone opening angle must be < 12 degrees; and the precession period must be > 60 days.Comment: 12 pages 7 figures, accepted by Ap

    Whole Genome Sequence Analysis of Salmonella Typhi Isolated in Thailand before and after the Introduction of a National Immunization Program.

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    Vaccines against Salmonella Typhi, the causative agent of typhoid fever, are commonly used by travellers, however, there are few examples of national immunization programs in endemic areas. There is therefore a paucity of data on the impact of typhoid immunization programs on localised populations of S. Typhi. Here we have used whole genome sequencing (WGS) to characterise 44 historical bacterial isolates collected before and after a national typhoid immunization program that was implemented in Thailand in 1977 in response to a large outbreak; the program was highly effective in reducing typhoid case numbers. Thai isolates were highly diverse, including 10 distinct phylogenetic lineages or genotypes. Novel prophage and plasmids were also detected, including examples that were previously only reported in Shigella sonnei and Escherichia coli. The majority of S. Typhi genotypes observed prior to the immunization program were not observed following it. Post-vaccine era isolates were more closely related to S. Typhi isolated from neighbouring countries than to earlier Thai isolates, providing no evidence for the local persistence of endemic S. Typhi following the national immunization program. Rather, later cases of typhoid appeared to be caused by the occasional importation of common genotypes from neighbouring Vietnam, Laos, and Cambodia. These data show the value of WGS in understanding the impacts of vaccination on pathogen populations and provide support for the proposal that large-scale typhoid immunization programs in endemic areas could result in lasting local disease elimination, although larger prospective studies are needed to test this directly

    Probing the Cosmic Distance Duality Relation with the Sunyaev-Zeldovich Effect, X-rays Observations and Supernovae Ia

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    The angular diameter distances toward galaxy clusters can be determined with measurements of the Sunyaev-Zel'dovich effect and X-ray surface brightness combined with the validity of the distance-duality relation, DL(z)(1+z)2/DA(z)=1D_L(z) (1 + z)^{2}/D_{A}(z) = 1, where DL(z)D_L(z) and DA(z)D_A(z) are, respectively, the luminosity and angular diameter distances. This combination enables us to probe galaxy cluster physics or even to test the validity of the distance-duality relation itself. We explore these possibilities based on two different, but complementary approaches. Firstly, in order to constrain the possible galaxy cluster morphologies, the validity of the distance-duality relation (DD relation) is assumed in the Λ\LambdaCDM framework (WMAP7). Secondly, by adopting a cosmological-model-independent test, we directly confront the angular diameters from galaxy clusters with two supernovae Ia (SNe Ia) subsamples (carefully chosen to coincide with the cluster positions). The influence of the different SNe Ia light-curve fitters in the previous analysis are also discussed. We assumed that η\eta is a function of the redshift parametrized by two different relations: η(z)=1+η0z\eta(z) = 1 + \eta_{0}z, and η(z)=1+η0z/(1+z)\eta(z)=1 + \eta_{0}z/(1+z), where η0\eta_0 is a constant parameter quantifying the possible departure from the strict validity of the DD relation. The statistical analysis presented here provides new evidence that the true geometry of clusters is elliptical. We find that the two-light curve fitters (SALT2 and MLCS2K2) present a statistically significant conflict, and a joint analysis involving the different approaches suggests that clusters are endowed with an elliptical geometry as previously assumed.Comment: 33 pages, 15 figures, some typos corrected, accepted for publication in the Astronomy \& Astrophysic

    Climate change adaptation in agriculture: Ex ante analysis of promising and alternative crop technologies using DSSAT and IMPACT

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    Achieving and maintaining global food security is challenged by changes in population, income, and climate, among other drivers. Assessing these challenges and possible solutions over the coming decades requires a rigorous multidisciplinary approach. To answer this challenge, the International Food Policy Research Institute (IFPRI) has developed a system of linked simulation models of global agriculture to do long-run scenario analysis of the effects of climate change and various adaptation strategies. This system includes the core International Model for Policy Analysis of Agricultural Commodities and Trade (IMPACT), which is linked to water models (global hydrology, water basin management, and water stress on crops) and crop simulation models. The Global Futures and Strategic Foresight program, a CGIAR initiative led by IFPRI in collaboration with other CGIAR research centers, is working to improve these tools and conducting ex ante assessments of promising technologies, investments, and policies under alternative global futures. Baseline projections from IMPACT set the foundation with the latest outlook on long-term trends in food demand and agricultural production based on projected changes in population, income, technology, and climate. On top of the baseline, scenarios are developed for assessing the impacts of promising climate-adapted technologies for maize, wheat, rice, potatoes, sorghum, groundnut, and cassava on yields, area, production, trade, and prices in 2050 at a variety of scales. Yield gains from adoption of the selected technologies vary by technology and region, but are found to be generally comparable in scale to (and thus able to offset) the adverse effects of climate change under a high-emissions representative concentration pathway (RCP 8.5). Even more important in this long-term climate change scenario are effects of growth in population, income, and investments in overall technological change, highlighting the importance of linked assessment of biophysical and socioeconomic drivers to better understand climate impacts and responses. For all crops in the selected countries, climate change impacts are negative with the baseline technology. All new technologies have beneficial effects on yields under climate change, with combined traits (drought and heat tolerance) showing the greatest benefi
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