Group Conditions for Entrepreneurial Visions: Role Confidence, Hierarchical Congruences, and the Imagining of Future in Entrepreneurial Groups

An essential part of entrepreneurial activity is the drafting and narrating of an entrepreneurial vision. This study is premised on the observation that entrepreneurial groups form an interaction arena for the practice of imagining the future and asks how the content of entrepreneurial visions is shaped by the conditions of the group. Taking an entrepreneurship-as-practice lens, which we enrich with sociological theory on the future (Beckert) and small groups (Fine), we engage in an in-depth case study of 12 entrepreneurial groups. We show how the content of entrepreneurial visions is configured by four elements (i.e., fictional expectation for the business or the group; future orientation that is continuing or divergent) and name two group conditions (i.e., role confidence and hierarchical congruence) that direct their configuration. We propose that lacking role confidence can impede thinking about the future of a business and that narrative hierarchies that challenge structural hierarchies can open a window for divergent future orientation. This study contributes to a novel theoretical understanding of where entrepreneurial visions come from by emphasizing politics of expectations within groups and calling to consider group conditions as a relevant context for entrepreneurial visions

Two Cases of Cerebral Sinus Venous Thrombosis Following Chemotherapy for Non-Seminomatous Germ Cell Tumor

We report on two patients with cerebral sinus venous thrombosis following chemotherapy with cisplatin, bleomycin and etoposide for non-seminomatous germ cell tumor. Headache and neurological deficits were the leading symptoms. Cancer and cisplatin chemotherapy are well-known risk factors for thromboembolic events. The therapeutic strategy is an anticoagulant therapy. Symptoms are usually reversible within weeks under this therapy. Therefore, in patients with testicular cancer and chemotherapy who present with neurological symptoms, cerebral sinus venous thrombosis should be considered in the differential diagnosis

Remote brainstorming: Methodological interventions in designing from a distance

This paper examines the immediate effects of group methods in facilitating remote team collaboration. We recruited seven teams with prior experience working together. All teams completed two current, complex, and open-ended design challenges using remote tools. We examined design activities before and after teams were given a design method intervention. The interventions were a Brainstorming Method to promote divergent thinking and the Five-Whys method to promote analytical thinking. Using OpenFace, we observed changes in emotion by examining facial expressions. We found that the brainstorming intervention did not have a change in ideation performance and the problem analysis intervention had a decrease in ideation performance. Teams used digital media to facilitate communication but were constrained by the media\u27s tools. Our results can inform teams in organizations interested in promoting divergent thinking to not expect immediate improvements in ideation performance following the introduction of a design method. Future research is required to identify relevant abilities and social skills needed to facilitate remote ideation through design methods

Gartenstadt Hellerau - Kulturdenkmale im Porträt

Die Gartenstadt ist von herausragender bau-, sozial-, industrie- und kulturgeschichtlicher Bedeutung. Sie spiegelt die vielfältigen Ideale und Utopien der Lebensreform wider und bewirbt sich damit für das UNESCO-Welterbe. Hellerau gilt als Pionier eines nachhaltigen Städtebaus und als eine der bedeutendsten frühen Gartenstädte weltweit. In der Siedlungsgemeinschaft werden sowohl gesunde Wohn- und Arbeitsverhältnisse als auch ein kulturreiches und naturverbundenes Leben geboten. Sie ist geprägt von Architektur- und Städtebaudiskursen in England und Deutschland, insbesondere der Gartenstadt- sowie der Arts-and-Craft-Bewegung und dem Deutschen Werkbund, als dessen erste informelle Siedlung Hellerau gilt. Insbesondere die Wohnbebauung ist für die Entwicklung der modernen Architektur und des modernen Städtebaus bedeutsam. Typisierung, Standardisierung und seriell gefertigte Bauteile sind bahnbrechend für die Entwicklung eines kostengünstigen, funktionalen, gestalterisch hochwertigen und gemeinschaftsbildenden Wohnungs- und Siedlungsbaus. Redaktionsschluss: Dezember 202

Entanglement and Timing-Based Mechanisms in the Coherent Control of Scattering Processes

The coherent control of scattering processes is considered, with electron impact dissociation of H$_2^+$ used as an example. The physical mechanism underlying coherently controlled stationary state scattering is exposed by analyzing a control scenario that relies on previously established entanglement requirements between the scattering partners. Specifically, initial state entanglement assures that all collisions in the scattering volume yield the desirable scattering configuration. Scattering is controlled by preparing the particular internal state wave function that leads to the favored collisional configuration in the collision volume. This insight allows coherent control to be extended to the case of time-dependent scattering. Specifically, we identify reactive scattering scenarios using incident wave packets of translational motion where coherent control is operational and initial state entanglement is unnecessary. Both the stationary and time-dependent scenarios incorporate extended coherence features, making them physically distinct. From a theoretical point of view, this work represents a large step forward in the qualitative understanding of coherently controlled reactive scattering. From an experimental viewpoint, it offers an alternative to entanglement-based control schemes. However, both methods present significant challenges to existing experimental technologies

Would the Real Loneliness Please Stand Up? The Validity of Loneliness Scores and the Reliability of Single-Item Scores

Several measures that assess loneliness have been developed for adults. Across three studies, we investigated psychometric features of scores of different versions of the Rasch-Type Loneliness Scale, the University of California Los Angeles Loneliness Scale, and three single-item measures. In Study 1 (N = 697 self-ratings, N = 282 informant-ratings of 160 targets) and Study 2 (N = 1,216 individuals from 608 couples), we investigated convergent validity, self-informant agreement, and nomological nets of the item scores using correlates related to demographic aspects, personality, satisfaction, and network characteristics. In Study 3 (N = 411), we estimated a reliability of rxx > .70 for scores of three single-item measures of loneliness. Overall, scores of all measures and their nomological nets were highly correlated within and across studies, indicating that the scores of the included measures are all reliable and valid. Recommendations for choosing a loneliness measure are discussed

Smoking trends and health equity in Switzerland between 1992 and 2017: dependence of smoking prevalence on educational level and social determinants

BackgroundSwitzerland ranks among the top three healthcare systems in the world with regards to healthcare access, suggesting a high degree of health equity. However, Switzerland has few preventive strategies against smoking abuse. The aim of this study is to clarify whether educational level and citizenship status have an influence on the prevalence of smoking in Switzerland and whether there is health inequity related to a lack of preventive strategies.MethodsWe based our analysis on publicly available health data published in the Swiss government's Swiss health survey (1992–2017). We compared the prevalence of smoking across the years and correlated these data with levels of educational attainment, citizenship status and age.ResultsA continuous significant decline in smokers is observed in the highest education group (TERT). Over time, prevalence was reduced from 29% in 1992 to 23% in 2017 (p < 0.001). The intermediate-level educational group (SEK 2) showed smaller but also significant decline on a 0.05 sigificance level over the same period, from 31% to 29% (p = 0.003). The lowest educational group showed a nonsignificant decline from 28% to 27% (p = 0.6). The population who holds Swiss citizenship showed a decrease in smoking from 28% to 26% within the time frame (p < 0.001). People without Swiss citizenship had a much higher prevalence of smokers, at 38% in 1992 and declining to 32% in 2017 (p < 0.001). All cohorts from age 15 to age 64 have a far higher prevalence of smokers than cohorts at an older age, with the highest prevalence in the 25–34 age group.ConclusionIn Switzerland, individuals with lower levels of education and non-Swiss populations are more susceptible to health risk of smoking. This is despite the existence of a high-quality healthcare system that has nevertheless failed to negated health inequities

Contrast-Enhanced CT Density Predicts Response to Sunitinib Therapy in Metastatic Renal Cell Carcinoma Patients.

The first-line therapy in metastatic renal cell carcinoma (mRCC), sunitinib, exhibits an objective response rate of approximately 30%. Therapeutic alternatives such as other tyrosine kinase inhibitors, VEGF inhibitors, or mTOR inhibitors emphasize the clinical need to predict the patient's response to sunitinib therapy before treatment initiation. In this study, we evaluated the prognostic value of pretreatment portal venous phase contrast-enhanced computed tomography (CECT) mean tumor density on overall survival (OS), progression-free survival (PFS), and tumor growth in 63 sunitinib-treated mRCC patients. Higher pretreatment CECT tumor density was associated with longer PFS and OS [hazard ratio (HR)=0.968, P=.002, and HR=0.956, P=.001, respectively], and CECT density was inversely correlated with tumor growth (P=.010). Receiver operating characteristic analysis identified two CECT density cut-off values (63.67 HU, sensitivity 0.704, specificity 0.694; and 68.67 HU, sensitivity 0.593, specificity 0.806) which yielded subpopulations with significantly different PFS and OS (P<.001). Pretreatment CECT is therefore a promising noninvasive strategy for response prediction in sunitinib-treated mRCC patients, identifying patients who will derive maximum therapeutic benefit

Mechanism and specificity of pentachloropseudilin-mediated inhibition of myosin motor activity.

Here, we report that the natural compound pentachloropseudilin (PClP) acts as a reversible and allosteric inhibitor of myosin ATPase and motor activity. IC(50) values are in the range from 1 to 5 μm for mammalian class-1 myosins and greater than 90 μm for class-2 and class-5 myosins, and no inhibition was observed with class-6 and class-7 myosins. We show that in mammalian cells, PClP selectively inhibits myosin-1c function. To elucidate the structural basis for PClP-induced allosteric coupling and isoform-specific differences in the inhibitory potency of the compound, we used a multifaceted approach combining direct functional, crystallographic, and in silico modeling studies. Our results indicate that allosteric inhibition by PClP is mediated by the combined effects of global changes in protein dynamics and direct communication between the catalytic and allosteric sites via a cascade of small conformational changes along a conserved communication pathway

Quantum inference of states and processes

The maximum-likelihood principle unifies inference of quantum states and processes from experimental noisy data. Particularly, a generic quantum process may be estimated simultaneously with unknown quantum probe states provided that measurements on probe and transformed probe states are available. Drawbacks of various approximate treatments are considered.Comment: 7 pages, 4 figure